School of Public Health
Department of Environmental Health Sciences
Ryals Bldg. 530B, 1665 University Blvd
Birmingham AL 35294
Phone: (205) 934-7060
The overall focus of my research is development of methods to assess the role of the environment in human health. I am currently pursuing two lines of research within this broad framework:
- Health implications of energy use and climate change: We are currently conducting community-based research to evaluate if there are differences in vulnerability to heatwaves in urban versus rural settings in Alabama. We are also conducting research on the Deepwater Horizon (DH) blowout, exploring ways to improve the risk assessment and communication tools used to determined seafood safety. We are examining the implications of the global expansion of oil exploration in deepwaters, and have communicated the lessons learned from the DH oil spill to interested parties in Ghana, as they develop environmental monitoring and oil spill response plans for their burgeoning oil industry: www.soph.uab.edu/ghanaoilseminar/.
- Development of alternative methods for evaluating developmental toxicity: Currently, we are exploring the utility of Daphnia as a whole animal, invertebrate model system for human health research. We are also working on computational approaches in neurodevelopmental risk assessment that incorporate molecular datasets describing mechanisms of brain development and impacts of toxicants.
- Smith, TT, BF Zaitchik, JM Gohlke. (2012). Heat waves in the United States: definitions, patterns and trends. Climatic Change DOI 10.1007/s10584-012-0659-2
- Gohlke JM, EJ Dhurandhar, CU Correll, EH Morrato, JW Newcomer, G Remington, HA Nasrallah, S Crystal, G Nicol, DB Allison. (2012). Recent advances in understanding and mitigating adipogenic and metabolic effects of antipsychotic drugs. Front Psychiatry 3: 62.
- Gohlke JM, D Doke, M Tipre, M Leader, T Fitzgerald. 2011. A review of seafood safety after the Deepwater Horizon blowout. Environ Health Perspect. Environ Health Perspect. 119(8): 1062-9 PMCID: PMC3237364
- Gohlke JM, Thomas R, Woodward A, Campbell-Lendrum D, Prüss-Ustün A, Hales S, Portier CJ. (2011). Estimating the Global Public Health Implications of Electricity and Coal Consumption. Environ Health Perspect. 119(6): 821-6. PMCID: PMC3114817
- Portier CJ, KT Tart, SR Carter, AE Grambsch, JM Gohlke, J Hess, SN Howard, G Luber, JT Lutz, T Maslak, N Prudent, M Radtke, JP Rosenthal, T Rowles, PA Sandifer, J Scheraga, PJ Schramm, D Strickman, JM Trtany, PY Whung. (2010). A Human Health Perspective on Climate Change: A report outlining research needs on the human health effects of climate change. Published by Environmental Health Perspectives and the National Institute of Environmental Health Sciences. www.niehs.nih.gov/climatereport.
- Gohlke JM, Stockton PS, Sieber S, Foley J, Portier CJ. (2009). AhR-mediated gene expression in the developing mouse telencephalon. Reproductive Toxicology 28(3):321-8.
- Gohlke J.M., R. Thomas, Y. Zhang, M.C. Rosenstein, A.P. Davis, C. Murphy, C.J. Mattingly, K.G. Becker, C.J. Portier (2009). The Genetic and Environmental Pathways to Complex Diseases. BMC Systems Biology 3: 46.
- Thomas R, J.M. Gohlke , F. Parham, C.J. Portier (2009). Choosing the right path: Enhancement of biologically-relevant sets of genes or proteins using pathway structure. Genome Biology 10(4):R44.
- Gohlke, J.M., O Armant, FM Parham, MV Smith, D Castro, L Nguyen, JS Parker, G Gradwohl, CJ Portier, F Guillemot. (2008). A Gene Regulatory Network for Telencephalon Development Combining Experimental and Bioinformatics Approaches. BMC Biology 6(1): 15.
- Gohlke, J.M., Griffith, W.C., and Faustman, E.M. (2008) Computational Models of Ethanol-induced Neurodevelopmental Toxicity Across Species: Implications for Risk Assessment. Birth Defects Research Part B: Developmental and Reproductive Toxicology 83(1): 1-11
- Gohlke, J.M., SH Hrynkow, CJ Portier (2008). Health, Economy, and Environment: Sustainable Energy Choices for a Nation. Environ Health Perspect 116 (6): A236-237.
- Gohlke, J.M., S. Hiller-Sturmhoefel, E. M. Faustman. (2008). A Systems-Based Computational Model of Alcohol’s Toxic Effects on Brain Development. Alcohol Research and Health 31(1): 76-83.
- Gohlke, J.M., CJ Portier (2007) The forest for the trees: A systems framework for risk assessment. Environ Health Perspect 115:1261–1263.
- Gohlke, J.M., Griffith, W.C. and Faustman, E.M. (2007). Computational Models of Neocortical Neuronogenesis and Programmed Cell Death in the Developing Mouse, Monkey and Human. Cerebral Cortex, 17: 2433-2442.
- Gohlke, J.M., Griffith, W.C., & Faustman, E.M. (2005). A systems-based computational model for dose-response comparisons of two mode of action hypotheses for ethanol-induced neurodevelopmental toxicity. Toxicological Sciences, 86(2), 470-484.
- Faustman, E. M., Gohlke, J., Judd, N. L., Lewandowski, T. A., Bartell, S. A., & Griffith, W. C. (2005). Modeling developmental processes in animals: applications in neurodevelopmental toxicology. Environmental Toxicology and Pharmacology, 19(3), 615-624.
- Gohlke, J.M., W. C. Griffith and E. M. Faustman (2004). The role of cell death during neocortical neurogenesis and synaptogenesis: Implications from a computational model for the rat and mouse. Dev Brain Res 151: 43-54.
- Wong, E. Y., J. Gohlke, W. C. Griffith, S. Farrow and E. M. Faustman (2004). Assessing the health benefits of air pollution reduction for children. Environ Health Perspect 112(2): 226-232.
- Gohlke, J.M, W. Griffith, S. Bartell, T. Lewandowski and E. Faustman (2002). A computational model for neocortical neuronogenesis predicts ethanol-induced neocortical neuron number deficits. Dev Neurosci 24(6): 467-477.