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Tim R. Nagy, Ph.D.

Professor
Dept. of Nutrition Sciences
School of Health Professions
Office Address: WEBB 419
Phone: 205-934-4088
E-mail: tnagy@uab.edu
Curriculum Vitae

Dr. Nagy is a Professor of Nutrition Sciences and Director of the UAB Nutrition Obesity Research Center. He directs the UAB Small Animal Phenotyping Laboratory that is a resource for the UAB Nutrition Obesity Research Center, the UAB Diabetes Research Center, and the UAB Nathan Shock Center of Excellence in the Basic Biology of Aging. Dr. Nagy’s career research focus has targeted the role of energetics in the regulation of body weight since his doctoral research studies in 1987. His research has spanned studies on unique animal models of energy balance, ranging from fruitflies, zebrafish, snakes, lemmings, and mice, to studies of energy balance and body weight regulation in humans. In order to conduct many of these studies, Dr. Nagy had to develop and validate methods for the non-invasive determination of body composition. Dr. Nagy worked with two imaging companies to develop and validate dual-energy X-ray absorptiometry for small animal research. In addition to the validation of DXA for animals, he has validated their use in the pediatric population. Dr. Nagy has validated and published on the use of μCT and quantitative magnetic resonance (QMR), being the first to use this latter technique to measure in vivo body composition of fruitflies and zebrafish. He has developed MRI methods for the in vivo determination of brown adipose in mice. He is considered a leading authority in the area of body composition and energy balance in both animal models and humans.

Education:

Indiana University of Pennsylvania, Indiana, PA
BS, Biology, 1984

Indiana University of Pennsylvania, Indiana, PA
MS, Biology, 1988

University of Utah, Salt Lake City, UT
PhD, Biology, 1992

Post-Graduate Training:

University of Delaware, Newark, DE
Postdoctoral Fellow, Endocrinology

University of Alabama at Birmingham
Postdoctoral Fellow, Energy Metabolism and Body Composition, 1996

Research Description:

Dr. Nagy is a Professor of Nutrition Sciences. He directs the Small Animal Phenotyping Laboratory that a subcore of the UAB  Nutrition Obesity Research Center Animal Models Core. Dr. Nagy’s research is focused on three areas: (1) the regulation of body weight, (2) the development and validation of methods for phenotyping small animals, and (3) the link among body fat, caloric restriction and cancer.

Dr. Nagy’s studies on the regulation of body weight have utilized both humans and animal models. Currently his studies are focused on animal models to better understand the mechanisms regulating energy expenditure and thus body weight. These studies include antipsychotic drug-induced weight gain, the role of uncoupling proteins, and the role of dairy in weight loss and bone health.

During Dr. Nagy’s studies on the regulation of energy expenditure using animal models, he realized the need to improve the measurement of body composition in small animals, especially in vivo methods. Thus, he worked with two medical imaging companies to adapt human peripheral dual-energy X-ray absorptiometers (DXA) for use with mice. Dr. Nagy was the first to validate and publish on the use of DXA for measurements of fat, lean, and bone in mice. He has extended his interest in imaging techniques to that of peripheral quantitative computed tomography (pQCT). His studies have demonstrated that pQCT can be used to determine relative body fat and the relative fat content of organs in mice and rats. Recently, Dr. Nagy acquired a micro-computed tomography instrument and is currently validating its use for both hard and soft tissue. These non-invasive techniques are extremely useful and important tools for bone and obesity researchers using animal models in their research.

The final area of research interest is the link among body fat, caloric restriction, and cancer. Dr. Nagy has developed a mouse model in which energy intake can be held constant while body fat is modified by varying energy expenditure using ambient temperature. Thus multiple groups of mice, whose body fat are vastly different but food intake is the same, can be studied. This line of research will determine the independent effects of body fat on cancer.

