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John C. Chatham, DPhil

John C. Chatham, DPhil
 
Professor
Dept. of Medicine
Division of Cardiovascular Disease
MCLM 684
Phone: 205-934-0240
jchatham@uab.edu
Website


John Charles Chatham was born in Didmarton, Gloucestershire, England in May 1960. He received a B.Sc. (Hons) degree in Chemistry from the University of Southampton England (1983) and a D.Phil. in Biochemistry from University of Oxford (1987). In 1987 he moved to the USA first to a postdoctoral fellowship at Huntington Medical Research Institutes, Pasadena, CA and then to Department of Radiology at Johns Hopkins University School of Medicine. After his postdoctoral training he joined the faculty at Johns Hopkins School of Medicine first as an Instructor and then as an Assistant Professor in the Department of Radiology. He earned the title of Associate Professor of Medicine after coming to UAB in 2000. In 2011 he was appointed as Professor and Director of the Division of Molecular and Cellular Pathology in the Department of Pathology at UAB and Co-Director of the UAB Comprehensive Cardiovascular Center. He served as Chair of the UAB Faculty senate 2011-2012 and was Chair of the Science Policy Committee for the American Physiology Society from 2010-2013. He is currently a member of the Science Policy committee for the Federation of American Societies for Experimental Biology and was recently elected to serve on Council for the American Physiology Society

Research/Clinical Interest

The overall goal of his laboratory is to understand the impact of alterations in cardiac energy metabolism and substrate utilization on the cardiomyocyte function. We have three major areas of interest: 1) Investigating the mechanisms leading to the increased incidence of heart failure in patients with diabetes and 2) development of new metabolically based therapeutic interventions for the treatment of ischemic heart disease 3) development of metabolic interventions to improve outcomes following trauma and hemorrhage. A common theme to all these projects is the role glucose in post-translational modifications of proteins mediated by the hexosamine biosynthesis pathway leading to protein-O-glycosylation. We propose that this is a central mechanism by which changes in metabolism are transduced into alterations in cellular function. Projects currently underway in our laboratory includes studies involving isolated cardiomyocytes, intact isolated perfused hearts and whole animal models. We use 13C and 1H nuclear magnetic resonance (NMR) spectroscopy to determine metabolic fluxes in the intact heart. In addition, we also use a range of standard physiological, biochemical and molecular techniques. We are also currently exploring proteomic and mass spectrometric methods for the identification and characterization of O-glycosylated proteins.

Education:

University of Southampton, England 
BSc, Chemistry, 1983

University of Oxford, England 
DPhil, Biochemistry, 1987

Post-Graduate Training:

Huntington Medical Research Institutes Pasadena, CA
Postdoctoral Fellow, 1987

Johns Hopkins University School of Medicine Baltimore, MD
Postdoctoral Fellow, 1987-9