You are here

Andrzej T. Slominski, MD, PhD

Andrzej T.  Slominski, MD, PhD Professor
Department of Dermatology
University of Alabama at Birmingham
VH 476C, Birmingham, AL 35294; VA Medical
Center, 700 South 19th Street, Birmingham, AL 35233
Phones: (205) 934-5245; VA: 205.933.8101 ext. 8625
Full CV


  • Graduate/Medical School
    Medical University of Gdansk, Poland (9/1973 6/1979) MD (with honors) 1979
    Medical University of Gdansk, Poland (5/1983) PhD
  • Clinical Fellowship
    Dermatopathology, Division of Dermatology and Dermatopathology, Albany Medical Center, Albany, NY (7/96-6/97)
  • Residency
    Anatomic Pathology, Department of Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY (7/1/93-6/30/96)
  • Internship
    Municipal Hospital, Tczew, Poland (9/1979-9/1980)
  • Postdoctoral Training
    Yale University School of Medicine, Postdoctoral Fellow, Department of Dermatology, New Haven, CT (1/10/85-4/30/89)

Research Interests:

As a physician-scientist trained by Aaron Lerner and John Pawelek in pigment biology and melanoma and by Martin Mihm in skin pathology, Dr. Slominski has a longstanding (>30 years) trajectory of research (skin, cellular and molecular biology, biochemistry, melanin pigmentation, cancer, photobiology and endocrinology) and clinical (dermatopathology and pathology) activities with 328 peer reviewed papers. His recent focus is on neuroendocrinology of the skin, cancer, photobiology, pigment biology, cutaneous steroidogenesis, vitamin D plus novel secosteroids and melatonin. His contribution to the International and Pan-American Pigment Cell and Melanoma communities is exemplified by service as secretary/treasurer (2008-2014) or council member (2007-2018) of the PASPCR, secretary of the International Federation of Societies for Pigment Cell Research (IFPCS) (2011-2014) and past membership (2006-2010) in the Steering Committee of the Society for Melanoma Research (SMR). His academic track record is marked by discoveries of cutaneous expression of classical hypothalamic and pituitary hormones, discoveries of cutaneous serotoninergic and melatoninergic systems, an defining the skin as a neuroendocrine organ. Most important is the discovery of new seco/steroidogenic pathways that includes non-classical activation of vitamin D and discovery of new lumisterogenic pathway.


  • 2019
  • 2018
  • 2017
  • 2016
  • 2015
  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • pre 2010
  1. Tuckey RC, Cheng CYS and Slominski  AT (2019). The serum vitamin D metabolome: What we know and what is still to discover. J Steroid Biochem Mol Biol 186, 4-21.
  2. Chaiprasongsuk A, Janjetovic Z, Kim TK, Jarrett SG, D'Orazio JA, Holick MF, Tang EKY, RC Tuckey RC, Panich U, Li W,  Slominski AT (2019)  Protective effects of novel derivatives of vitamin D3 and lumisterol against UVB-induced damage in human keratinocytes involve activation of Nrf2 and p53 defense mechanisms. Redox Biology 24, June 2019, 101206
  3. Markiewicz A, Brożyna AA, Podgórska E, Elas M, Urbańska K, Jetten AM, Słominski AT, Jóźwicki W, Orłowska-Heitzman J, Dyduch G, Romanowska-Dixon B (2019) Vitamin D receptors (VDR), hydroxylases CYP27B1 and CYP24A1 and retinoid-related orphan receptors (ROR) level in human uveal tract and ocular melanoma with different melanization levels. Sci Rep (2019) 9:9142 |
  4. Bocheva G, Slominski RM, Slominski AT (2019) Neuroendocrine aspects of skin aging. Int J Mol Sci. 2019 Jun 7;20(11). pii: E2798. doi: 10.3390/ijms20112798.
  5. 369. Manna PR, Ahmed AU, Yang S, Narasimhan M, Cohen-Tannoudji J, Slominski AT, Pruitt K (2019) Genomic profiling of the steroidogenic acute regulatory protein in cancer: in silico assessment and mechanistic perspective. Cancers (Basel). 2019 May 4;11(5). pii: E623. doi: 10.3390/cancers11050623.
  6. Culter-Peck CM, Dryden SC, Fowler BT, Kovacic D, Slominski A, Fleming JC (2019) Essential skin shrinkage: cicatricial ectropion, a histopathologic evaluation and clinical analysis. Orbit. 2019 May 20:1-5. doi: 10.1080/01676830.2019.1600152. [Epub ahead of print]
  7. Brozyna A, Jozwicki W, Jetten AM, Slominski A (2019) On the relationship between VDR, RORα and RORγ receptors expression and HIF1-α levels in human melanomas. Exp Dermatol, doi: 10.1111/exd.14002.
  8. Slominski RM, Tuckey RC, Mana P, Jetten A, Postlethwaite A, Raman C,  Slominski AT. Extra-adrenal glucocorticosteroidogenesis: Implications for autoimmune and inflammatory disorders. Genes & Immunity, in preparation, an invited review.
  1. Slominski AT, Brozyna AA, Skobowiat C, Zmijewski MA, Kim T-K, Janjetovic Z, Oak AS, Jozwicki W,   Jetten AM,   Mason RS, Elmets C, Li W,   Hoffman1RM,   Tuckey RC (2018) On the role of classical and novel forms of vitamin D in melanoma progression and management. J Steroid Biochem Mol Biol 177:159-170.
  2. Cheng CYS, Tae-Kang Kim , Saowanee Jeayeng , Slominski AT, Tuckey RC (2018) Purified CYP2R1 in a in a reconstituted membrane environment and its 25-hydroxylation of 20-hydroxyvitamin D3. J Steroid Biochem Mol Biol 177, 59-69.
  3. Slominski AT, Hardeland R, Zmijewski MA, Slominski RM, Reiter RJ, Paus R (2018) Melatonin: A cutaneous perspective on its production, metabolism and functions. J Invest Dermatol138:490-499.
  4. Lin Z,  Marepally SR, Goh SY, Cheng CYC, Janjetovic  Z, Kim TK, Miller DD, Postlethwaite AT, Slominski AT,  Tuckey RC,  Peluso-Iltis C, Rochel N,  Li W (2018)  Investigation of 20S-hydroxyvitamin D3 analogs and their 1α-OH derivatives as potent vitamin D receptor agonists with anti-inflammatory activities. Sci Rep. 2018 Jan 24;8(1):1478. doi: 10.1038/s41598-018-19183-7.
  5. Jetten MA, Takeda Y, Slominski A, Kang HS (2018) Retinoic acid-related Orphan Receptors (RORs): connecting sterol metabolism to regulation of immunity and disease. Current Opinion in Toxicology 8:66–80.