Publications

  1. Nagy TR, and DH Pistole. 1988. The effects of fasting on some physiological parameters in the meadow vole, Microtus pennsylvanicus. Comp. Biochem. Physiol. 91A:679-684
  2. Berger PJ, NC Negus, AJ Pinter, and TR Nagy. 1992. Offspring growth and development responses to maternal transfer of 6-MBOA information in Microtus montanus. Can. J. Zool. 70:518-522.
  3. Gower BA, TR Nagy, and MH Stetson. 1992. Role of photoperiod in reproductive maturation and peripubertal hormone concentrations in male collared lemmings, Dicrostonyx groenlandicus. J. Reprod. Fertil. 96:153-163.
  4. Gower BA, TR Nagy, and MH Stetson. 1993. Role of prolactin and the gonads in seasonal physiological changes in the collared lemming (Dicrostonyx groenlandicus). J. Exp. Zool. 266:92-101.
  5. Nagy TR 1993. Effects of photoperiod history and temperature on male collared lemmings, Dicrostonyx groenlandicusJ. Mammal. 74:990-998.
  6. Nagy TR, and NC Negus. 1993. Energy acquisition and allocation in male collared lemmings (Dicrostonyx groenlandicus): Effects of photoperiod, temperature, and diet quality. Physiol. Zool. 66:537-560.
  7. Nagy TR, BA Gower, and MH Stetson. 1993. Threshold photoperiods for the induction of short day traits in the collared lemming (Dicrostonyx groenlandicus). J. Exp. Zool. 267:57-66.
  8. Nagy TR, BA Gower, and MH Stetson. 1993. Development of collared lemmings, Dicrostonyx groenlandicus, is influenced by pre- and postweaning photoperiods. J. Exp. Zool. 267:533-542.
  9. Gower BA, C Hadjipanayis, TR Nagy, and MH Stetson. 1994. Response of collared lemmings to melatonin: II. infusions and photoperiod. J. Pineal Res. 17:185-194.
  10. Gower BA, TR Nagy, and MH Stetson. 1994. Effect of photoperiod, testosterone, and estradiol on body mass, bifid claw size, and pelage color in collared lemmings (Dicrostonyx groenlandicus). Gen. Comp. Endocrinol. 93:459-470.
  11. Nagy TR, BA Gower, and MH Stetson. 1994. Response of collared lemmings to melatonin: I. implants and photoperiod. J. Pineal Res. 17:177-184.
  12. Nagy TR, BA Gower, and MH Stetson. 1994. Photoperiod effects on body mass, body composition, growth hormone, and thyroid hormones in male collared lemmings (Dicrostonyx groenlandicus). Can. J. Zool. 72:1726-1734.
  13. Gower BA, TR Nagy, and MH Stetson. 1994. Pre- and postnatal effects of photoperiod on collared lemmings (Dicrostonyx groenlandicus). Am. J. Physiol. 267:R879-R887.
  14. Goran MI, R Figueroa, A McGloin, V Nguyen, MS Trueth, and TR Nagy. 1995. Obesity in children: recent advances in energy metabolism and body composition. Obesity Res. 3:277-289.
  15. Nagy TR, BA Gower, and MH Stetson. 1995. Endocrine correlates of seasonal body mass changes in the collared lemming (Dicrostonyx groenlandicus).  Am. Zool. 35:246-258.
  16. Goran MI, and TR Nagy. 1996. Effect of pre-testing environment on measurement of metabolic rate in children. Int. J. Obesity 20:83-87.
  17. Goran MI, P Driscoll, R Johnson, TR Nagy, and G Hunter. 1996. Cross-calibration of body-composition techniques against dual-energy X-ray absorptiometry in young children. Am. J. Clin. Nutr. 63:299-305.
  18. Gower BA, TR Nagy, and MH Stetson. 1996. Influence of photoperiod, time, and sex on hormone concentrations in collared lemmings (Dicrostonyx groenlandicus). Gen. Comp. Endo. 101:53-62.
  19. Nagy TR, MI Goran, RL Weinsier, MJ Toth, Y Schutz, and ET Poehlman. 1996. Determinants of basal fat oxidation in healthy Caucasians. J. Appl. Physiol. 80:1743-1748.
  20. Pintaurro S, TR Nagy, CM Duthie, and MI Goran. 1996. Cross-calibration of fat and lean measurements by dual-energy X-ray absorptiometry to pig carcass analysis in the pediatric body weight range. Am. J. Clin Nutr. 63:293-298.
  21. Goran MI, G Hunter, TR Nagy, and R Johnson. 1997. Physical activity related energy expenditure and obesity in young children. Int. J. Obesity. 21:171-178.
