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Orlando Gutierrez, MD

Associate Professor
Nephrology, Department of Medicine
Phone: 205-996-2186

Dr. Gutiérrez is currently an Associate Professor of Medicine and head of the Section of Epidemiology and Outcomes Research in the Division of Nephrology at the University of Alabama at Birmingham. Using both epidemiologic and patient-oriented clinical research approaches, the primary focus of Dr. Gutiérrez’s group has been elucidating the mechanisms by which disorders of bone and mineral metabolism and nutrition impact outcomes in individuals with chronic kidney disease. He has received detailed training in human physiological studies including a Master’s degree in human clinical investigation from Harvard Medical School. In addition, Dr. Gutiérrez has a track record of publications, including prior feeding studies using physiological end-points, and other high-impact studies that have highlighted the associations of environmental and biological factors with outcomes in the general population and in individuals with CKD. This includes three funded projects that are currently using or have incorporated detailed feeding studies in healthy individuals or individuals with kidney disease (AHA 15SFDRN25620022, AHA 15SFRN2480000, R03 DK095005). This experience positions Dr. Gutiérrez to successfully serve as the principal investigator of this project.

Research/Clinical Interest

Mineral metabolism and outcomes
Using both epidemiological and patient-oriented physiological approaches, Dr. Gutierrez has concentrated his research efforts on the relationships between disturbances in mineral metabolism and clinical outcomes, focusing particularly on disorders of phosphorus and vitamin D metabolism and their associations with cardiovascular disease and mortality in kidney disease. He has a special interest in behavioral and environmental exposures that may modulate the impact of disordered mineral metabolism on health outcomes, particularly the emerging interface between socioeconomic status, nutrition, and mineral metabolism in health and in kidney disease. In addition to these efforts, Dr. Gutierrez is also examining the interconnections between disorders of iron and mineral metabolism, particularly as they relate to the management of anemia in patients with chronic kidney disease.

