Department of Nutrition Sciences
The University of Alabama at Birmingham
303 Shelby Biomedical Research Building
1875 University Boulevard
Birmigham, AL 35294-2182
Dr. Prabha Nagareddy obtained his B. Pharm and M. Pharm degrees from Bangalore University (1998) and RGUHS (2001) respectively from Bangalore, India. He then spent a year working as a pharmacologist in a pharmaceutical company before moving to Canada. In the fall of 2002, he joined the laboratory of Dr. John McNeill at the University of British Columbia and received his MSc (2004) and PhD (2009) degrees. Since his graduate training, Dr. Nagareddy is interested in understanding the molecular pathways that contribute to accelerated cardiovascular disease in diabetes. His MSc thesis research was primarily focused on studying the aberrant signaling mechanisms in blood vessels that contributed to impaired endothelial function, attenuated pressor responses to vasoactive agents and depressed blood pressure in animal models of type I diabetes. His doctoral research was aimed at understanding the mechanisms of insulin resistant hypertension in type 2 diabetes. He specifically studied the role of matrix metalloproteinase (MMPs) and the MMP-dependent epidermal growth factor receptor transactivation pathway in the development of insulin-resistant hypertension. During the entire time of his graduate research he was supported by funding from the Heart and Stroke Foundation of Canada and Michael Smith Foundation for Health Research.
Upon completing his PhD, Dr. Nagareddy moved to New York to commence a postdoctoral fellowship with Dr. Ira Goldberg at Columbia University. During this time, he was funded by a prestigious Canadian Institute of Health Research Fellowship. At Columbia, his postdoctoral work broadly focused on two main themes; mechanisms of accelerated atherosclerosis in diabetes and identification of the origins of adipose tissue macrophages in type 2 diabetes/ obesity. In collaborations with Drs. Alan Tall, Andrew Murphy and Ed Fisher, he discovered a novel role for the damage associated molecular patterns S100A8/A9 in hyperglycemia-accelerated atherosclerosis in diabetes. These findings which were published in the journal Cell Metabolism in 2013 laid the foundation for his future research work and a long-standing collaboration with Dr. Andrew Murphy at Baker IDI Heart and Diabetes Institute in Melbourne, Australia.
In 2013, Dr. Nagareddy joined the laboratory of Dr. Susan Smyth at the University of Kentucky (UK) and continued to work on exploring the mechanisms of myelopoiesis in obesity and its impact on adipose tissue inflammation, insulin resistance and cardiovascular disease. This work which also was the basis of his successful K99/R00 grant application specifically targeted the pathways that regulate myelopoiesis in the bone marrow (sterile inflammation). The findings from these studies were published once again in Cell Metabolism (2014) accompanied by editorials and cover page highlights. Lately in collaboration with Dr. Abdel-Latif, an interventional cardiologist at the UK and Andrew Murphy at Baker, he is studying the mechanisms of neutrophilia in conditions of acute myocardial ischemia. Further, in collaboration with his wife Dr. Beatriz Hanaoka, a Rheumatologist at UAB, he is exploring the molecular pathways that contribute to increased cardiovascular disease risk in Rheumatoid Arthritis (RA) patients.
In the May of 2016, he was recruited as an Assistant Professor by the Department of Nutrition Sciences at The University of Alabama at Birmingham. With these training experiences, he has expanded his research in exploring similar pathways that promote/mediate sterile inflammation in different disease settings such as acute myocardial ischemia, traumatic brain injury, stroke, rheumatoid arthritis etc.
His outside interests include reading, cooking, travelling and most importantly time with his wife and 2-year-old triplet girls.
- B. Pharm Pharmacy (Distinction), Bangalore University, India, 1998
- M. Pharm Pharmacology (Distinction), Rajiv Gandhi University of Health Sciences, India, Nov 2001
- M.Sc. Pharmaceutical Sciences, University of British Columbia (UBC), Canada, Nov 2004
- Ph.D. Pharmaceutical Sciences, University of British Columbia (UBC), Canada, Nov 2009
- Klyachkin YM, Nagareddy PR, Ye S, Wysoczynski M, Asfour A, Gao E, Sunkara M, Brandon JA, Annabathula R, Ponnapureddy R, Solanki M, Smyth SS, Ratajczak MZ, Morris AJ and Abdel-Latif A. Pharmacological elevation of circulating bioactive phosphor-sphingolipids enhances myocardial recovery after acute Infarction. Stem Cells Translational Medicine, 2015, 4(11):1333-43.