  22. Goran MI, TR Nagy, M Treuth, C Trowbridge, C Dezenberg, A McGloin, and BA Gower. 1997. Visceral fat in white and African American prepubertal children. Am. J. Clin. Nutr. 65:1703-1708.
  23. Gower BA, TR Nagy, and MH Stetson. 1997. Alterations in testicular response to long photoperiod by exposure to transient short photoperiod in collared lemmings (Dicrostonyx groenlandicus). J. Reprod. Fertil. 109:257‑262.
  24. Nagy TR, BA Gower, CA Trowbridge, C Dezenberg, RM Shewchuk, and MI Goran. 1997. Effects of gender, ethnicity, body composition, and fat distribution on serum leptin concentration in children. J. Clin. Endocrinol. Metab., 82:2148-2152.
  25. Nagy TR, BA Gower, RM Shewchuk, and MI Goran. 1997. Serum leptin and energy expenditure in children. J. Clin. Endocrinol. Metab., 82:4149-4153.
  26. Trowbridge CA, BA Gower, TR Nagy, GR Hunter, MS Trueth, and MI Goran. 1997. Maximal aerobic capacity in African-American and Caucasian prepubertal children. Am. J. Physiol., 273:E809-E814.
  27. Goran MI, R Shewchuk, BA Gower, TR Nagy, WH Carpenter, and R Johnson. 1998. Longitudinal changes in body fat in Caucasian children: No effect of childhood energy expenditure. Am. J. Clin. Nutr., 67:309-316.
  28. Goran MI, BA Gower, TR Nagy, and RK Johnson. 1998. Developmental changes in energy expenditure and physical activity in children: Evidence for a decline in physical activity in girls prior to puberty. Pediatrics, 101: 887-891.
  29. Gower BA, TR Nagy, CA Trowbridge, C Dezenberg, and MI Goran. 1998. Fat distribution and insulin response in prepubertal African American and white children. Am. J. Clin. Nutr., 67:821-827.
  30. Nagy TR, SL Davies, GR Hunter, B Darnell, and RL Weinsier. 1998. Serum leptin concentrations and weight gain in post-obese, postmenopausal women. Obesity Res., 6:257-261.
  31. Sun M, BA Gower, TR Nagy, CA Trowbridge, C Dezenberg, and MI Goran. 1998. Total, resting and physical activity-related energy expenditure in Caucasian and African-American children. Am. J. Physiol., 37:E232-E237.
  32. Goran MI, BA Gower, M Treuth, and TR Nagy. 1998. Prediction of intra-abdominal and subcutaneous abdominal adipose tissue in healthy pre-pubertal children. Int. J. Obesity, 22:549-558.
  33. Goran MI, TR Nagy, BA Gower, M Mazariegos, N Solomons, V Hood, R Johnson. 1998. Influence of sex, seasonality, ethnicity and geographic location on the components of total energy expenditure in young children: implications for energy requirements. Am. J. Clin. Nutr., 68:675-682.
  34. Gower BA, TR Nagy, MI Goran, MJ Toth, and ET Poehlman. 1998. Fat distribution and plasma lipid-lipoprotein concentrations in pre- and postmenopausal women. Int. J. Obesity, 22:605-611.
  35. Gower BA, TR Nagy, and MH Stetson. 1998. Spontaneous testicular regression in collared lemmings (Dicrostonyx groenlandicus) exposed to prolonged long photoperiod. J. Reprod. Fertil., 113:307-313.
  36. Ku C-Y, BA Gower, TR Nagy, CB Stephensen, and MI Goran. 1998. Relationship between dietary fat, body fat, and serum lipid profile in prepubertal children. Obesity Res., 6:400-407.
  37. Dezenberg C, TR Nagy, BA Gower, R. Johnson, and MI Goran. 1999. Predicting body composition from anthropometry in pre-adolescent children. Int. J. Obesity, 23:253-259.
  38. Gower BA, TR Nagy, and MI Goran. 1999. Visceral fat, insulin sensitivity, and lipids in prepubertal children. Diabetes, 48:1515-1521.
  39. Sun M, BA Gower, TR Nagy, AA Bartolucci, and MI Goran. 1999. Do hormonal indices of maturation explain energy expenditure in African-American and Caucasian pre-pubertal children. Int. J. Obesity, 23: 1320-1326.
  40. Bhatnagar S, ME Bell, J Liang, L Soriano, TR Nagy, and MF Dallman. 2000. Corticosterone facilitates saccharin intake in adrenalectomized rats.  Does corticosterone increase stimulus salience? J. Neuroendocrinol., 12:453-460.