  6. Brożyna AA, Aplin A,  Cohen C, Carlson G, Page AJ, Murphy M, Slominski AT, Carlson JA (2018) CS1 expression in melanocytic nevi and melanoma. Oncotarget. 2018; 9:4173-4187.
  7. Tuckey RC, Li W, Ma D, Cheng CYS, Wang KM, Kim TK, Jeayeng S, Slominski AT (2018) CYP27A1 acts on the pre-vitamin D3 photoproduct, lumisterol, producing biologically active hydroxy-metabolites J Steroid Biochem Mol Biol 177, 59-69.
  8. Slominski AT, Zmijewski AM, Plonka P, Szaflarski J, Paus R (2018) How ultraviolet light touches the brain and endocrine system through skin, and why. Endocrinology 159(5), 1992-2007.
  9. Skobowiat C, Brozyna A, Janjetovic Z, Saowanee J, Oak, ASW, Kim TK, Panich U, Reiter RJ, Slominski AT (2018) Melatonin and its derivatives counteract the ultraviolet B radiation-induced damage in human and porcine skin ex vivo. J Pineal Res 65(2):e12501. doi: 10.1111/jpi.12501.
  10. Sniegocka M, Podgorska E, Plonka PM, Elas M, Romanowska-Dixon B, Szczygiel M, Zmijewski M, Cichorek M, Markiewicz A, Brozyna A, Slominski AT, Urbanska K (2018) Transplantable melanomas in hamsters and gerbils as models for human melanoma. Sensitization in melanoma radiotherapy: from animal models to clinical trials. Int J Mol Sci 19(4), 1048;
  11. Singh B, Schoeb TR, Baipi P Slominski AT, Singh KK (2018) Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function  Cell Death & Disease Jul 20;9(7):735.
  12. Podgorska E, Drzal A, Matuszak Z, Swakon J, Slominski AT, Elas M, Urbanska K (2018) Calcitriol and Calcidiol Can Sensitize Melanoma Cells to Low⁻LET Proton Beam Irradiation. Int J Mol Sci 2018 Jul 31;19(8). pii: E2236. doi: 10.3390/ijms19082236.
  13. Podgorska E, Sniegocka M, Mycinska M, Trybus W, Trybus E, Kopacz-Bednarska A, Wiechec O, Krzykawska-Serda M, Elas M, Krol T, Urbanska K,  Slominski AT  (2018) Acute hepatologic and nephrologic effects of calcitriol in Syrian golden hamster (Mesocricetus auratus). Acta Biochim Pol 65, 351-358.
  14. Wasiewicz T, Piotrowska A, Wierzbicka J, Slominski AT, Zmijewski MA (2018) Antiproliferative Activity of Non-Calcemic Vitamin D Analogs on Human Melanoma Lines in Relation to VDR and PDIA3 Receptors.  In J Mol Sci 2018, 19(9), 2583;
  15. Slominski A T, Kim TK, Janjetovic Z, Brozyna AA, Zmijewski MA, Xu H, Sutter TR, Tuckey RC, Jetten AM, Crossman DK (2018) Differential and Overlapping Effects of 20,23(OH)(2)D3 and 1,25(OH)(2)D3 on Gene Expression in Human Epidermal Keratinocytes: Identification of AhR as an Alternative Receptor for 20,23(OH)(2)D3. In J Mol Sci 2018, 19 (10), 3072;
  1. Plonka PM, Picardo M, Slominski AT. Does melanin matter in the dark? (2017) Exp Dermatol. 26:595–597,  2016. doi: 10.1111/exd.13171. PubMed PMID: 27541811
  2. Schlabritz-Loutsevitch N, Apostolakis-Kyrus K, Krutilina R, Hubbard G, Kocak M, Janjetovic Z, Sathanandam S, Slominski AT, Mari G, Dick E, Jr (2016) Pregnancy-driven cardiovascular maternal miR-29 plasticity in obesity. J Med Primatol 45, 297–303. PubMed PMID: 27627870.
  3. Slominski A, Zmijewski M, Jetten A (2016) RORα is not a receptor for melatonin (Response to DOI 10.1002/bies.201600018). BioEssays 38, 1193-1194.
  4. Skobowiat C, Postlethwaite AE, Slominski AT (2017). Skin Exposure to Ultraviolet B Rapidly Activates Systemic Neuroendocrine and Immunosuppressive Responses. Photochem Photobiol. 93:1008–1015,  2017. doi: 10.1111/php.12642. PubMed PMID: 27716949.
  5. Wierzbicka JM, Zmijewski MA, Antoniewicz J, Sobjanek M, Slominski AT (2017)  Differentiation of Keratinocytes Modulates Expression of Epidermal Elements of the Cutaneous Analog of Hypothalamus-Pituitary-Adrenal Axis. J Cell Physiol 232(1):154-166. doi: 10.1002/jcp.25400. PubMed PMID: 27061711.
  6. Slominski A, Zmijewski M (2017) Glucocorticoids Inhibit Wound Healing: Novel Mechanism of Action. J Invest Dermatol 137, 1012–1014.
  7. Jeayeng S, Wongkajornsilp A, Slominski AT, Jirawatnotai S, Sampattavanich S, Panich U (2017) Nrf2 in keratinocytes modulates UVB-induced DNA damage and apoptosis in melanocytes through MAPK signaling. Free Rad Biol Med 108, 918–928.
  8. Abyaneh, M.A.Y., Engel P, Slominski A., Rgasdale B., Agag R., Cramer D., Carlson J.A. (2017) Giant Basal Cell Carcinomas Express Neuroactive Mediators and Show a High Growth Rate: A Case-Control Study and Meta-Analysis of Etiopathogenic and Prognostic Factors. Amer J Dermatopathol 39:189–194.
  9. Janjetovic Z, Jarrett SG, Lee EF, Duprey C, Reiter RJ, Slominski AT. (2017) Melatonin and its metabolites protect human melanocytes against UVB-induced damage: Involvement of NRF2-mediated pathways. Sci Rep 2017;7(1):1274.
  10. Slominski A.T. , Brożyna AA, Zmijewski MA, Jóźwicki W, Jetten AM, Mason RS, Tuckey RC and Elmets CA (2017) Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management. Lab Invest 97, 706-724 (June 2017) | doi:10.1038/labinvest.2017.3
  11. Skobowiat C, Oak ASW, Kim T-K, Yang CH, Pfeffer LM, Tuckey RC, Slominski AT (2017) Noncalcemic 20-hydroxyvitamin D3 inhibits human melanoma growth in in vitro and in vivo models. Oncotarget 8:9823-9834.
  12. Brożyna AA , Guo H , Yang S-E , Cornelius L , Linette G , Murphy M , Sheehan C , Ross J , Slominski A , Carlson JA .TRPM1 (melastatin) expression is an independent predictor of overall survival in clinical AJCC stage I and II melanoma patients. J Cutan Pathol. 2017;44:328–337.
