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Ambika P. Ashraf, MD

Ambika Ashraf, MBBS, DCH, MD
Department of Pediatrics/Pediatric Endocrinology
CPP M30, 1601, 4th Ave S
Birmingham, AL 35243
Tel: (205) 638-9107
Fax: (205) 638-9821
Web Site


  • Medical School
    University of Calicut, Kerala, India
  • Residencies
    University of Calicut, India / Bronx - Lebanon Hospital; Teaching affiliate of Albert Einstein College of Medicine of Yeshiva University / Children's Hospital, University of Alabama at Birmingham
  • Fellowship
    Children's of Alabama, University of Alabama at Birmingham

Clinical Interests

Lipid disorder, disorders of bone metabolism including calcium and vitamin D, diabetes mellitus, pituitary and thyroid disorders, precocious puberty and other endocrine disorders of children and adolescents

Research Interests

Diabetes mellitus, Lipid metabolism, Disorders of calcium and vitamin D.


Publicatons at the PubMed

  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • pre 2011
  1. Sethuraman U, Zidan MA, Hanks L, Bagheri M, Ashraf A. Impact of vitamin D treatment on 25 hydroxy vitamin D levels and insulin homeostasis in obese African American adolescents in a randomized trial. J Clin Transl Endocrinol. 2018 Mar 26;12:13-19. doi: 10.1016/j.jcte.2018.03.002. eCollection 2018 Jun. PMID: 2989256
  2. Valaiyapathi B, Gower B, Ashraf AP. Pathophysiology of Type 2 diabetes in Children and Adolescents. Curr Diabetes Rev. 2018 Jun 7. doi: 10.2174/1573399814666180608074510. [Epub ahead of print] PMID: 29879890
  3. Dowla S, Aslibekyan S, Goss A, Fontaine K, Ashraf AP. Dyslipidemia is associated with pediatric nonalcoholic fatty liver disease. J Clin Lipidol. 2018 Apr 3. pii: S1933-2874(18)30194-6. doi: 10.1016/j.jacl.2018.03.089. [Epub ahead of print] PMID: 29699915
  4. Dowla S, Pendergrass M, Bolding M, Gower B, Fontaine K, Ashraf A, Soleymani T, Morrison S, Goss A. Effectiveness of a carbohydrate restricted diet to treat non-alcoholic fatty liver disease in adolescents with obesity: Trial design and methodology. Contemp Clin Trials. 2018 May;68:95-101. doi: 10.1016/j.cct.2018.03.014. Epub 2018 Mar 27. PMID: 29601997
  5. Fernandez TF, Ashraf AP. An Unusual Case of Galactorrhea With Normal Serum Prolactin. Clin Pediatr (Phila). 2018 Feb;57(2):238-240. doi: 10.1177/0009922816685821. Epub 2017 Jan 5. No abstract available. PMID: 28056542
  1. Valaiyapathi B, Ashraf AP.
    Hospital Management of Severe Hypertriglyceridemia in Children. Curr Pediatr Rev. 2017;13(4):225-231. doi: 10.2174/1573400514666180117092707. Review. PMID: 29345595
  2. Valaiyapathi B, Sunil B, Ashraf AP. Approach to Hypertriglyceridemia in the Pediatric Population. Pediatr Rev. 2017 Sep;38(9):424-434. doi: 10.1542/pir.2016-0138. Review. Erratum in: Pediatr Rev. 2017 Oct;38(10 ):498. PMID: 28864733
  3. Ashraf AP, Hurst ACE, Garg A. Extreme hypertriglyceridemia, pseudohyponatremia, and pseudoacidosis in a neonate with lipoprotein lipase deficiency due to segmental uniparental disomy. J Clin Lipidol. 2017 May - Jun;11(3):757-762. doi: 10.1016/j.jacl.2017.03.015. Epub 2017 Apr 3. PMID: 28438574
  4. Saadoon A, Ambalavanan N, Zinn K, Ashraf AP, MacEwen M, Nicola T, Fanucchi MV, Harris WT. Effect of Prenatal versus Postnatal Vitamin D Deficiency on Pulmonary Structure and Function in Mice. Am J Respir Cell Mol Biol. 2017 Mar;56(3):383-392. doi: 10.1165/rcmb.2014-0482OC. PMID: 27870560
  1. Mercer S, Hanks L, Ashraf A. Rhabdomyolysis in Pediatric Patients With Diabetic Ketoacidosis or Hyperglycemic Hyperosmolar State: A Case Series. Glob Pediatr Health. 2016 Nov 30;3:2333794X16671391. doi: 10.1177/2333794X16671391. eCollection 2016. No abstract available. PMID: 28229089