  41. Bell ME, S Bhatnagar, J Liang, L Soriano, TR Nagy, and MF Dallman. 2000. Voluntary sucrose ingestion, like corticosterone replacement, prevents the metabolic deficits of adrenalectomy. J. Neuroendocrinol., 12:461-470.
  42. Gower BA, TR Nagy, MI Goran, A Smith, and E Kent. 2000. Leptin in postmenopausal women: Influence of hormone therapy, insulin, and fat distribution. J. Clin. Endocrinol. Metab., 85:1770-1775.
  43. Nagy TR and A-L Clair. 2000. Precision and accuracy of dual-energy X-ray absorptiometry for determining in vivo body composition of mice. Obesity Res., 8:392-398.
  44. Weinsier RL, TR Nagy, GR Hunter, BE Darnell, DD Hensrud, and HL Weiss. 2000. Do adaptive changes in metabolic rate favor weight regain in weight-reduced individuals?  Examination of the set-point theory. Am. J. Clin. Nutr.,72:1088-1094.
  45. Kurtz DM, L Tian, BA Gower, TR Nagy, CA Pinkert, and PA Wood. 2000. Transgenic studies of fatty acid oxidation gene expression in nonobese diabetic mice. J. Lipid Res., 41:2063-2070.
  46. Nagy TR, CW Prince, and J Li. 2001. Validation of peripheral DXA for the measurement of bone mineral in intact and excised long bones of rats. J. Bone Mineral Res., 16:1682-1687.
  47. Secor SM, TR Nagy, KE Johnston, T Tamura. 2001. Effect of feeding on circulating micronutrient concentrations in the Burmese python (Python molurus). Comp. Biochem. Physiol., 129:673-9.
  48. Kumar MV, T Shimokawa, TR Nagy, and MD Lane. 2002. Differential effects of a centrally-acting fatty acid synthase inhibitor in lean and obese mice. Proc. Natl. Acad. Sci., 99:1921-1925.
  49. Gower BA, TR Nagy, ML Blaylock, C Wang, and L Nyman. 2002. Estradiol my limit lipid oxidation via Cpt1 expression and hormonal mechanisms.  Obesity Res., 10:167-172.
  50. Brix AE, A Elgavish, TR Nagy, BA Gower, WJ Rhead, and PA Wood. 2002. Evaluation of liver fatty acid oxidation in the leptin-deficient obese mouse. Mol. Genet. & Metab., 75:219-226.
  51. Nagy TR, D Kryzwanski, J Li, R Desmond, and S Meleeth. 2002. Effect of group versus single housing on phenotypic variance in C57BL/6J mice.  Obesity Res., 10:412-415.
  52. Powell CS, ML Blaylock, R Wang, HL Hunter, GL Johanning, and TR Nagy. 2002.  Effects of energy expenditure and Ucp1 on photoperiod-induced weight gain in collared lemmings.  Obesity Res., 10:541-550.
  53. Hunter HL and TR Nagy.  2002. Body composition in a seasonal model of obesity: longitudinal measures and validation of DXA. Obesity Res., 10:1180-1187.
  54. Rikke BA, JE Yerg III, ME Battaglia, TR Nagy, DB Allison, and TE Johnson. 2003. Strain variation in the response of body temperature to dietary restriction. Mech. Ageing and Develop. 124:663-678.
  55. Bale TL, KR Anderson, AJ Roberts, K-F Lee, TR Nagy, and WW Vale. 2003. Corticotropin-releasing factor receptor-2 deficient display abnormal homeostatic responses to challenges of increased dietary fat and cold. Endocrinology, 144:2580-2587.
  56. Alb JG Jr., JD Cortese, SE Phillips, RL Albin, TR Nagy, RL Albin, and VA Bankaitis. 2003. Mice lacking phosphatidylinositol transfer protein alpha exhibit spinocerebellar degeneration, intestinal and hepatic steatosis, and hypoglycemia. J. Biol. Chem.,278:33501-33518.
  57. 57. Secor SM and TR Nagy.  2003. Non-invasive measure of body composition of snakes using dual-energy X-ray absorptiometry.  Comp. Biochem. Physiol. A, 136:379-389.
  58. Wu X, MA McKenna, X Feng, TR Nagy, and JM McDonald. 2003. Osteoclast apoptosis: the role of Fas in vivo and in vitro. Endocrinology, 144:5545-5555.
  59. Goetzman ES, L Tian, TR Nagy, BA Gower, TR Schoeb, A Elgavish, EP Acosta, MS Saag, and PA Wood. 2003. HIV protease inhibitor ritonavir induces lipoatrophy in male mice. AIDS Res. Hum. Retroviruses, 19:1141-1150.
  60. Nagy TR, and MS Johnson.  2003. Measurement of relative body and liver fat in small animals using peripheral quantitative computed tomography. Int. J. Body Comp. Res., 1:155-160. PMCID:PMC3086261