  13. Slominski AT, Zmijewski M, Semak I, Kim T-K, Janjetovic Z, Slominski RM, Zmijewski J (2017) Melatonin, mitochondria and the skin. Cell Mol Life Sci 74(21), 3913-3925.
  14. Slominski AT, Brozyna AA, Tuckey RC (2017) Cutaneous glucocorticoidogenesis and cortisol signaling are defective in psoriasis. J Invest Dermatol 137, 1609-1611.
  15. 349. Lin Z, Chen H, Belorusova A, Bollinger JC, Tang EKY, Janjetovic Z, Kim TK, Wu Z, Miller DD, Slominski AT, Postlethwaite A, Tuckey RC, Rochel N, Li W (2017) 1α,20S-Dihydroxyvitamin D3 Interacts with Vitamin D Receptor: Crystal Structure and Route of Chemical Synthesis. Sci Rep 7:10193; DOI:10.1038/s41598-017-10917-7
  16. Tarasen A, Carlson JA, Leonard MK, Merlino G, Kaetzel D, Slominski AT (2017) Pigmented Epithelioid Melanocytoma (PEM)/Animal Type Melanoma (ATM): Quest for an Origin. Report of One Unusual Case Indicating Follicular Origin and Another Arising in an Intradermal Nevus. In J Mol Sci 18, 1769; doi:10.3390/ijms18081769
  17. Leonard MK, Pamidimukkala N, Puts G, Snyder DE, Slominski AT, Kaetzel D (2017) The HGF/SF Mouse Model of UV-Induced Melanoma as an In Vivo Sensor for Metastasis-Regulating Gene. Int. J. Mol. Sci. 2017, 18, 1647; doi:10.3390/ijms18081647.
  18. Slominski AT, Kim TK, Hobrath JV, Janjetovic Z, Oak ASW, Postlethwaite A, Lin Z, Li W, Takeda Y, Jetten AM, Tuckey RC (2017) Characterization of a new pathway that activates lumisterol in vivo to biologically active hydroxylumisterols. Sci Rep2017; 7:11434
  1. Manna PR, Stetson CL, Slominski AT, Pruitt K (2016)  Role of the steroidogenic acute regulatory protein in health and disease. Endocrine 51: 7-21.
  2. Slominski AT, Kim TK, Li W, Tuckey RC (2016) Classical and non-classical metabolic transformation of vitamin D in dermal fibroblasts Exp Dermatol 25:231-232.
  3. Skobowiat C, Slominski A (2016)  Ultraviolet B stimulates POMC signaling in the arcuate nucleus of the hypothalamus in mice. Exp Dermatol 25:120-3.
  4. Schlabritz-Loutsevitch NE, Comuzzie AG, Mahaney MM, Hubbard GB, Dick EJ, Kocak M, Gupta S, Carrillo M, Schenone M, Postlethwaite A, Slominski A (2016). Serum Vitamin D Concentrations in Baboons (Papio spp.) during Pregnancy and Obesity. Comp Med. 66:137-42.
  5. Lin Z, Marepally SR, Kim TK, Janjetovic Z, Oak AS, Postlethwaite AE, Myers LK, Tuckey RC, Slominski AT, Miller DD, Li W (2016). Design, Synthesis and Biological Activities of Novel Gemini 20S-Hydroxyvitamin D3 Analogs. Anticancer Res. 2016;36(3):877-86. PubMed PMID: 26976974.
  6. Cheng CY, Slominski AT, Tuckey RC (2016) Hydroxylation of 20-hydroxyvitamin D3 by human CYP3A4. J Steroid Biochem Mol Biol. 159:131-41.
  7. Jozwicki W, Brozyna AA, Siekiera J, Slominski AT (2016) Changes in Immunogenicity during the Development of Urinary Bladder Cancer: A Preliminary Study. Int J Mol Sci. 2016;17(3) 285. doi: 10.3390/ijms17030285. PubMed PMID: 26927070; PMCID: PMC4813149.
  8. Jozwicki W, Brozyna AA, Siekiera J, Slominski AT (2016) Frequency of CD4+CD25+Foxp3+ cells in peripheral blood in relation to urinary bladder cancer malignancy indicators before and after surgical removal.
    Oncotarget 10, 11450-62. doi: 10.18632/oncotarget.7199. PubMed PMID: 26862849.
  9. Lin Z, Marepally SR, Ma D, Kim TK, Oak AS, Myers LK, Tuckey RC, Slominski AT, Miller DD, Li W (2016) Synthesis and Biological Evaluation of Vitamin D3 Metabolite 20S,23S-Dihydroxyvitamin D3 and Its 23R Epimer. J Med Chem. 59:5102-5108. doi: 10.1021/acs.jmedchem.6b00182. PubMed PMID: 27070779.
  10. Slominski AT, Semak I, Fischer TW, Kim TK, Kleszczynski K, Hardeland R, Reiter RJ (2017). Metabolism of melatonin in the skin: why is it important? Exp Dermatol 26:563–568,  doi: 10.1111/exd.13208. PubMed PMID: 27619234.
  11. Brozyna A, Jozwicki W, Roszkowski K, Filipiak J, Slominski AT (2016) Melanin content in melanoma metastases affects the outcome of radiotherapy. Oncotarget 20:17844-1785 2016 Feb 3. doi: 10.18632/oncotarget.7528. PubMed PMID: 26910282.
  12. Piotrowska A, Wierzbicka J, Ślebioda T, Woźniak M, Tuckey RC, Slominski AT, Żmijewski M A. (2016) Vitamin D derivatives enhance cytotoxic effects of H2O2 on human keratinocytes: Quest for improvement of anticancer drug activity. Steroids 110:49-61. doi: 10.1016/j.steroids.2016.04.002. PubMed PMID: 27083311; PMCID: PMC4853285.
  13. Skobowiat C, Slominski AT (2016) Sun-derived infrared A (IRA) and ultraviolet B (UVB) radiation: Allies or enemies in melanomagenesis? Exp Derm 25(10):760-762. doi: 10.1111/exd.13129. PubMed PMID: 27315042; PMCID: PMC5042839.
  14. Slominski AT, Kim TK, Hobrath JV, Oak AS, Tang EK, Tieu EW, Li W, Tuckey RC, Jetten AM. (2017) Endogenously produced nonclassical vitamin D hydroxy-metabolites act as "biased" agonists on VDR and inverse agonists on RORalpha and RORgamma. J Steroid Biochem Mol Biol. 173, 42-56. doi: 10.1016/j.jsbmb.2016.09.024. PubMed PMID: 27693422.