  2. Vaid S, Hanks L, Griffin R, Ashraf AP. Body mass index and glycemic control influence lipoproteins in children with type 1 diabetes. J Clin Lipidol. 2016 Sep-Oct;10(5):1240-7. doi: 10.1016/j.jacl.2016.07.010. Epub 2016 Aug 6. PMID: 27678442
  3. Hanks L, Pelham JH, Vaid S, Casazza K, Ashraf AP. Overweight adolescents with type 2 diabetes have significantly higher lipoprotein abnormalities than those with type 1 diabetes. Diabetes Res clin Pract.2016 May;115:83-9
  1. Jeffrey L. Tapley, Gerald McGwin Jr., Ambika P. Ashraf, Paul A. MacLennan, Koula Callahan, Karen Searcey, C. Douglas Witherspoon1, Jinan Saaddine and Cynthia Owsley, Feasibility and efficacy of diabetic retinopathy screening among youth with diabetes in a pediatric endocrinology clinic: a cross-sectional study, Diabetology & Metabolic Syndrome (2015) 7:56, PMID: 26136849.
  2. Diabetes and pre-diabetes significantly higher in morbidly obese children compared to obese children. Propst M, Colvin C, Griffin RL, Sunil B, Harmon CM, Yannam G, Johnson JE, Smith CB, Lucas AP, Diaz BT, Ashraf AP. Endocr Pract. 2015 Jun 29. PMID: 26121438.
  3. Hanks LJ, Gutiérrez OM, Bamman MM, Ashraf A, McCormick KL, Casazza K. Circulating levels of fibroblast growth factor-21 increase with age independently of body composition indices among healthy individuals. J Clin Transl Endocrinol. 2015 Jun 1;2(2):77-82. PMID: 26042208.
  4. Hanks LJ, Gutiérrez OM, Ashraf AP, Casazza K, Bone Mineral Content as a Driver of Energy Expenditure in Prepubertal and Early Pubertal Boys. J Pediatr. 2015 Apr 1. PMID:25841541
  5. Luong DQ, Oster R, Ashraf AP. Metformin treatment improves weight and dyslipidemia in children with metabolic syndrome. J Pediatr Endocrinol Metab. 2015 May; 28 (5-6): 649-55, PMID: 25210757.
  6. Patel SJ, Hanks LJ, Ashraf AP, Gutierrez OM, Bamman MM and Casazza K. Effects of 8 week resistance training on lipid profile and insulin levels in overweight/obese peri-pubertal boys-a pilot study. J Diab Res Clin Met. 2015; 4:2.
  1. Ashraf AP, Alvarez JA, Dudenbostel T, Calhoun D, Griffin R, Wang X, Hanks LJ, Gower BA. PLoS One. 2014 Dec 5;9(12):e114689, Associations between Vascular Health Indices and Serum Total, Free and Bioavailable 25-Hydroxyvitamin D in Adolescents. PMID: 25479358.
  2. Colvin CW, Ashraf AP, Griffin RL, Diaz BT, Yannam GR, Johnson JE, Lucas AP, Propst M, Harmon CM. Diabetes Status and Race are Associated with Cardiovascular Risk Markers in Obese Adolescents. Endocr Pract. 2014 Oct 8:1-21. PMID: 25297661.
  3. Hanks LJ, Casazza K, Ashraf AP, Wallace S, Gutiérrez OM, Fibroblast growth factor-21, body composition, and insulin resistance in pre-pubertal and early pubertal males and females. Clin Endocrinol (Oxf). 2014 Jul 10, PMID: 25039824.
  4. Ashraf AP, Huisingh C, Alvarez JA, Wang X, Gower BA; Insulin resistance indices are inversely associated with vitamin D binding protein concentrations. J Clin Endocrinol Metab. 2014 Jan;99(1):178-83. PMID: 24170105.
  1. Le PT, Huisingh CE, Ashraf AP.; Glycemic control and diabetic dyslipidemia in adolescents with type 2 diabetes.; Endocr Pract. 2013 Nov-Dec;19(6):972-9. , PMID:23807519.
  2. Hanks LJ, Casazza K, Ashraf AP, Ramanadham S, Ard J, Bray MS, Mark Beasley T, Fernandez JR. Vitamin D and calcium-sensing receptor polymorphisms differentially associate with resting energy expenditure in peripubertal children, J Bone Miner Metab. 2013 Nov;31(6):695-702 PMID: 23546818.
  3. Lynae J. Hanks, Ambika P. Ashraf, Barbara A. Gower, Jessica A. Alvarez, Krista Casazza. Subclinical indication of linkage between markers of skeletal and cardiovascular properties, Bone Research, 2013, 1(3): 291-297, PMID:23546818.