  61. Ogilvie KM, R Saladin, TR Nagy, MS Urcan, RA Heyman, and MD Leibowitz.  2004. Activation of the retinoid X receptor (RXR) suppresses appetite in the rat.  Endocrinology, 145:565-73.
  62. Johnson MS, DP Onorato, BA Gower, and TR Nagy. 2004. Weight change affects leptin and corticosterone in the collared lemming. Gen. Comp. Endocrinol., 136:30-36.
  63. Nagy TR, ML Blaylock, and WT Garvey. 2004. Role of UCP2 and 3 in nutrition and obesity. Nutrition. 20:139-144.
  64. Rikke BA, JE Yerg, III, ME Battaglia, TR Nagy, DB Allison, and TE Johnson.  2004. Quantitative trait loci specifying the response of body temperature to dietary restriction.  J. Gerontology, 59A:118-125. (Note:This paper won the Samuel Goldstein Award from the Gerontological Society of America.  The award signifies the best paper published in the Journal each year.)
  65. Liu Z, W Shi, X Ji, C Sun, WSS Jee, Y Wu, Z Mao, TR Nagy, Q Li, and X Cao. 2004. Molecules mimicking Smad1/Hox interaction stimulate bone formation. J. Biol. Chem. 279:11313-11319.
  66. Pan G, X Wu, M McKenna, X Feng, TR Nagy, and JM McDonald. 2004. AZT enhances osteoclastogenesis and bone loss. AIDS Res. Hum. Retroviruses, 20:608-620.
  67. Blaylock ML, R Wang, D Shan, and TR Nagy.  2004. Ucp3 expression during weight gain and loss, cold exposure, and fasting in the collared lemming. Obesity Res., 12:1690-1697.
  68. Kumar S, G  Mahendra, TR Nagy, and S Ponnazhagan. 2004. Osteoblast differentiation of recombinant adeno-associated virus 2-transduced murine mesenchymal stem cells and development of an immunocompetent mouse model for ex vivo osteoporosis gene therapy.  Human Gene Therapy, 15:1197-1206.
  69. Cope MB, TR Nagy, JR Fernandez, N Geary, DE Casey, and DB Allison. 2005.  Antipsychotic drug-induced weight gain: development of an animal model. Int. J. Obesity, 29:607-614.
  70. Huffman DM, NM Landy, E Potter, TR Nagy, and BA Gower. 2005. Comparison of the Lunar DPX-L and Prodigy dual-energy X-ray absorptiometers for assessing total and regional body composition.  Int. J. Body Composition Res.,3:25-30. 
  71. Berrigan D, JA Lavigne, SN Perkins, TR Nagy, JC Barrett, and SD Hursting. 2005. Phenotypic effects of calorie restriction and insulin-like growth factor-1 treatment on body composition and bone mineral density of C57BL/6 mice: Implication for cancer progression. In vivo, 19:667-674.
  72. Johnson MS, NM Landy, EP Potter, and TR Nagy. 2005. Comparison of software versions for body composition analysis using the PIXImus dual-energy X-ray absorptiometer.  Int. J. Body Composition Res., 3:69-72.
  73. Chandrakeerthi CM, TR Nagy, J Lemons, and M McCracken. 2005. Dual-energy X-ray absotiometry (DXA) analysis of implants in rat tibiae. Implant Dent., 14:294-300.
  74. Chen A, B Brar, CS Choi, D Rousso, J Vaughan, U Kuperman, SN Kim, C Donaldson, SM Smith, C Li, TR Nagy, GI Shulman, KF Lee, and W Vale. 2006. Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle. PNAS,103:16580-16585. PMCID: PMC1637624.
  75. Huffman DM, MS Johnson, A Watts, A Elgavish, IA Eltoum, and TR Nagy. 2007. Cancer progression in the transgenic adenocarcinoma of mouse prostate mouse is related to energy balance, body mass, and body composition, but not food intake. Cancer Res., 67:417-424. *Note – the above paper was included in the “Cancer Research Highlights” section of the January issue
  76. Lin YL, WJS de Villiers, BA Garvey, SR Post, TR Nagy, FF Safadi, MC Faugere, G Wang, HH Malluche, and JP Williams. 2007.  The effect of class A scavenger receptor (SR-A) in bone. J. Biol. Chem., 282:4653-4660.
  77. Cope MB, P Jumbo-Lucioni, RG Walton, RA Kesterson, DB Allison, and TR Nagy. 2007. No effect of dietary fat on short-term weight gain in mice treated with atypical antipsychotic drugs. Int. J. Obesity, 31:1014-1022.
  78. Huffman DM, WE Grizzle, MM Bamman, J Kim, IA Eltoum, A Elgavish, and TR Nagy. 2007. SIRT1 is significantly elevated in mouse and human prostate cancer. Cancer Res., 67:6612-6618.