  15. Wierzbicka JM, Zmijewski MA, Piotrowska A, Nedoszytko B, Lange M, Tuckey RC, Slominski AT. (2016) Bioactive forms of vitamin D selectively stimulate the skin analog of the hypothalamus-pituitary-adrenal axis in human epidermal keratinocytes. Mol Cell Endocrinol. 437:312-322. doi: 10.1016/j.mce.2016.08.006. PubMed PMID: 27524410.
  16. Brozyna AA, Jozwicki W, Skobowiat C, Jetten A, Slominski AT (2016)  RORalpha and RORgamma expression inversely correlates with human melanoma progression. Oncotarget 20:17844-17853, 2016. doi: 10.18632/oncotarget.11211. PubMed PMID: 27542227.
  1. Kim TK, Lin Z, Tidwell W J, Li W, Slominski AT (2015) Melatonin and its metabolites accumulate in the human epidermis in vivo and inhibit proliferation and tyrosinase activity in epidermal melanocytes in vitro. Mol Cell Endocrinol 404, 1-8.
  2. Skobowiat C, Slominski A (2015) Ultraviolet B (UVB) activates hypothalamic-pituitary-adrenal (HPA) axis in C57BL/6 mice. J Invest Dermatol, 2015;135:1638-48.
  3. Slominski A (2015) On the role of endogenous opioid system in the regulation of epidermal homeostasis. J Invest Dermatol 135:333-4.
  4. Brozyna AA, Jozwicki W, Jochymski C, Slominski AT  (2015). Decreased expression of CYP27B1 correlates with the increased aggressiveness of ovarian carcinomas. Oncol Rep 33:599-606
  5. Slominski A, Haderland R, Reiter R (2015)  When the circadian clock meets the melanin pigmentary system. J Investigative Dermatol 135(4):943-5
  6. Slominski A, Postlethwaite A (2015). Skin under the sun: when melanin pigment meets vitamin D. Endocrinology 156: 1-4.
  7. Slominski RM, Zmijewski M, Slominski A (2015)  On the role of melanin pigment in melanoma. Exp  Dermatol 24: 258-259.
  8. Slominski AT, Li W, Kim T, Semak I, Wang J, Zjawiony J, Tuckey RC (2015) Novel activities of CYP11A1 and their potential physiological significance. J Steroid Biochem Mol Biol 151,25-37.
  9. Slominski A (2015) Ultraviolet radiation (UVR) activates central neuro-endocrine-immune system.  Photodermatology, Photoimmunology & Photomedicine 31:121-123
  10. Slominski AT, Janjetovic Z, Kim T-K, Wasilewski P, Rossa S, Hanna S, Sayre RM, Dowdy JC, Li W, Tuckey RC (2015) Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation. J Steroid Biochem Mol Biol 148: 52-60.
  11. Jozwicki W, Brozyna AA, Siekiera J, Slominski AT (2015) Expression of RCAS1 Correlates with Urothelial Bladder Cancer Malignancy. Int J Mol Sci 16, 3783-3803.
  12. Kim TK, Lin Z, J, Li W, Reiter RJ,  Slominski AT (2015) N1-acetyl-5-methoxykynuramine (AMK) is produced in the human epidermis and shows anti-proliferative effects. Endocrinology 156: 1630–1636.
  13. Slominski AT, Manna PR, Tuckey RC (2015) On the role of skin in the regulation of local and systemic steroidogenic activities. Steroids 103, 72-78.
  14. Wasiewicz T, Szyszka P, Cichoreck M, Janjetovic Z, Tuckey RC, Slominski A, Zmijewski M (2015) Antitumor effects of vitamin D analogs on hamster and mouse melanoma cell lines in relation to melanin pigmentation. In J Mol Sci 24;16:6645-67.
  15. Slominski AT, Brozyna A, Jozwicki W, Tuckey RC (2015) Vitamin D as an adjuvant in melanoma therapy. Melanoma Manag. 2:1-4.
  16. Zabul P, Wozniak M, Slominski AT, Preis K, Gorska M, Korozan M, Wieruszewski J, Zmijewski MA, Zabul E, Tuckey R, Kuban-Jankowska A, Mickiewicz W, Knap N (2015)  A Proposed Molecular Mechanism of High-Dose Vitamin D3 Supplementation in Prevention and Treatment of Preeclampsia. Int J Mol Sci.  16:13043-64
  17. Manna PR, Sennoune SR, Martinez-Zaguilan R, Slominski AT, Pruitt K (2015) Regulation of retinoid mediated cholesterol efflux involves liver X receptor activation in mouse macrophages. Biochem Biophys Res Commun.  464:312-7.
  18. Wierzbicka JM, Binek A, Ahrends T, Nowacka JD, Szydłowska A, Turczyk Ł, Wąsiewicz T, Wierzbicki PM, Sądej R, Tuckey RC, Slominski AT, Chybicki J, Adrych K, Kmieć Z, Żmijewski MA (2015) Differential antitumor effects of vitamin D analogues on colorectal carcinoma in culture. Int J Oncol. 4:1084-96.
  19. Manna PR, Stetson CL, Daugherty C, Shimizu I, Syapin PJ, Garrel G, Cohen-Tannoudji J, Huhtaniemi I, Slominski AT, Pruitt K, Stocco DM (2015)  Up-regulation of steroid biosynthesis by retinoid signaling: Implications for aging. Mech Ageing Dev 150: 74-82.
  20. Tieu EW, Li W, Chen J, Kim TK, Ma D, Slominski AT, Tuckey RC (2015) Metabolism of 20-hydroxyvitamin D3 and 20,23-dihydroxyvitamin D3 by rat and human CYP24A1. J Steroid Biochem Mol Biol. 149:153-65.
  21. Lin Z, Marepally S,  Ma D,  Myers L,  Postlthwaite A, Tuckey RC, ChengC, Kim TK Yue J, Slominski A, Miller D, Li W (2015) Chemical synthesis and biological activities of 20S,24S/R-dihydroxyvitamin D3 epimers and their 1α-hydroxyl derivatives. J Med Chem 58:7881-7887.
  22. Slominski AT,  Kim TK, Li W, Postlethwaite A, Thieu EW, Thang EKY, Tuckey RC (2015) Detection of novel CYP11A1-derived secosteroids in the human epidermis and serum and pig adrenal gland. Sci. Rep. 5, 14875; doi: 10.1038/srep14875 (2015).
  23. Jozwicki W, Brozyna A, Siekiera J, Slominski AT (2015) Expression of Vitamin D Receptor (VDR) Positively Correlates with Survival of Urothelial Bladder Cancer Patients. Int J Mol Sci 16:24369-86.
  24. Wang Q, Lin Z, Kim TK, Slominski AT, Milled DD, Li W (2015) Total synthesis of biologically active 20S-hydroxyvitamin D3. Steroids 104:153-62.