  4. Jason P. Skelley, BS, David R. Luthin, PhD, Jessica W. Skelley, PharmD, Edmond K. Kabagambe, DVM, PhD, Ambika P. Ashraf, MD, and Joycelyn A. Atchison, MDParental Perspectives of Diabetes Management in Alabama Public Schools, Southern Medical Journal ,April 2013 2013 Apr;106(4):274-9. PMID:23558417.
  1. Ambika P Ashraf, Gordon Fisher, Jessica Alvarez, Tanja Dudenbostel, David A. Calhoun, Alexander Szalai, Barbara A. Gower, Associations of C-Reactive Protein to Indices of Vascular Health and the Influence of Serum 25(OH)D Status in Healthy Adults, Journal of Nutrition and Metabolism, 2012;2012:475975, PMID: 23029606.
  2. Bhuvana Sunil, Alyssa Reddy, Nichole Bryant, Daniel W. Young, Ambika P. Ashraf, Invasive Giant Prolactinoma Presenting as a Nasal Polyp: Journal of Pediatrics, 2012 Sep 28, PMID:23026487.
  3. Anna Newton, Lynae J. Hanks, Ambika Ashraf, Elizabeth Williams, Michelle Davis and Krista Cassaza, Macronutrient intake influences the effect of 25-hydroxy-vitamin D status on metabolic syndrome outcomes in African American Girls, Cholesterol. 2012;2012:581432, PMID: 22792449.
  4. Jessica A. Alvarez, Barbara A. Gower, David A. Calhoun, Suzanne E. Judd, Yanbin Dong, Tanja Dudenbostel, Jenni Scholl, Ambika P. Ashraf, Serum 25-hydroxyvitamin D and Ethnic Differences in Arterial Stiffness and Endothelial Function, J Clin Med Res. 2012 Jun;4(3):197-205, PMID: 22719806.
  5. Lynae J. Hanks PhD, RD, Ambika Ashraf, MD, Jessica A. Alvarez, PhD, RD, T. Mark Beasley PhD, Jose R. Fernandez PhD, and Krista Casazza, PhD, RD; BMI, but Not Race Contributes to Vitamin D–Parathyroid Hormone Axis in Peripubertal Girls, ICAN: Infant, Child, & Adolescent Nutrition, 2012 Dec.
  6. LJ Hanks, K Casazza, A Ashraf, JR Fernandez, Calcium homeostasis may influence resting energy expenditure with effects most apparent in early pubertal girls, Acta Pædiatrica 2012 Aug;101(8):e363-8, PMID: 22587658.
  7. Hypercalcemic crisis induced by calcium carbonate, Ashutosh Singh and Ambika Ashraf, Clin Kidney J (2012) 5(4): 288–291.
  8. Lynae J. Hanks, Anna L. Newton, Ambika P. Ashraf, Orlando M. Gutierrez and Krista Casazza, Reduced-carbohydrate, weight loss diet is associated with greater bone mineral content in obese African-American girls, Journal of Diabetes Research & Clinical Metabolism, 2012.
  1. James Gardner, Ambika Ashraf, Zhiying You and Kenneth McCormick, Changes in plasma FGF23 in growth hormone deficient children during rhGH therapy. J Pediatr Endocr Met 2011;24(9-10):645–650 , PMID: 22145450.
  2. Ambika Ashraf, Timothy Beukelman, David Kelly, Valerie Pruneta-Deloche, Abhimanyu Garg, Unusual case of episodic marked hypertriglyceridemia and associated pancreatitis in a pediatric patient found to have lipoprotein lipase auto-antibodies and Sjogren syndrome, J Clin Endocrinol Metab. 2011 Aug;96(8):2325-9. PMID: 21593105.
  3. Ambika P. Ashraf, Jessica Alvarez, Carrie Huisingh, Krista Casazza, Barbara Gower, Higher insulin concentrations may be positively influence the bone mineral density in African American Adolescents, Br J Med Med Res. 2013 Oct;3(4):1050-1061. PMID: 25258705.
  4. Amanda D. Benaderet, Amy M. Burton, Roderick Clifton-Bligh, Ambika P. Ashraf, Primary Hyperparathyroidism with Low Intact PTH Levels in a 14 year old girl; J Clin Endocrinol Metab 96 (8), 2011 May 18, PMID: 21593105
  5. Ambika Ashraf, Jessica Alvarez, Barbara Gower, Karen Saenz, Kenneth McCormick “Associations of vitamin D and components of the metabolic syndrome in obese adolescent females”; Obesity 2011 Nov;19(11):2214-21 , PMID: 21546933.
  1. Jessica Alvarez, Ambika Ashraf, Gary Hunter, Barbara Gower, Serum 25-Hydroxyvitamin D and Parathyroid Hormone are Independent Determinants of Whole-Body Insulin Sensitivity in women and May Contribute to Lower Insulin Sensitivity among African Americans, The Am J of Clin Nutr 2010 Dec;92(6):1344-9, PMID:20861177.
