Kasturi Mitra, PhD
Exploring the significance of mitochondrial structural change in health and disease
Mitochondria are the cellular organelles that became the seat of energy production and intermediary metabolism during the course of evolution of eukaryotic cells. They are also crucial players in redox balance, calcium homeostasis, lipid modification and regulation of cell death in various developmental contexts. In various cells mitochondrial structure has been found to be dynamic. They exist in different inter-convertible forms resulting from fission-fusion events between individual mitochondria, significance of which is far from clear. My long term interest lies in understanding the structure-function relationship of these multifunctional organelles. A set of proteins that govern either fusion or fission of mitochondrial inner and outer membranes have been characterized and it is their activities that decide the steady state mitochondrial morphology in a cell; when fission dominates mitochondria remain as small fragmented elements and when fusion dominates mitochondria remain coalesced into larger hyperfused forms. We use various kinds of biochemical, cell biological, microscopy and genetic tools to understand the significance of mitochondrial dynamism in cell proliferation. Specifically we want to understand if the mitochondrial fission-fusion proteins can regulate cell proliferation in stem cells or deregulate it during tumorigenesis.
- Mitochondrial fission-fusion as an emerging key regulator of cell proliferation and differentiation.
Bioessays. Bioessays. 2013 Aug 14. doi: 10.1002/bies.201300011. [Epub ahead of print]
- DRP1-dependent mitochondrial fission initiates follicle cell differentiation during Drosophila oogenesis.
Mitra K, Rikhy R, Lilly M, Lippincott-Schwartz J.
J Cell Biol. 2012 May 14;197(4):487-97. doi: 10.1083/jcb.201110058. 22584906
- Mitochondria supply membranes for autophagosome biogenesis during starvation.
Hailey DW, Rambold AS, Satpute-Krishnan P, Mitra K, Sougrat R, Kim PK, Lippincott-Schwartz J.
Cell. 2010 May 14;141(4):656-67. doi: 10.1016/j.cell.2010.04.009. 20478256
- Analysis of mitochondrial dynamics and functions using imaging approaches.
Mitra K, Lippincott-Schwartz J.
Curr Protoc Cell Biol. 2010 Mar;Chapter 4:Unit 4.25.1-21. doi: 10.1002/0471143030.cb0425s46. 20235105
- A hyperfused mitochondrial state achieved at G1-S regulates cyclin E buildup and entry into S phase.
Mitra K, Wunder C, Roysam B, Lin G, Lippincott-Schwartz J.
Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):11960-5. doi: 10.1073/pnas.0904875106. Epub 2009 Jul 15. 19617534