  25. Slominski AT, Kim TK, Li W, Tuckey RC (2015) Classical and non-classical metabolic transformation of vitamin D in dermal fibroblasts Exp Dermatol 25:231-232.
  1. Slominski A, Zmijewski M, Zbytek B, Pisarchik A, Li W, Zjawiony J, Tuckey RC (2014) Cytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways. Anticancer Agents Med Chem 14, 77-98; PMCID: PMC3740756
  2. Brozyna, Jochymski C, Janjetovic Z, Jozwicki W, Tuckey RC, Slominski A (2014) CYP24A1 Expression Inversely Correlates with Melanoma Progression: Clinic-Pathological Studies. Int J Mol Sci 15, 19000-19017.
  3. Slominski A, Kim TK, Li W, Yi AK, Postlethwaite A, Tuckey RC (2014) The physiological role of CYP11A1 in vitamin D regulation of epidermal functions. J Steroid Biochem Mol Biol 144PA, 28-39.
  4. Zhu G, Janjetovic Z, Slominski A (2014) On the role of environmental humidity on cortisol production by epidermal keratinocytes . Exp Dermatol 23, 15-17.
  5. Manna PR, Slominski AT, King SR, Stetson CL, Stocco DM (2014) Synergistic activation of steroidogenic acute regulatory protein expression and steroid biosynthesis by retinoids: involvement of cAMP/PKA signaling.  Endocrinology 155, 576-591.
  6. B. Brocato, A.A. Zoerner, Z. Janjetovic, C. Skobowiat, S. Gupta, B.M. Moore II, A. Slominski, J. Zhang, M. Schenone, R. Phinehas, R.J. Ferry Jr., E. Dick Jr., G.B. Hubbard, G. Mari, N. Schlabritz-Loutsevitch (2013)  Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity. Placenta 34:983-989
  7. Slominski, A.T., Kim, T-K., Shehabi, H.S., Tang, E., Benson, H.A.E., Semak, I., Lin, Z., Yates, C.R., Wang, J., Li, W., Tuckey, R.C. (2014)  In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes, Caco-2 colon cells and the adrenal gland. Mol Cellular Endocrinol 383, 181-192.
  8. Slominski, A. T. and A. J. Carlson (2014). Melanoma resistance: bright future for academicians and challenge for patient advocates.  Mayo Clin Proc 89, 429-433
  9. Slominski, A. , K. T-K, Y. Takeda, Z. Janjetovic, A. Brozyna, C. Skobowiate, J. Wang, A. Postlethwite, W. Li, R. Tuckey and A. Jetten (2014). RORα and ROR γ are expressed in human skin and serve as receptors for endogenously produced noncalcemic 20-hydroxy- and 20,23-dihydroxy-vitamin D. FASEB J 28:2775-2789.
  10. Chen, J., J. Wang, T. Kim, E. Tieu, E. Tamg, Lin Z, D. Kovacic, D. Miller, A. Postlethwaite, R. Tuckey, A. Slominski and W. Li (2014). Novel Vitamin D Analogs as Potential Therapeutics: The Metabolism, Toxicity Profiling, and Antiproliferative Activity. Anticancer Res 34: 2153-2163.
  11. Janjetovic Z, Nahmias ZP, Hanna S, Jarrett SG, Kim TK, Reiter RJ, Slominski AT (2014) Melatonin and its metabolites ameliorate UVB-induced damages in human epidermal keratinocytes. J Pineal Res 57, 90-102.
  12. Mari, G., Deprest, J., Schenone, M., Jackson, S., Samson, J., Brocato, B., Tate, D., Sullivan, R., White, G., Dhanireddy, R., Mandrell, T., Gupta, S., Skobowjat, C., Slominski, A., Cohen, H. L., Schlabritz-Loutsevitch, N. (2014) A novel translational model of percutaneous fetoscopic endoluminal tracheal occlusion - baboons (Papio spp.). Fetal Diagn Ther 35, 92-100.
  13. Brożyna AA, Jóźwicki W and Slominski AT (2014) Decreased VDR Expression in Cutaneous Melanomas as Marker of Tumor Progression: New Data and Analyses. Anticancer Res 34, 2735-2743.
  14. Slominski A, Manna RP, Tuckey RC (2014) Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the  skin integrity. Exp Derm 23, 369-374.
  15. Muenyi CS, Carrion S,  Jones LA, Kennedy LH, Slominski AT, Sutter CH, Sutter TR (2014) Effects of in Utero Exposure of C57BL/6J Mice to 2,3,7,8- Tetrachlorodibenzo-p-dioxin on Epidermal Permeability Barrier Development and Function. Environ Health Perspect 122: 1052-1058
  16. Slominski A, Kim TK, Brozyna AA, Janjetovic Z, Brooks DL, Schwab LP, Skobowiat C, Jozwicki W, Seagroves TN (2014) The role of melanogenesis in regulation of melanoma behavior: Melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways. Arch Biochem Biophys 563:79-93.
  17. Cheng CYS, Slominski AT, Tuckey RC (2014) Metabolism of 20-hydroxyvitamin D3 by mouse liver microsomes. J Steroid Biochem Mol Biol 144, 286-293.
  18. Tuckey RC, Slominski AT, Cheng CYS, Chen J, Kim TK, Xiao M, Li W (2014) Lumisterol is metabolized by CYP11A1: Discovery of a new pathway.  Int J Biochem Cell Biol 55, 24-34
  19. Slominski A, Kleszczynski K, Semak I, Janjetovic Z, Zmijewski MA, Kim TK, Slominski RM, Reiter RJ, Fischer TW (2014) Local melatoninergic system as the protector of skin integrity. Int J Mol Sci 15, 17705-17732.
  20. Brozyna, Jochymski C, Janjetovic Z, Jozwicki W, Tuckey RC, Slominski A (2014) CYP24A1 Expression Inversely Correlates with Melanoma Progression: Clinic-Pathological Studies. Int J Mol Sci 15, 19000-19017.
  1. Brozyna A, Jozwicki W, Janjetovic Z,  Slominski AT (2013) Expression of vitamin D activating enzyme 1-alpha-hydroxylase (CYP27B1) decreases during melanoma progression. Human Pathol 44, 374-387
  2. Jarrett SG, Novak M, Harris N, Merlino G, Slominski A, and Kaetzel DM (2013) NM23 deficiency promotes metastasis in a UV radiation-induced mouse model of human melanoma. Clin Exp Met 30, 25-36.
  3. Zbytek B, Peackock DL, Seagrove TN, Slominski A (2013) Putative role of HIF transcriptional activity in melanocytes and melanoma biology. Dermato-Endocrinology 4, 1-13.