  79. Davenport JR, A Watts, VC Roper, MJ Croyle, T van Groen, JM Wyss, TR Nagy, RA Kesterson, and BK Yoder. 2007. Conditional disruption of intraflagellar transport in adult mice leads to hyperhagia-induced obesity and slow onset cystic kidney disease.  Current Biology,17:1586-1594. PMCID: PMC2084209.
  80. Cottone P, V Sabino, TR Nagy, DV Coscina, and EP Zorrilla. 2007. Feeding microstructure in diet-induced obesity susceptible and resistant rats: central effects of urocortin 2. J. Physiol.583:487-504. PMCID: PMC2277029.
  81. Johnson MS, P Jumbo-Lucioni, AJ Watts, DB Allison, and TR Nagy. 2007. Effect of dairy supplementation on body composition and insulin resistance in mice, Nutrition, 23:836-843.
  82. Huffman DM, DR Moellering, WE Grizzle, CR Stockard, MS Johnson, and TR Nagy. 2008. Effect of exercise and calorie restriction on biomarkers of aging in mice. Am. J. Physiol. 294:R1618-1627.
  83. Chopra PM, M Johnson, TR Nagy, and JE Lemons. 2008. Micro-computed tomographic analysis of bone dealing subsequent to graft placement. J. Biomed. Mat. Res (B),88B:611-618.
  84. Cope MB, X Li, P Jumbo-Luciono, CA DiCostanzo, WB Jamison, RA Kesterson, DB Allison, and TR Nagy. 2009. Risperidone alters food intake, core body temperature, and locomotor activity in mice. Physiol. Behav, 96:457-63. PMCID: PMC269091
  85. Smith DL Jr, MS Johnson, and TR Nagy. 2009. Precision and accuracy of bioimpedance spectroscopy for determination of in vivo body composition of rats. Int. J. Body Composition Research, 7:21-26. PMCID: PMC2722071.
  86. Jones AS, MS Johnson, and TR Nagy. 2009. Validation of quantitative magnetic resonance for the determination of body composition of mice. Int. J. Body Comp. Res., 7:67-72. PMCID: PMC2868277.
  87. Tang Y, X Wu, W Lei, L Pang, C Wan, Z Shi, L. Zhao, TR Nagy, X Peng, J Hu, X Feng, W Van Hul, M Wan, and X Cao. 2009. TGF-β1-induced migration of bone mesenchymal stem cells couples bone resorption and formation. Nature Medicine, 15:757-765. PMCID:PMC2727637
  88. Meeran SM, T Singh, TR Nagy, and SK Katiyar. 2009. High-fat diet exacerbates inflammation and cell survival signals in the skin of ultraviolet B-irradiated mice. J. Toxicology and Applied Pharmacology, 241:303-10. PMID:19747500
  89. Johnson MS, DL Smith Jr, and TR Nagy. 2009. Validation of quantitative magnetic resonance (QMR) for determination of body composition in rats. Int J Body Comp Res., 7:99-107. PMCID: PMC2914623.
  90. Li X, MB Cope, MS Johnson, DL Smith, Jr., and TR Nagy. 2010. Mild calorie restriction induces fat accumulation in female C57Bl/6J mice. Obesity, 18:456-62. PMCID: PMC288016.
  91. Smith DL Jr, TR Nagy, LS Wilson, S Barnes, S Dong, DG Pritchard, and DB Allison. 2010. The effect of mannan oligosaccharide supplementation on body weight gain and fat accrual in C57Bl/6 mice. Obesity, 18:995-9. PMCID: PMC3073505.
  92. Kumar S, TR Nagy, and S Ponnazhagan. 2010. Therapeutic potential of genetically modified adult stem cells for osteopenia. Gene Therapy, 17:105-16. PMCID: PMC2941444.
  93. Casazza K, A Willig, BA Gower, TR Nagy, GR Hunter, S Wallace, M Amaya, F Franklin, M Beasley, and JR Fernandez. 2010. The role of genetic background in the etiology of disease risk in children- Are the effects mediated by excessive fat accumulation? J Pediatrics, 157:50-56.e1. PMCID: PMC3119818.
  94. Hu HH, DL Smith Jr, KS Nayak, MI Goran, and TR Nagy. 2010. Identification of brown adipose tissue in mice with rapid fat-water magnetic resonance imaging.  J Magn. Reson. Imaging, 31:1195-1202. PMCID: PMCID: PMC3509746.
  95. Siccardi AJ III, S Padgett-Vasquez, HW Garris, WT Jones, TR Nagy, LR D’Abramo, and SA Watts. 2010. Dietary strontium increases bone mineral density in intact zebrafish (Danio rerio): a potential model system for osteoporosis research. Zebrafish, 7:267-73. PMCID: PMC3117238.
