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Nicolas F. Berbari , Ph.D.
|The University of Alabama at Birmingham
Department of Cell Biology
Nutrition Obesity Research Center
McCallum Health Sciences Building, MCLM 683
University of Alabama at Birmingham
Birmingham, AL 35294
Phone: (205) 934-0995
Fax: (205) 934-0950
I earned a B.S. degree in Biology from Indiana University and received my Ph.D. in Integrated Biomedical Science from The Ohio State University. My dissertation focused on utilizing mouse models of the ciliopathy Bardet-Biedl Syndrome to study neuronal cilia.
I joined the laboratory of Bradley K. Yoder in the Department of Cell Biology in 2008. I am currently working on determining the role of primary neuronal cilia in feeding behavior. We are utilizing conditional and congenital knockout mouse models of ciliopathies, tissue culture, pharmacology and electrophysiology to address this question.
| Neuronal Cilia in Feeding Behavior
Panel A shows an obese mouse that has lost its cilia throughout the central nervous system (right) next to a wildtype littermate (left). Panel B shows a primary hypothalamic cultured neuron (neuronal marker β-Tubulin III in green) with a Mchr1 positive cilium in red.
- Sharma N., Kosan Z., Stallworth J.E., Berbari N.F., Yoder B.K. Soluble Levels of Tubulin Regulate Cilia Length Control. Mol Biol Cell. Mar;22(6):806-16. Epub 2011 Jan 26. [PMID: 21270438]
- Berbari N.F., Bishop G.A., Lewis J.S., Mykytyn K. Bardet-Biedl Syndrome Proteins are Required for G Protein-Coupled Receptor Localization to Neuronal Cilia. Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4242-6. Epub 2008 Mar 11. [PMID: 18334641]
- Berbari N.F., Askwith C.C., Lewis J.S., Mykytyn K. Identification of Ciliary Localization Sequences within the Third Intracellular Loop of G Protein-Coupled Receptors. Mol Biol Cell. 2008 Apr;19(4):1540-7. Epub 2008 Feb 6. [PMID: 18256283]
- Berbari N.F., Bishop G.A., Askwith C.C., Lewis J.S., Mykytyn K. Hippocampal neurons possess primary cilia in culture. Journal of Neuroscience Research. 2007. April; 85(5):1095-100 [PMID: 17304575]
- Bishop G.A., Berbari N.F., Lewis J.S., Mykytyn K. Type III adenylyl cyclase localizes to primary cilia throughout the adult mouse brain. Journal of Comparative Neurology. 2007 Dec 10;505(5):562-71. [PMID: 17924533]
- Doggett N.A., Xie G., Meincke L.J., Sutherland R.D., Mundt M.O., Berbari N.F., Davy B.E., Robinson M.L., Rudd M.K., Weber J.L., Stallings R.L., Han C. A 360-kb interchromosomal duplication of the human HYDIN locus. Genomics. 2006. Dec;88(6):762-71. [PMID: 16938426]
- Kelly L.E., Davy B.E., Berbari N.F., Robinson M.L., El-Hodiri H.M. Recombineered Xenopus tropicalis BAC expresses a GFP reporter under the control of Arx transcriptional regulatory elements in transgenic Xenopus laevis embryos. Genesis. 2005. 41(4):185-91. [PMID: 15789419]
- Lemon W.J., Swinton C.H., Wang M., Berbari N., Wang Y., You M. Single nucleotide polymorphism (SNP) analysis of mouse pulmonary adenoma susceptibility loci 1-4 for identification of candidate genes. Journal of Medical Genetics. 2003. 40(4):E36. [PMID: 12676909]
Years: 2008 -
Mentor(s): Bradley Yoder, Ph.D.