  4. Slominski A, Zbytek B, Nikolakis G, Manna P, Skobowiat C, Zmijewski M, Li W, Janjetovic Z, Postlethwaite A, Zouboulis CC, Tuckey RC (2013) Steroidogenesis in the skin: implications for local immune functions. J Steroid Biochem Mol Biol 137, 107-123
  5. Tang EKY, Chen J, Janjetovic Z, Tieu EW,  Slominski AT, Li W, Tuckey, RC (2013) Hydroxylation of CYP11A1-derived products of vitamin D3 metabolism by human and mouse CYP27B1. Drug Metab Dispos 41(5):1112-1124 (
  6. Slominski A, Janjetovic Z, Tuckey RC, Nguyen MN, Bhattacharya KG, Wang J, Li W, Jiao Y, Gu W, Brown M, Postlethwaite AE (2013) 20-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits potent antifibrogenic activity in vivo. J Clin Endocrinol Metab  98, E298-E303.
  7. Zmijewski M, Slominski A (2013) Is Mc1r an important regulator of non-pigmentary  responses to UV radiation? Exp Derm 22, 790-791.
  8. Slominski A, Kim T-K, Zmijewski M, Janjetovic Z, Li W, Chen JJ, Kusniatsova EI, Semak I, Postlethwaite A, Miller D, Zjawiony J, Tuckey RC (2013) Novel vitamin D photoproducts and their precursors in the skin. Dermato-Endocrinology 5:1, 7-19.
  9. Kleszczynski K, Slominski A (2013) Targeting ALDH1A1 to treat pigmentary disorders. Exp Derm 22, 316-317.
  10. Chen JJ, Slominski A, Miller D, Li W (2013) Effects of side chain length and composition on the kinetic conversion and product distribution of vitamin D analogs determined by real-time NMR Dermato-Endocrinology, 5, 142-149.
  11. Skobowiat C. Sayre R, Dowdy J, Slominski A (2013). Ultraviolet radiation regulates cortisol activity in a waveband dependent manner in human skin ex-vivo. Brit J Dermatol 168, 595-601
  12. Kovacic, D, Carlson AJ, Slominski A (2013) Targeted chemotherapy of metastatic melanoma: the impact of tumor cell heterogeneity. Expert Rev Dermatol 8, No. 2 , Pages 131-134 (doi: 10.1586/edm.13.3)
  13. Kim TK, Kleszczynski, Janjetovic Z, Sweatman T, Lin Z, Li W, Reiter  R, Fischer T, Slominski AT (2013) Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells. FASEB J 27, 2742–2755: doi: 10.1096/fj.12-224691
  14. Brożyna AA, Jóźwicki W, Carlson JA, Slominski AT (2013) Melanogenesis affects overall and disease-free survival in patients with stage III and IV melanoma. Human Pathol 44, 2071-2074.
  15. Slominski A, Zmijewski M, Zbytek B, Tobin D, Tobin DJ, Theoharides TC, Rivier J. (2013) Key Role of CRF in the Skin Stress Response System. Endocrine Rev 34:827-884. 
  16. Nejati R, Skobowiat C, Slominski A (2013) Commentary on the practical guide for the study of sebaceous glands. Exp Dermatol 22, 629-630.
  17. Skobowiat C, Nejati R, Lu L, Williams R, Slominski A (2013) Genetic variation of the cutaneous HPA axis: An analysis of UVB-induced differential responses. Gene 530, 1-7.
  18. Nejati R, Kovacic D, Slominski A (2013) Neuro-immune-endocrine functions of the skin: an overview Expert Rev Dermatol 8(6), 581-583.
  1. Slominski A, Zmijewski, M, Pawelek J (2012) L-tyrosine and L-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions. Pigment Cell Melanoma Res  25, 14-27
  2. Sharpley CF,  McFarlane JR, Slominski A (2012) Stress-Linked Cortisol Concentrations in Hair: What We Know and What We Need to Know? Rev Neurosci 23, 111–121
  3. Tuckey RC,  Nguyen MN, Chen J, Slominski A, Baldisseri DM, Tieu EW, Li W (2012) Human cytochrome P450scc (CYP11A1) catalyses epoxide formation with ergosterol. Drug Metab  Dispos 40, 436-444.
  4. Tieu EW,  Li W,  Chen J,  Baldisseri DM, Slominski AT, Tuckey RC (2012) Metabolism of cholesterol, vitamin D3 and 20-hydroxyvitamin D3 incorporated into phospholipid vesicles by human CYP27A1. J Steroid Biochem Mol Biol 129, 163– 171.
  5. Slominski RM, Reiter RJ, Schlabritz-Loutsevitch  N, Ostrom RS, Slominski AT (2012). Melatonin membrane receptors in peripheral tissues: Distribution and functions. Mol Cell Endocrinol 351:152-66
  6. Lu Y, Chen J, Janjetovic J, Michaels P, Tang K Y, Wang J, Tuckey RC, Slominski AT, Li W, Miller DD (2012) Design, Synthesis and Biological Action of 20R-Hydroxyvitamin D. J Med Chem 55: 3573-3577
  7. Wang J, Slominski AT, Tuckey RC, Janjetovic Z, Kulkarni A, Chen J, Postlethwaite A, Miller D, Li W (2012) 20-Hydroxylvitamin D3 possesses high efficacy against proliferation of cancer cells while being non-toxic. Anticancer Res 32: 739-746
  8. Kim T-K,  Wang J,   Janjetovic Z,   Chen J,  Robert C. Tuckey RC, Nguyen MN,   Tang EKY,  Miller D, Li W, Slominski A (2012) Correlation between secosteroid induced vitamin D receptor activity in melanoma cells and computer-modeled receptor binding strength. Mol Cell Endocrinol 361: 143-152
  9. Slominski A, Zmijewski MA, Skobowiat C, Zbytek B, Slominski RM, and Steketee JD (2012). Sensing the environment: Regulation of local and global homeostasis by the skin  neuroendocrine system. Adv Anat, Embryol Cell Biol 212: 1-115.
  10. Bohm M, Zmijewski MA, Wasiewicz T, Straub RT, Raap U,  LugerTA, Slominski A (2012) KU812 basophils express urocortin, CRH-R, MC1R and steroidogenic enzymes and secrete progesterone. Exp Derm 21, 535–561
  11. Slominski, A. T., Kim, T.-K., Shehabi, H. Z., Semak, I., Tang, E. K. Y., Nguyen, M. N., Benson, H. A. E. Korik, E., Janjetovic, Z., Chen, J., Yates, C. R., Postlethwaite, A., Li, W. & Tuckey, R. C. (2012). In vivo evidence for a novel pathway of vitamin D3 metabolism initiated by P450scc and modified by CYP27B1. FASEB J 26, 3901–3915.
  12. Slominski, A. T., Kim, T.-K., Chen J.J., Nguyen, M. N., Li W., Yates, C. R., Sweatman, T, Janjetovic, Z., Tuckey, R. C.  (2012) Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in  placenta and epidermal keratinocytes. Int J Biochem Cell Biol 44, 2003– 2018.