  96. Smith DL Jr, H Robertson, R Desmond, TR Nagy, and DB Allison. 2010. No compelling evidence that sibutramine prolongs life in rodents despite providing a dose-dependent reduction in body weight. Int J Obesity, 35:652-7. PMCID: PMC3091992.
  97. Eccleston HG, KK Andringa, AM Betancourt, AL King, SK Mantena, TM Swain, HN Tinsley, RN Nolte, TR Nagy, GR Abrams, and SM Bailey. 2011. Chronic exposure to a high fat diet induces hepatic steatosis, impairs nitric oxide bioavailability, and modifies the mitochondrial proteome in mice. Antioxid Redox Signal, 15:447-59. PMCID: PMC3118652.
  98. Azrad M, P-L Chang, BA Gower, GR Hunter, and TR Nagy. 2011. Reduced mitogenicity of sera following weight loss in premenopausal women. Nutr Cancer, 63:916-23. PMCID: PMC3209713.
  99. Carroll WF, J Fabres, TR Nagy, M Frazier, C Roane, F Pohlandt, WA Carlo, and UH Thome.  2011. Results of extremely low birth weight infants randomized to receive extra enteral calcium supply. J Ped Gastro & Nutr. 53:339-45. PMCID: PMC3162470.
  100. Nyman LR, L Tian, DA Hamm, TR Schoeb, BA Gower, TR Nagy, and PA Wood. 2011. Long-term effects of high-fat or high-carbohydrate diets on glucose tolerance in mice with heterozygous carnitine palmitoyltransferase-1a deficiency. Nutrition and Diabetes, 1, e14. PMCID: PMC325127
  101. Hu HH, Y Li, TR Nagy, MI Goran, and KS Nayak. 2011. Quantification of absolute fat mass by magnetic resonance imaging: a validation study against chemical analysis. Int J Body Composition Res, 9:111-122. PMCID: PMC3509746
  102. Azrad M, BA Gower, GR Hunter, and TR Nagy. 2012. Intra-abdominal adipose tissue is independently associated with sex-hormone binding globulin in premenopausal African-American and European American women. Obesity, 20:1012-5. PMCID: PMC3626111
  103. Azrad M, BA Gower, GR Hunter, and TR Nagy. 2012. Racial differences in adiponectin and leptin in healthy premenopausal women.  Endocrine, 43:586-92. PMCID: PMC3541432
  104. Yang Y, DL Smith Jr., HH Hu, G Zhai, and TR Nagy. 2013. Chemical-shift water-fat MRI of white adipose depots: Inability to resolve cell size differences. Int J Body Composition Res, 11:9-16. PMCID: PMC3649013
  105. Li X and TR Nagy. Atypical antipsychotic drugs inhibit trabecular bone accrual in C57BL/6J mice. 2013. Int J Body Composition Res. 11:21-24. PMCID: PMC4023556
  106. Li X, MS Johnson, DL Smith Jr., Y Li, RA Kesterson, DB Allison, and TR Nagy. 2013. Effects of risperidone on energy balance in female C57BL/6J mice. Obesity, 21:1850-57.  PMCID: PMC3657586
  107. Cottone P, V Sabino, TR Nagy, DV Coscina, BE Levin, and EP Zorrilla. 2013. Centrally administered urocortin 2 decreases gorging on high-fat diet in genetically prone diet-induced obese rats.  Int J Obesity, 37:1515-23. PMCID: PMC3706508
  108. Smith DL Jr, Y Yang, HH Hu, G Zhai, and TR Nagy. 2013. Measurement of interscapular brown adipose tissue of mice in differentially housed temperatures by chemical shift magnetic resonance imaging. J Magn Reson Imaging, 38:1425-33. PMCID: PMC3856180.
  109. Zanghi BM, Cupp C, Pan Y, Tissot-Farve D, Milgram NW, Nagy TR, and H Dobson. 2013.  Noninvasive measurements of body composition and body water via quantitative magnetic resonance, deuterium water, and dual-energy x-ray absorptiometry in cats. Am J Vet Res, 74:721-732. PMCID exempt.
  110. Zanghi BM, Y Pan, DG Tissot-Favre, NW Milgram, TR Nagy, and H Dobson. 2013. Noninvasive measurements of body composition and body water via quantitative magnetic resonance, deuterium water, and dual-energy x-ray absorptiometry in awake and sedated dogs. Am J Vet Res, 74:733-743. PMCID exempt.
  111. Berbari NF, RC Pasek, EB Malarkey, SM Yazdi, AD McNair, WR Lewis, TR Nagy, RA Kesterson, and BK Yoder. 2013. Leptin resistance is a secondary consequence of the obesity in ciliopathy mutant mice. Proc Natl Acad Sci USA, 110:7796-801. PMCID: PMC3651481
