Molecular & Cellular Pathology
SHEL 614 Zip 2182
Phone: (205) 996-6293
Dr. Chen received her BS degree from Fudan University and her Ph.D. from Xiamen University. She completed postdoctoral training and was appointed as a research instructor at the University of Vermont, School of Medicine. Dr. Chen joined the faculty of Department of Pathology at UAB in June 2004. She is currently a tenured Professor in Molecular and Cellular Pathology as well as a Principal Investigator at the Birmingham VA Medical Research Division. Dr. Chen serves as an editorial board member for Arteriosclerosis, Thrombosis and Vascular Biology (ATVB). She is a Fellow of the American Heart Association (AHA) and a member of Committee for Scientific Sessions Planning (CSSP) Committee of the AHA/ATVB council. Dr. Chen has served the NIH Atherosclerosis and Inflammation of the Cardiovascular System (AICS) and Vascular cell and Molecular Biology (VCMB) study sections as an Ad Hoc reviewer in the past few years, and she is currently a regular member of the VCMB study section.
Gene Regulation and Function in the Pathogenesis of Disease
Regulation of vascular smooth muscle cells (VSMC) contributes significantly to the development of cardiovascular diseases, including atherosclerosis and pulmonary hypertension. Vascular calcification is a feature of advanced atherosclerosis, a process of differentiation of VSMC to “bone-like” cells that resembles the process of osteogenesis. Increased oxidative stress accelerates the progression of atherosclerosis and vascular calcification. Projects involve characterization of molecular signals that regulates osteogenic transcription factor Runx2 in vascular calcification, as well as mechanisms underlying Runx2 in modulating the pathogenesis of atherosclerosis and vascular calcification. We have also discovered that calcifying vascular smooth muscle cells produce RANKL, which promotes macrophage infiltration and formation of vascualr osteoclasts in close apposition of calcified atherosclerotic lesions. We use cell culture systems and conditional knock out mouse models to elucidate the molecualr mechanisms of vascular calcification and vascualr osteoclastogenesis, which may lead to novel strategies and targets to treat atherosclerosis. In cancer biology, we have been investigating the molecular mechanisms by which calmodulin regulates death receptor signaling pathways in tumorigenesis. Currently, we are elucidating molecular mechanisms of resistance of pancreatic cancer to therapy with anti-death receptor 5 antibody. These studies will define novel mediators in the apoptotic machinery, and may lead to identification of new compounds that overcome drug resistance.
UAB’s Yabing Chen named a VA Research Career Scientist
Yabing Chen, Ph.D., pathology professor and research scientist at Birmingham VA Medical Center, has received a Research Career Scientist Award from the U.S. Department of Veterans Affairs. It provides five years of salary support in recognition of outstanding achievements and contributions to VA research.
UAB News, by Jeff Hansen, June 07, 2016