  13. Szyszka P, Zmijewski MA, Slominski AT (2012) New vitamin D analogs as potential therapeutics in melanoma. Expert Rev  Anticancer Ther 12, 585–599.
  14. Slominski A, Janjetovic Z, Kim TK, Wright AC, Greese LN, Riney SJ, Nguyen MN, and Tuckey R (2012)  Novel vitamin D hydroxyderivatives inhibit melanoma growth and show differential effects on normal melanocytes. Anticancer Res  32, 3733-3742.
  15. Jarrett SG, Novak M, Dabernat S, Daniel JY, Mellon I, Zhang Q, Harris N, Ciesielski MJ, Fenstermaker RA, Kovacic D, Slominski A, and Kaetzel DM(2012) Metastasis suppressor NM23-H1 promotes repair of UV-induced DNA damage and suppresses UV-induced melanomagenesis. Cancer Res 72: 133-143.
  16. Guo H, Carlson AJ, Slominski A (2012) Role of TRPM in melanocytes and melanoma. Exp Dermatol 21, 650-654
  1. Zmijewski MA, Li W, Chen Jianjun, Kim Tae-Kang, Zjawiony JK, Sweatman TW, Miller DD, Slominski AT (2011) Synthesis and photochemical transformation of 3b,21-dihydroxypregna-5,7-dien-20-one to novel secosteroids that show anti-melanoma activity. Steroids 76, 193–203.
  2. Slominski A, Zmijewski MA, Zbytek B, Brozyna A, Granese J, Pisarchik A, Szczesniewski A, Tobin DJ (2011) Regulated proenkephalin expression in human skin and cultured skin cells. J Invest Dermatol 131: 613-622
  3. Slominski AT, Kim T-K., Janjetovic Z, Tuckey RC, Bieniek, R, Yue Y, Li W, Chen J, Miller D, Chen T, Holick M (2011) 20-hydroxyvitamin D2 is a non-calcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells. Am J Physiol: Cell Physiol 300:C526-C541.
  4. Brozyna A, Jozwicki W, Janjetovic Z,  Slominski AT (2011) Expression of vitamin D receptor (VDR) decreases during progression of pigmented skin lesions. Human Pathology42, 618–631
  5. Slominski AT, Li W, Bhattacharya SK, Smith RA, Johnson PL, Chen J, Nelson KE, Tuckey RC, Miller D, Jiao Y, Gu W,  .Postlethwaite A (2011) Vitamin D analogs 17,20S(OH)2pD and 17,20R(OH)2pD are noncalcemic and exhibit antifibrotic activity. J Invest Dermatol 131, 1167-1169
  6. Li L, Slominski A, Qian J, Carlson JA. (2011) Acquired primary cutaneous ganglioneuroma with adipocytic metaplasia: "An end point of melanocytic 'maturation'?" a case report and meta-analysis with comparison to a cross-sectional study of neurotized melanocytic nevi. Am J Dermatopathol. 33, 17-26.
  7. Linos K, Slominski A, Ross J, and  Carlson JA (2011).  Melanoma update: diagnostic and prognosticate factors that can effectively shape and personalize management. Biomarkers Med, 5 (3), 333–360.
  8. Tuckey RC,  Li W, Shehabi HZ, Janjetovic Z, Nguyen MN, Kim T-K, Chen J,. Howell DE, Benson HAE, Sweatman T, Baldisseri DM, Slominski A. Production of 22-hydroxy-metabolites of vitamin D3 by cytochrome P450scc (CYP11A1) and analysis of their biological activities on skin cells. Drug Metab  Dispos 39, 1577–1588.
  9. Skobowiat C, Dowdy JD, Sayre RM, Tuckey RC,  Slominski A (2011). Cutaneous hypothalamic pituitary adrenal (HPA) axis homologue -  Regulation by ultraviolet radiation. Amer J Physiol Endocrinol Metab 301:E484-E493.
  10. Vessels C, Patel TS, Greenhaw B, Shimek C, Randall MB, Slominski A, Skinner RB (2011)  Scalp nodule in a middle aged female.  Clin Exp  Dermatol 36, 818-819.
  11. Janjetovic Z, Brozyna A, Tuckey RC, Kim T-K, Nguyen, MN, Jozwicki W. Pfeffer SR, Pfeffer LM, Slominski AT (2011) High basal NF-kB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives. Brit J Cancer 105, 1874 – 1884.
  1. Lu S,  Slominski A,  Yang SE, Sheehan C, Ross J, Carlson JA,  (2010) The correlation of TRPM1 (Melastatin) mRNA expression with microphthalmia associated transcription factor (MITF) and other melanogenesis related proteins in normal and pathological skin,  hair follicles, and melanocytic nevi. J Cut Pathol, 37 (Suppl. 1): 26–40.
  2. Janjentovic Z, Tuckey RT, Nguyen MN, Thorpe E, Slominski A (2010) 20,23-Dihydroxyvitamin D3, Novel P450scc product, stimulates differentiation and inhibits proliferation and NF-κB  activity in human keratinocytes. J Cell Physiol 223, 36-48.
  3. Zmijewski M, Slominski A (2009) Modulation of CRF signaling through receptor splicing in mouse pituitary cell line AtT-20 - Emerging role of soluble isoforms. J Physiol Pharmacol 60, Suppl 4, 39-46
  4. Hang CH, Fan M, Slominski A, Yue J, Pfeffer L (2010) The role of constitutively activated STAT3 in B16 melanoma. Inter J Interferon, Cytokine Mediator Res 2,1-7.
  5. Kim T-K., Chen J., Li W., Zjawiony J., Miller D., Janjetovic Z., Tuckey R.C., Slominski A. (2010) A new steroidal 5,7-diene derivative, 3β-hydroxyandrosta-5,7-diene-17β-carboxylic acid, shows potent anti-proliferative activity. Steroids 75, 230-239
  6. Zmijewski M, Slominski A (2010) Emerging role of alternative splicing of CRF1 receptor in CRF signaling . Acta Biochim Pol 57, 1-13, 2010.
  7. Slominski AT, Janjetovic Z, Fuller BE, Zmijewski MA, Tuckey RC, et al. (2010) Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity. PLoS ONE 5(3): e9907.
  8. Li W, Chen J,  Janjetovic Z, Kim T-K., Sweatman T,  Zjawiony  J, Tuckey R.C., Miller, D.,  Slominski A.(2010) Chemical synthesis of 20S-hydroxyvitamin D3, which shows anti-proliferative activity. Steroids 75:926-35.