Selected Publications

  1. utierrez OM, Khodneva YA, Muntner P, Rizk DV, McClellan WM, Cushman M, Warnock DG, Safford MM. Association between urinary albumin excretion and coronary heart disease in black vs white adults. JAMA 2013;310(7):706-714. 23989654 
  2. Racial differences in albuminuria, kidney function, and risk of stroke. Gutiérrez OM, Judd SE, Muntner P, Rizk DV, McClellan WM, Safford MM, Cushman M, Kissela BM, Howard VJ, Warnock DG. Neurology. 2012 Oct 16;79(16):1686-92. 22993285 
  3. Gutiérrez OM, Farwell WR, Kermah D, Taylor EN. “Racial Differences in the Relationship Between Vitamin D, Bone Mineral Density and Parathyroid Hormone in the National Health and Nutrition Examination Survey.” Osteoporosis Int. 2010 20848081 
  4. Gutiérrez OM, Anderson A, Isakova T, Scialla J, Negrea L, Anderson AH, Bellovich K, Chen J, Robinson N, Ojo A, Lash J, Feldman HI, Wolf M. “Low Socioeconomic Status Associates with Higher Serum Phosphate Irrespective of Race.” J Am Soc Nephrol. 2010; 21: 1953-1960 20847142 
  5. Isakova T, Gutiérrez OM, Patel NM, Andress DL, Wolf M, Levin A. “Vitamin D Deficiency, Inflammation and Albuminuria in Chronic Kidney Disease: Complex Interactions.” J Renal Nutr. 2010 20817560 
  6. Isakova T, Gutiérrez OM, Smith K, Epstein M, Keating LK, Jüppner H, Wolf M. “Pilot Study of Dietary Phosphorus Restriction and Phosphorus Binders to Target Fibroblast Growth Factor 23 in Patients with Chronic Kidney Disease.” Nephrol Dial Transplant 2010 20631407 
  7. Gutiérrez OM, Wolf M. “Dietary Phosphorus Restriction in Advanced Chronic Kidney Disease: Merits, Challenges, and Emerging Strategies.” Semin Dial. 2010; 23(4): 401-6. 20557490 
  8. Gutiérrez OM, Isakova T, Enfield G, Wolf M. “Impact of Poverty on Serum Phosphate Concentrations in the Third National Health and Nutrition Examination Survey.” J Renal Nutr. May 2010 20537917 
  9. Gutiérrez OM, Isakova T, Smith K, Epstein M, Patel N, Wolf M. “Racial Differences in Postprandial Mineral Ion Handling in Health and in Chronic Kidney Disease.” Nephrol Dial Transplant June 2010 20530498 
  10. Gutiérrez OM. “Fibroblast Growth Factor 23 and Disordered Vitamin D Metabolism in Chronic Kidney Disease: Updating the “Trade-off” Hypothesis.” Clin J Am Soc Nephrol. 2010; 5(9): 1710-6. 20507957 
  11. Patel NM, Gutiérrez OM, Andress DL, Coyne DW, Levin A, Wolf M. “Vitamin D Deficiency and Anemia in Early Chronic Kidney Disease.” Kidney Int Apr 2010; 77:715-20. 20130525 
  12. Isakova T, Gutiérrez OM, Wolf M. “A blueprint for randomized trials targeting phosphorus metabolism in chronic kidney disease.” Kidney Int 2009; 76:705-16 19606082 
  13. Gutiérrez OM, Januzzi JL, Isakova T, Laliberte K, Smith K, Collerone G, Sarwar A, Hoffmann U, Coglianese E, Christenson R, Wang TJ, DeFilippi C, Wolf M. “Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Chronic Kidney Disease.” Circulation, 2009; 119:2545-2552 19414634 
  14. Lee PS, Kartik S, Karumanchi SA, Tamez H, Bhan I, Isakova T, Gutiérrez O, Wolf M, Chang Y, Stossel T, Thadhani R. “Plasma Gelsolin, Circulating Actin, and Chronic Hemodialysis Mortality.” J Am Soc Nephrol 2009; 20:1140-8 19389844 
  15. Isakova T, Gutiérrez OM, Chang Y, Shah A, Tamez H, Smith K, Thadhani R, Wolf M. “Phosphorus Binders and Survival on Hemodialysis.” J Am Soc Nephrol 2009;20:388-96 19092121 
  16. Gutiérrez OM, Mannstadt M, Isakova T, Rauh-Hain JA, Tamez H, Shah A, Smith K, Lee H, Thadhani R, Jüppner H, Wolf M. “Fibroblast Growth Factor 23 and Mortality among Hemodialysis Patients.” N Engl J Med 2008; 359:584-592 18687639 
  17. Gutiérrez OM, Tamez H, Bhan I, Zazra J, Tonelli M, Wolf M, Januzzi JL, Chang Y, Thadhani R. “N-terminal pro-B-type Natriuretic Peptide Concentrations in Hemodialysis Patients: Prognostic Value of Baseline and Follow-up Measurements.” Clin Chem 2008; 54: 1339-48 18539645 
  18. Wolf M, Betancourt J, Chang Y, Shah A, Teng M, Tamez H, Gutiérrez O, Camargo CA, Melamed M, Norris K, Stampfer MJ, Powe NR, Thadhani R. “Impact of Activated Vitamin D and Race on Survival among Hemodialysis Patients.” J Am Soc Nephrol 2008; 19:1379-88 18400938 
  19. Gutiérrez OM, Isakova T, Andress D, Levin A, Wolf, M. “Prevalence and Severity of Disordered Mineral Metabolism in Blacks with Chronic Kidney Disease.” Kidney Int 2008; 73: 956-962 18256597 
  20. Isakova T, Gutiérrez O, Shah A, Castaldo L, Holmes J, Lee H, Wolf M. “Postprandial Calcium and Phosphorus Metabolism in the Pathogenesis of Secondary Hyperparathyroidism in Early Chronic Kidney Disease.” J Am Soc Nephrol 2008; 19:615-623 18216315 
  21. Wolf M, Shah A, Gutiérrez O, Ankers E, Monroy M, Tamez H, Steele D, Chang Y, Camargo CA, Tonelli M, Thadhani R. “Vitamin D Levels and early mortality among incident hemodialysis patients.” Kidney Int 2007 72:1004-13; 2007 17687259 
  22. Yao J, Gutiérrez OM, and J Reiser. “Emphysematous Pyelonephritis.” Kidney Int 2007; 71:462-5; 2007 17136032 
  23. Gutiérrez OM and HY Lin. “Refractory Hyponatremia.” Kidney Int 2007; 71:79-82 16985516 
  24. Bhan I, Shah A, Holmes J, Isakova T, Gutiérrez O, Burnett SA, Jueppner H, Wolf, M. “Post-transplant hypophosphatemia: ‘Tertiary Hyper-Phosphatoninism?’”. Kidney Int 2006; 70:1486-94. 16941023 
  25. Gutiérrez O, Isakova T, Rhee E, Holmes J, Collerone G, Jueppner H, and M Wolf. “Fibroblast Growth Factor 23 Mitigates Hyperphosphatemia but Accentuates Calcitriol Deficiency in Chronic Kidney Disease.” J Am Soc Nephrol 2005; 16:2205-15. 15917335 
  26. Marcelino J, Carpten JD, Suwairi WM, Gutiérrez OM, Schwartz S, Robbins C, Sood R, Makalowska I, Baxevanis A, Johnstone B, Laxer RM, Zemel L, Kim CA, Herd JK, Ihle J, Williams C, Johnson M, Raman V, Alonso LG, Brunoni D, Gerstein A, Papadopoulos N, Bahabri SA, Trent JM, Warman ML. “CACP, Encoding a Secreted Proteoglycan, is Mutated in Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome.” Nature Genetics 1999; 23: 319-322. 10545950 
  27. Felgueiras J, Gutiérrez O, Tullius S, Tinckam K. “Reversible posterior leukoencephalopathy syndrome in a renal transplant patient.” Port J Nephrol Hypert 2008; 22: 201-204