- Willecke F, Scerbo D, Nagareddy PR, Obunike JC, Barrett TJ, Abdillahi ML, Trent CM, Huggins LA, Fisher EA, Drosatos K, Goldberg IJ. Lipolysis, and not hepatic lipogenesis, is the primary modulator of triglyceride levels in streptozotocin-induced diabetic mice. Arteriosclerosis, Thrombosis and Vascular Biology, 2015, 35(1): 102-10. PMID: 25395613
- Nagareddy PR, Kraakman M, Masters SL, Stirzaker RA, Gorman DJ, Grant RW, Dragoljevic D, Hong ES, Abdel-Latif A, Smyth SS, Choi SH, Korner J, Bornfeldt KE, Fisher EA, Dixit VD, Tall AR, Goldberg IJ and Murphy AJ. Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. Cell Metabolism, 2014, 19(5): 821-835. PMID: 24807222 *Editorial: Obesity Corrupts Myelopoiesis: P.J. Murray. Cell Metabolism. 2014: 19:735-736. *Highlight: Recruiting inflammatory cell to fat. Nature Medicine. R Levinson. 2014: 20:594 *Highlight: Listed as “Top 10 Breakthroughs of the Decade “by Cell Metabolism. 2015
- Nagareddy PR, Asfour A, Klyachkin YM, Abdel-Latif A. A novel role for bioactive lipids in stem cell mobilization during cardiac ischemia: New paradigms in thrombosis: novel mediators and biomarkers. Journal of Thrombosis and Thrombolysis, 2014, 37(1): 24-31. PMID: 24318213
- Nagareddy PR, Murphy AJ, Stirzaker RA, Hu Y, Yu S, Miller RG, Ramkhelawon B, Distel E, Westerterp M, Huang LS, Schmidt AM, Orchard TJ, Fisher EA, Tall AR and Goldberg IJ. Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis. Cell Metabolism, 2013, 17(5): 695-708. PMID: 23663738 *Editorial: Hyperglycemia-Stimulated Myelopoiesis Causes Impaired Regression May 2016 Prabha R Nagareddy, PhD of Atherosclerosis in Type 1 Diabetes: M Brownlee. Cell Metabolism. 2013: 17(5): 631-633. *Highlight: This paper was highlighted on cover page of May 2013 issue
- Westerterp M, Murphy AJ, Wang M, Pagler TA, Vengrenyuk Y, Kappus MS, Gorman DJ, Nagareddy PR, Zhu X, Abramowicz S, Parks JS, Welch CL, Fisher EA, Wang N, Yvan-Charvet L, Tall AR. Deficiency of ABCA1 and ABCG1 in Macrophages Increases Inflammation and Accelerates Atherosclerosis in Mice. Circulation Research, 2013, 112(11): 1456-65. PMID: 23572498
- Tolani S, Pagler TA, Murphy AJ, Bochem AE, Abramowicz S, Welch C, Nagareddy PR, Holleran S, Hovingh GK, Kuivenhoven JA, Tall AR. Hypercholesterolemia and reduced HDL-C promote hematopoietic stem cell proliferation and monocytosis: Studies in mice and FH children. Atherosclerosis, 2013, 229(1): 79-85. PMID: 23684512
- Nagareddy PR and Smyth SS. Inflammation and thrombosis in cardiovascular disease. Current Opinion in Hematology, 2013, 20(5): 457-63. PMID: 23892572
- Goldberg IJ, Huang LS, Huggins LA, Yu S, Nagareddy PR, Scanlan TS, Ehrenkranz JR. Thyroid hormone reduces cholesterol via a non-LDL receptormediated pathway. Endocrinology, 2012,153(11): 5143-9. PMID: 22948212
- Nagareddy PR, Rajput PS, Vasudevan H, McClure B, Kumar U, MacLeod KM and McNeill JH. Inhibition of matrix metalloproteinase-2 improves endothelial function and prevents hypertension in insulin resistant rats. British Journal of Pharmacology, 2012,165(3): 705-15. PMID: 21740410
- Nagareddy PR, MacLeod KM and McNeill JH. GPCR agonist-induced transactivation of the EGFR upregulates MLC II expression and promotes hypertension in insulin resistant rats. Cardiovascular Research, 2010, 87(1): 177- 8. PMID: 20110336