  112. Smith DL Jr, RJ Berry, ML Powell, TR Nagy, LR D’Abramo, and SA Watts. 2013. Dietary protein source influence on body size and composition in growing Zebrafish (Danio rerio).  Zebrafish, 10:439-46. PMCID:PMC3760061
  113. Ifere GO, R Desmond, W Demark-Wahnefried, and TR Nagy. 2013. Apolipoptrotein E gene polymorphism influences aggressive behavior in prostate cancer cells by deregulating cholesterol homeostasis. Int J Oncology, 43:1002-1010. PMCID: PMC3829771
  114. Virk-Baker MK, MY Martin, RS Levine, X Wang, TR Nagy, and M Pisu. 2013. Mammography utilization among Black and White Medicare beneficiaries in high breast cancer mortality US counties. Cancer Causes and Control, 24:2187-96. PMCID: PMC3955601.
  115. Virk-Baker M, S Barnes, H Krontiras, and TR Nagy. 2014. S-(-)equol producing status is not associated with breast cancer risk among low isoflavone consuming US postmenopausal women undergoing a physician recommended breast biopsy. Nutrition Research, 34:116-25. PMCID: PMC4028846.
  116. Kim T, L He, MS Johnson, Y Li, L Zeng, Y Ding, Q Long, JF Moore, JD Sharer, TR Nagy, ME Young, PA Wood, and Q Yang. 2014. Carnitine palmitoyltransferase 1b deficiency protects mice form diet-induced insulin resistance.  J Diabetes Metab 5:361. doi: 10.4172/2155-6156.1000361. PMCID: PMC4190034
  117. Yang Y, DL Smith Jr, KD Keating, DB Allison, and TR Nagy. 2014. Variations in body weight, food intake and body composition after long-term high-fat feeding in C57BL/6J mice. 2014. Obesity 22:2147-55, PMCID: PMC4180788.
  118. Allison DB, LH Antoine, SW Ballinger, MM Bamman, P Biga, VM Darley-Usmar, G Fisher, JM Gohlke, GV Halade, JL Hartman IV, GR Hunter, JL Messina, TR Nagy, EP Plaisance, KA Roth, MW Sandel, TS Schwartz, DL Smith Jr, D Sweatt, TO Tollefsbol, SA Watts, Y Yang, J Zhang, and SN Austad. 2014. Aging and energetics’ “Top 40” future research opportunities 2010-2013.[v1; ref status: indexed, http://f1000r.es/4ae] F1000Research 2014, 3:219 (doi: 10.12688/f1000research.5212.1) PMCID: PMC4197746
  119. Chusyd DE, D Wang, DM Huffman, and TR Nagy. 2016. Relationships between rodent white adipose tissue fat pads and human adipose fat depot.  Front. Nutr. 3:10. Doi:10.3389/fnut.2016.00010.  PMCID: PMC4835715.
  120. Lambert LJ, AK Challa, A Niu, L Zhou, J Tucholski, MS Johnson, TR Nagy, AW Eberhardt, PN Estep, RA Kesterson, and JM Grams. 2016. Increased trabecular bone and improved biomechanics in an osteocalcin null rat model created by CRISPR/Cas9 technology. Disease Model & Mechanisms, 9(10): 1169-1179. PMCID: PMC5087831.
  121. Frihauf JB, EM Fekete, TR Nagy, BE Levin, and EP Zorrilla. 2016. Maternal Western diet promotes obesity in male offspring of obesity-resistant rat dams: early endocrine markers.  Am J Physiol, 311(6):R1045-R1059. PMID:27654396.
  122. Ejima K, P Li, DL Smith Jr, TR Nagy, I Kadish, T van Groen, JA Dawson, Y Yang, A Patki, and DB Allison. 2016. Observational research rigor alone does not justify causal inference.  Eur J Clin Res, 46(12): 985-93. PMCID: PMC5118066.
  123. Johnson MS, RJ Watts, HS. Hammer, TR Nagy, and SA Watts. 2017. Validation of duel-energy X-ray absorptiometry (DXA) to predict body composition of channel catfish, Ictalurus punctatus. J World Aquaculture Soc, 48:122-131. PMCID: PMC5365081.
  124. Warner DA, MS Johnson, and TR Nagy. 2017. Validation of body condition indices and quantitative magnetic resonance in estimating body composition in a small lizard.  J Exp Zool A, 325(9):588-597. PMCID: PMC5349178.
  125. Davis RAH, JE Halbrooks, EE Watkins, G Fisher, GR Hunter, TR Nagy, and EP Plaisance. 2017. High-intensity interval training and calorie restriction promote remodeling of glucose and lipid metabolism in diet-induced obesity.  Am J Physiol, Jun 6:ajpendo.00445.2016. doi: 10.1152/ajpendo.00445.2016. [Epub ahead of print].
  126. Smith DL Jr, Y Yang, TR Nagy, A Patki, JR Vasselli, Y Zhang, and DB Allison. Weight cycling increases longevity compared with sustained obesity in mice.  Submitted.