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Martin Young, DPhil

Martin Young, DPhil
 
Associate Professor
Med - Cardiovascular Disease
Zeigler Building, Room 308
1530 3rd Avenue South
Birmingham, Alabama 35294-0006
Email Address: meyoung@uab.edu   
Office Phone: (205) 934-2328 
Office Fax: (205) 975-5150
Web Site


Research Interests

  • Pathogenesis of myocardial contractile dysfunction observed during obesity and diabetes mellitus
  • Influence of environmental factors (time-of-day & nutrition) on cardiovascular health and disease 
  • Cardiomyocytes and the circadian clock 
  • Humoral factors: nutrients (glucose & fatty acids)
  • Increased fatty acid availability and the accumulation of intramyocellular fatty acid derivatives

Training

  • Postdoctoral Training: University of Texas-Houston, Boston University
  • Doctor of Philosophy (Biochemistry): University of Oxford
  • Master of Science: University of Oxford
  • Bachelor or Science: University of Oxford

Selected Journal Articles

  1. Kienesberger PC, Pulinilkunnil T, Sung MM, Nagendran J, Haemmerle G, Kershaw EE, Young ME, Light PE, Oudit GY, Zechner R, Dyck JR. Myocardial ATGL overexpression decreases the reliance on fatty acid oxidation and protects against pressure overload-induced cardiac dysfunction. Mol Cell Biol. 2012 Feb;32(4):740-50. Epub 2011 Dec 12. [PMID: 22158969]
  2. Durgan DJ, Pat BM, Laczy B, Bradley JA, Tsai JY, Grenett MH, Ratcliffe WF, Brewer RA, Nagendran J, Villegas-Montoya C, Zou C, Zou L, Johnson RL Jr, Dyck JR, Bray MS, Gamble KL, Chatham JC, Young ME. O-GlcNAcylation, novel post-translational modification linking myocardial metabolism and cardiomyocyte circadian clock. J Biol Chem. 2011 Dec 30;286(52):44606-19. Epub 2011 Nov 8. [PMID: 22069332]
  3. Ko ML, Shi L, Tsai JY, Young ME, Neuendorff N, Earnest DJ, Ko GY. Cardiac-specific mutation of Clock alters the quantitative measurements of physical activities without changing behavioral circadian rhythms. J Biol Rhythms. 2011 Oct;26(5):412-22. [PMID: 21921295]
  4. Durgan DJ, Tsai JY, Grenett MH, Pat BM, Ratcliffe WF, Villegas-Montoya C, Garvey ME, Nagendran J, Dyck JR, Bray MS, Gamble KL, Gimble JM, Young ME. Evidence suggesting that the cardiomyocyte circadian clock modulates responsiveness of the heart to hypertrophic stimuli in mice. Chronobiol Int. 2011 Apr;28(3):187-203. [PMID: 21452915]
  5. Bray MS, Young ME. Regulation of fatty acid metabolism by cell autonomous circadian clocks: time to fatten up on information? J Biol Chem. 2011 Apr 8;286(14):11883-9. Epub 2011 Feb 4. Review. [PMID: 21296875]