- Nagareddy PR, Chow FL, Li H, Wang X, Nishimura T, MacLeod KM, McNeill JH and Fernandez–Patron C. Maintenance of adrenergic vascular tone by MMPtransactivation of the EGFR requires PI3K and mitochondrial ATP synthesis. Cardiovascular Research, 2009, 84(3): 368-77. PMID: 19578070 *Editorial: Vasoconstriction: tightening the noose through MMPs: Isenberg JS & Shiva S. Cardiovascular Research. 2009: 84(3): 339-4
- Nagareddy PR, Soliman H, Lin G, McNeill JH and MacLeod KM. Selective inhibition of protein kinase C β2 attenuates inducible nitric oxide synthase mediated cardiovascular abnormalities in streptozotocin-diabetic rats. Diabetes, 2009, 58(10): 2355-64. PMID: 19587355 May 2016 Prabha R Nagareddy, PhD
- Nagareddy PR, McNeill JH, Macleod KM. Chronic inhibition of inducible nitric oxide synthase ameliorates cardiovascular abnormalities in streptozotocin diabetic rats. European Journal of Pharmacology, 2009, 611:53–59. PMID: 19344709
- Soliman H, Craig GP, Nagareddy PR, Yuen V, Lin G, McNeill JH, Kumar U and MacLeod KM. Role of iNOS in induction of Rho A expression in hearts from diabetic rats. Cardiovascular Research, 2008, 9(2): 322-30. PMID: 18411229
- Xia Z, Kuo KH, Nagareddy PR, Wang F, Guo Z, Guo T, Jiang J, McNeill JH. Nacetylcysteine attenuates PKCbeta2 overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats. Cardiovascular Research, 2007, 73(4): 770-82. PMID: 17250813
- Nagareddy PR, Xia Z, MacLeod KM, McNeill JH. N-acetylcysteine prevents nitrosative stress-associated depression of blood pressure and heart rate in streptozotocin diabetic rats. Journal of Cardiovascular Pharmacology, 2006, 47(4): 513-20. PMID: 16680064
- Nagareddy PR, Xia Z, McNeill JH, MacLeod KM. Increased expression of iNOS is associated with endothelial dysfunction and impaired pressor responsiveness in streptozotocin-induced diabetes. American Journal of Physiology: Heart and Circulatory Physiology, 2005, 289(5): H2144-52. PMID: 16006542 *Highlight: Selected as “Top 10 Hidden Jewels in Cardiovascular Biology” by F1000 Biology
- Nagareddy PR, Vasudevan H, McNeill JH. Oral administration of sodium tungstate improves cardiac performance in streptozotocin-induced diabetic rats. Canadian Journal of Physiology and Pharmacology, 2005, 83(5): 405-11. PMID: 15897922
- Nagareddy PR, Lakshmana M. Withania somnifera improves bone calcification in calcium-deficient ovariectomized rats. Journal of Pharmacy and Pharmacology, 2006 Apr; 58(4): 513-9. PMID: 16597369
- Nagareddy PR, Lakshmana M. Assessment of experimental osteoporosis using CT-scanning, quantitative X-ray analysis and impact test in calcium deficient ovariectomized rats. Journal of Pharmacological and Toxicological Methods, 2005, 52(3): 350-5. PMID: 15996488
- Nagareddy PR, Lakshmana M, Udupa UV. Antiosteoporotic activity of OST-6 (Osteocare), a herbomineral preparation in calcium deficient ovariectomized rats. Phytotherapy Research, 2004, 18(1): 25-9. PMID: 14750196
- Nagareddy PR, Lakshmana M, Udupa UV. Effect of Praval bhasma (Coral calx), a natural source of rich calcium on bone mineralization in rats. Pharmacological Research, 2003, 48(6): 593-9. PMID: 14527824 May 2016 Prabha R Nagareddy, PhD
- Nagareddy PR, Lakshmana M. Prevention of bone loss in calcium deficient ovariectomized rats by OST-6, a herbal preparation. Journal of Ethnopharmacology, 2003, 84(2-3): 259-64. PMID: 12648824