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Douglas Moellering, Ph.D.

Douglas R. Moellering, PhD
 
Assistant Professor
G004 Volker Hall
1670 University Blvd.
Birmingham, AL 35294
Phone: (205) 996-2660 or (205) 996-5895
dmoellering@uab.edu
Website


Dr. Moellering is an instructor of nutrition sciences, a scientist in the Center for Cardiovascular Biology, a scientist in the UAB Comprehensive Diabetes Center (UCDC), and manager of the Diabetes Research and Training Center's Redox Biology Core (BARB) at UAB. Dr. Moellering developed and manages the Redox Core serving multiple investigators in measuring functional mitochondrial physiology, bioenergentics, enzyme activity, markers of oxidative stress, and reactive oxygen species formation.

Education

Thomas More College, Crestview Hills, KY
BA, Biology, 1991

University of Alabama at Birmingham
MS, Basic Medical Sciences (Physiology & Biophysics), 1995

University of Alabama at Birmingham
PhD, Cellular and Molecular Pathology, 2003

Post-Graduate Training

University of Alabama at Birmingham
Postdoctoral Fellow, Department of Nutrition Sciences, 2003-8

Research Interest

Eighty percent of the air we breathe and most of the food that is consumed and absorbed are metabolized within mitochondria to produce 90 percent of the energy in the form of ATP necessary for use in all cellular processes, including exercise, growth, and reproduction. Evidence has been accumulating that many diseases involve mitochondrial dysfunction with concomitant increased reactive oxygen and/or nitrogen species formation. Some of these diseases include insulin resistance, type 2 diabetes mellitus (T2DM), Parkinson's disease, Alzheimer's disease, cardiovascular disease, atherosclerosis, cancer, obesity, and Harman’s free-radical theory of aging (although aging is not a disease). These reactive products are called free radicals since they contain one or more unpaired electrons. Free radical-mediated alterations in energy production, tissue injury, and human disease are pervasive, and still poorly understood. Our research interests involve mitochondrial physiology, bioenergetics, and free radical-mediated tissue injury and disease pathologies. Currently our research is focused on mitochondrial free-radical production contributing to altered bioenergetics, the development of obesity, insulin resistance and T2DM, increased cardiovascular disease susceptibility, and aging.