  2. Ambika Ashraf, Nancy Beckman Eason, Edmond Kabagambe, Josna Haritha, Sreelatha Meleth, Kenneth McCormick,P PPotential role of dietary iron in the first 4 months of infancy and the development of type 1 diabetes,  Diabetol Metab Syndr. 2010 Sep 20;2(1):58 PMID:20854668.
  3. Jessica A. Alvarez MS, RD and Ambika Ashraf, MD, Role of Vitamin D in Glucose Homeostasis and Insulin Sensitivity, International Journal of Endocrinology 2010;2010:351385, PMID:20011094.
  4. Ambika Ashraf, Jessica Alvarez, Karen Saenz, Barbara Gower, Kenneth McCormick, Frank Franklin; Threshold for effects of vitamin D deficiency on glucose metabolism in obese female African American adolescents J Clin Endocrinol Metab. 2009 Sep;94(9):3200-6.
  5. Ambika Ashraf, Yufeng Li, Frank Franklin, Kenneth McCormick, Elaine Moreland, Racial disparities on glycemic control and lipid profiles in children with Type 1 Diabetes. Clinical Medicine: Endocrinology and Diabetes 2009: 2; 1-6.
  6. Romeo Fernandez MD, Ambika Ashraf MD, Leon Dure MD “Nutritional vitamin D deficiency presenting as hemi chorea” Journal of Child neurology, 2007 Jan; 22 (1): 74-76, PMID:17608310.
  7. Ambika Ashraf, Gail Mick, Sreelatha Meleth, Xudong Wang, Kenneth McCormick. Insulin treatment reduces pre-prandial plasma ghrelin concentrations in children with type 1 diabetes, Medical Science Monitor, 2007 Dec 1;13(12):CR533-537,  PMID:18049431.
  8. Ambika Ashraf, Gail Mick, Joycelyn Atchison, Bragan Petrey, Hussein Abdullatif, Kenneth McCormick. Prevalence of hypovitaminisus D in early infantile hypocalcemia. Journal of Pediatric Endocrinology and Metabolism, 2006 Aug;19(8):1025-31, PMID:16995588.
  9. Ambika Ashraf, Hussein Abdullatif, Daniel Young; Permanent exocrine and endocrine pancreatic deficiency following hemolytic uremic syndrome, The Journal of Pediatrics, 2006 July, 149(1):139, PMID:16860145.
  10. Hussein Abdullatif, Ambika Ashraf; Reversible hypothyroidism, Endocrine practice, 2006 Sep-Oct;12(5):572, PMID:17002934
  11. Ambika Ashraf MD, Amy Albert MD, Kenneth McCormick MD. ”Bronchiolitis with hyponatremia” Clinical pediatrics, 2006 Jan-Feb;45(1): 101-104, PMID:16429225
  12. Ambika Ashraf, Gail Mick, Sreelatha Meleth, Hussein Abdullatif, Xudong Wang, and Kenneth McCormick, Effect of insulin on plasma vascular endothelial growth factor in children with new onset diabetes. J. Clin. Endocrinol. Metab.2005 Aug;90(8): 4920-4923, PMID:15914522.
  13. Ambika Ashraf, Hussein Abdullatif, William Hardin, and J. Michael Moates, Unusual Case of Neonatal Diabetes Mellitus Due to Congenital Pancreas Agenesis, Pediatric Diabetes 2005 Dec; 6(4): 239-243, PMID:16390394
  14. Ambika Ashraf MD, Joycelin Atchison MD. The autoimmune poly glandular syndrome in the Index of Suspicion of “Pediatrics in Review," 2005 February;26(2):68, PMID: 15687477.
  15. Ambika Ashraf MD, Hussein Abdul-latif MD, William Hardin MD, David Kelly MD. “Vaginal bleeding and Galactorrhea in a child with ovarian steroid cell tumor” Endocrine Practice. 2005 September-October; 11 (No.5) 346-349, PMID:16191497.
  16. Ambika Ashraf MD, Kenneth McCormick MD. “Hyper reninemia and hypoaldosteronism in a child with short stature”; ‘The Endocrinologist’ 2004 December;14(6): 313-316
  17. Ambika Ashraf MD, Kenneth McCormick MD; The case of the child with hypoparathyroidism; in the Index of Suspicion in the Nursery in “Neo Reviews," August 2004, PMID:15687477.
  18. Ambika Ashraf, Teresa Magruder, H. AbdulLatif; Vitamin D- deficiency Rickets and septic arthritis of hip. ‘Resident and Staff physician’, 2004 June; 50(6):28-31.
  19. Anantha K Harijith, Parameswaran Hari, Kadakkal Radhakrishnan, Ambika Ashraf. A Serious Problem Deserving More Serious Attention. BMJ Electronic journal: 15 April 2002 (Letter).