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Emily Dhurandhar, Ph.D.

Emily Dhurandhar, Ph.D.
 
Nutrition Obesity Research Center
LHL 409
University of Alabama at Birmingham
Birmingham, AL 35294
Phone: (205) 934-6032
Fax: (205) 934-9325
E-mail: edhurand@uab.edu
Full CV


I am currently a postdoctoral trainee in the Obesity Training Program (DK062710) at University of Alabama at Birmingham. My doctoral work focused on adipogenic human adenovirus type 36, and how it alters fat and glucose metabolism to explain its paradoxical association with both body fatness and improved glycemic control in humans. This work fostered my interest in further elucidating the contribution of exogenous environmental factors that alter whole-body metabolism to result in obesity. I am particularly interested in factors that disrupt compensation mechanisms for perturbations in energy balance, that may explain interindividual variability in compensation. During my postdoctoral fellowship, I am obtaining training to study and quantify these effects in human populations. For example, with the aid of statistical genetics expertise in the program, I am working to quantify the extent to which assortative mating may contribute to propagation of obesityover generations. In addition, the core facilities and clinical trial expertise in the program have fostered the development of several clinical trials that examine compensation in free-living individuals. I will be testing the effectiveness of recommendations to eat or skip breakfast on changing body weight, since evidence suggests skipping breakfast may lead to inadequate compensation and lower energy intake throughout the day. I am also developing a project to test the impact of various nutrition education video game characteristics on subsequent energy intake in children. Lastly, I am working with a team to develop an algorithm to quantify active compensation that occurs in free-living individuals in response to energy perturbations using meta-analysis techniques.

Publications

  • 2012
  • 2011
  • 2009
  • 2008
  • 2007
  1. Krishnapuram R, Kirk-Ballard H, Dhurandhar EJ, Dubuisson O, Virginie Messier V, Rabasa-Lhoret R, Hegde V, Aggarwal S, Dhurandhar NV. Insulin Receptor-independent Up-regulation of Cellular Glucose Uptake. International Journal of Obesity. 2012 Feb 7. [doi: 10.1038/ijo.2012.6]
     
  2. Gohlke JM, Dhurandhar EJ, Correll CU, Morrato EH, Newcomer JW, Remington G, Nasrallah HA, Crystal S, Nicol G; Adipogenic and Metabolic Effects of APDs Conference Speakers, Allison DB. Recent Advances in Understanding and Mitigating Adipogenic and Metabolic Effects of Antipsychotic Drugs. Front Psychiatry. 2012;3:62. Epub 2012 Jun 28. [PMID: 22754543] [PMCID: PMC3385013]]
     
  3. Dhurandhar EJ, Krishnapuram R, Hegde V, Dubuisson O, Dong X, Ye J, Civitarese A, Dhurandhar NV. E4orf1 Improves Hepatic Lipid and Glucose Metabolism: A Potential Agent to Improve Steatosis and Hepatic Insulin Resistance. Under Review at PLoS ONE.
     
  4. Loop M, Wood AC, Thomas AS, Shikany JM, Dhurandhar EJ, Gadbury GL, Allison DB. Submitted for Your Consideration: PotentialAdvantages of a Novel Clinical Trial Design and Initial Patient Reaction. Under review at Frontiers in Pharmacogenetics and Pharmacogenomics.
     
  5. Dhurandhar EJ, Allison DB, van Groen T, Kadish I. Hunger in the Absence of Caloric Restriction Improves Cognition and Attenuates Alzheimer's Disease Pathology in a Mouse Model. Under review at Journal of Alzheimer's Disease.
  1. Krishnapuram R, Dhurandhar EJ, Dubuisson O, Kirk-Ballard H, Bajpeyi S, Butte N, Sothern MS, Larsen-Meyer E, Chalew S, Bennett B, Gupta AK, Greenway FL, Johnson W, Brashear M, Reinhart G, Rankinen T, Bouchard C, Cefalu WT, Ye J, Javier R, Zuberi A, Dhurandhar NV. Template to improve glycemic control without reducing adiposity or dietary fat. Am J Physiol Endocrinol Metab. 2011 May;300(5):E779-89. Epub 2011 Jan 25. [PMID: 21266671]
     
  2. Emily J Dhurandhar, Olga Dubuisson, Nazar Mashtalir, Rashmi Krishnapuram, Vijay Hedge, and Nikhil V. Dhurandhar. E4orf1: A Novel Ligand that Improves Glucose Disposal in Cell Culture. Accepted for publication in PLoS ONE.
     
  3. Dubuisson O, Dhurandhar EJ, Krishnapuram R, Kirk-Ballard H, Gupta AK, Hegde V, Floyd E, Gimble JM, Dhurandhar NV. PPARgamma-independent increase in glucose uptake and adiponectin abundance in fat cells. Endocrinology. 2011;152(10):3648-60. [PMID: 21791563]
     
  1. Rathod MA, Rogers PM, Vangipuram SD, Emily J. McAllister, and Dhurandhar NV. Adipogenic Cascade can be Induced without Adipogenic Media by a Human Adenovirus. Obesity 2009 Jan 22. [Epub ahead of print] [PMID: 19165154]
     
  2. Rathod MA, Rogers PM, Vangipuram SD, Emily J. McAllister, and Dhurandhar NV. Adipogenic Cascade can be Induced without Adipogenic Media by a Human Adenovirus. Obesity 2009 Jan 22. [Epub ahead of print] [PMID: 19165154]
     
  3. McAllister EJ, Dhurandhar NV, Keith SW, Aronne LJ, Barger J, Baskin M, Benca RM, Biggio J, Boggiano MM, Eisenmann JC, Elobeid M, Fontaine KR, Gluckman P, Hanlon EC, Katzmarzyk P, Pietrobelli A, Redden DT, Ruden DM, Wang C, Waterland RA, Wright SM, Allison DB. Ten putative contributors to the obesity epidemic. Crit Rev Food Sci Nutr. 2009 Nov;49(10):868-913. [PMID: 19960394]
  1. Rogers PM, Fusinski KA, Rathod MA, Loiler SA, Pasarica M , Shaw MK, Kilroy G, Sutton GM, McAllister EJ, Mashtalir N, Gimble JM, Holland TC, and Dhurandhar NV. Human adenovirus Ad-36 induces adipogenesis via its E4 orf-1 gene. International Journal of Obesity 2008; 32(3):397-406. [PMID: 17984979]
     
  2. Pasarica M, Mashtalir N, McAllister EJ, Kilroy GE, Koska J, Permana P, de Courten B, Yu M, Ravussin E, Gimble JM, Dhurandhar NV. Adipogenic Human Adenovirus Ad-36 Induces Commitment, Differentiation and Lipid Accumulation in Human Adipose-derived Stem Cells. Stem Cells. 2008; 26(4):969-78. [PMID: 18203674]
  1. Rice S, McAllister E and Dhurandhar NV. Fast food: Friendly ? International Journal of Obesity 2007 31(6):884-6. [PMID: 17342073]
     

 

Acknowledgement and Disclaimer
The trainee's projects are supported by Grant Number T32DK062710 from the National Institute of Diabetes and Digestive and Kidney Diseases. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Diabetes and Digestive and Kidney Diseases or the National Institutes of Health.

Years: 2011 - 2014
Mentor(s): David B. Allison, Ph.D.