  9. Tang EKY, Li W,   Janjetovic Z,   Nguyen MN,  Wang Z, Slominski A, Tuckey RC (2010) Purified mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3 producing 1α,20,23-trihydroxyvitamin D3 which has altered biological activity. Drug Metab  Dispos 38: 1553-1559.
  10. Seiberg M, Lin CB, Hu Y, Rossetti D, Chen N, Cassarino D,  Slominski A (2010) Immuno-histochemical evaluation of solar lentigines: the association of KGF/KGFR and other factors with lesion development. J Dermatol Sci 59:91-97.
  11. Pinczewski J, Slominski A (2010)  The potential role of vitamin D in the progression of benign and malignant melanocytic neoplasms. Exp Dermatol 19, 860-864.
  12. Rech A, Wojcik-Maciejewicz A, Slominski AT (2010) Stress and the skin. Giornale Italiano di Dermatologia e Venereologia 145,213-220
  13. Slominski A (2010) Nicotinic receptor signaling in non-excitable epithelial cells: paradigm shifting from ion current to kinase cascade. Am J Physiol: Cell Physiol, (August 25, 2010). doi:10.1152/ajpcell.00324.2010


  1. Janjentovic Z, Zmijewski M, Tuckey RT, DeLeon DA, Nguyen MN, Pfeffer L, Slominski A (2009) 20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kB activity by increasing IkBa levels in human keratinocytes. PLoSOne 4(6), e5988.
  2. Schwartz AL, Malgor R, Dickerson E, Weeraratna AT, Slominski A, Wortsman J, Harii N, Kohn AD, Moon RT, Schwartz FL, Goetz DJ, Kohn LD, McCall KD (2009) Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration. Clin Cancer Res 15:4114-4122.
  3. P. M. Plonka, T. Passeron, M. Brenner, D. J. Tobin, S. Shibahara, A. Thomas, A. Slominski, A. L. Kadekaro, D. Hershkovitz, E. Peters, J. J. Nordlund, Z. Abdel-Malek, K. Takeda, R. Paus, J. P. Ortonne, V. J. Hearing, K. U. Schallreuter (2009) What are melanocytes really doing all day long…? Exp Dermatol 18, 799-819
  4. Slominski A, Zbytek B, Slominski R (2009) Inhibitors of melanogenesis increase toxicity of cyclophosphamide and lymphocytes against melanoma cells. Int J Cancer 124, 1470-1477.
  5. Slominski A (2009) On a role of the CRF signaling system in the etiology of inflammatory skin disorders. Brit J Dermatol 160:229–232
  6. Zmijewski MA, Li W, Zjawiony JK, Sweatman TW, Chen J, Miller DD, Slominski AT (2009) Photo-conversion of two epimers (20R and 20S) of pregna-5,7-diene-3β,17α,20-triol and their bioactivity in melanoma cells. Steroids 74, 218-228.
  7. Slominski A, Zmijewski MA, Semak I,  Sweatman T, Janjetovic Z, Li W, Zjawiony JK,  Tuckey RC (2009)  Sequential metabolism of 7-dehydrocholesterol to steroidal 5,7-dienes in adrenal glands and its biological implication in the skin. PLoSONE 4(2), e4309-e.
  8. Li W, Slominski, R, Slominski A  (2009) HRMAS NMR analysis of metabolic changes in melanoma cells after induction of melanogenesis. Anal Biochem 386:282-284
  9. Zmijewski M, Slominski A (2009) CRF1 receptor splicing in epidermal keratinocytes: Potential biological role and environmental regulations. J Cell Physiol 218: 593–602.
  10. Nguyen MN, Slominski A, Li W, Ng WR, Tuckey RC . (2009) Metabolism of vitamin D2 to 17,20,24-trihydroxyvitamin D2 by cytochrome P450scc (CYP11A1). Drug Metab  Dispos. 37:761–767
  11. Slominski A (2009) Neuroendocrine activity of the melanocyte. Exp Dermatol, 18: 760-763
  12. Zmijewski M, Sweatman T,  Slominski A (2009) The melatonin-producing system is fully functional in retinal pigment epithelium (ARPE-19). Mol Cell Endocrinol 307:211-216.
  13.  Slominski A (2009) Are suberythemal doses of ultraviolet B good for your skin?   Pigment Cell Melanoma Res 22, 154-155
  14. Carlson JA, Ross J, Slominski A (2009)  New techniques in dermatopathology that help to diagnose and prognosticate melanoma. Clin Dermatol 27, 75-102


  1. Nordlind K, EC Azmitia, Slominski A (2008) The skin as a mirror of the soul: Exploring the possible roles of serotonin. Exp Dermatol 17, 301-311.
  2. Tuckey RC, Janjetovic,Z, Li W, Nguyen MN, Zmijewski MA,  Zjawiony JK, Slominski A. (2008) Metabolism of 1a-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1a,20-dihydroxyvitamin D3. J Steroid Biochem Mol Biol, 112(4-5):213-9
  3. Fischer T, Zmijewski M, Zbytek B, Wortsman J,  Slominski A (2008) Melatonin maintains mitochondrial membrane potential and attenuates activation of initiator (casp-8/casp-9) and effector caspases (casp-3/casp7) and PARP in UVR-exposed keratinocytes. J Pineal Res 44, 397–407.
  4. Fischer T, Slominski A, Tobin DJ, Paus R (2008) Melatonin and the hair follicle. J Pineal Res 44, 1-15.
  5. Slominski A, Tobin DJ, Zmijewski M, Wortsman J, Paus R (2008)  Cutaneous melatonin: production, metabolism and phenotypic effects. Trends Endo Metab  19, 17-24.
  6. Schallreuter K.U., Bahadoran P., Picardo M., Slominski A., Elassiuty Y.E., Kemp E.H., Giachino C., Liu J.B., Luiten R.M., Lambe T., Le Poole I.C., Dammak I., Onay H., Zmijewski M.A., Dell’Anna M.L., Zeegers M.P., Cornall R.J., Paus R., Ortonne J.P.,  Westerhof W. (2008) Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else? Exp Derm 17, 139-160
  7. Slominski A, Wortsman J, Paus, R, Elias PM, Tobin DJ, Feingold K (2008) Skin  as an endocrine organ: implications for its function. Drug Discovery Today: Dis Mech 5: e137-e144
  8. Fischer T, Slominski A, Zmijewski M, Reiter RJ, Paus R (2008) Melatonin as a major skin protectant: From free radical scavenging to DNA damage repair. Exp Derm 17: 713-730.
  9. Zbytek B, Janjetovic Z, Tuckey RC, Zmijewski MA, Sweatman TW, Jones E, Nguyen MN, Slominski AT. (2008)  20-Hydroxyvitamin D3, a Product of Vitamin D3 Hydroxylation by Cytochrome P450scc, Stimulates Keratinocyte Differentiation. J Invest Dermatol 128, 2271-2280.
  10. Brozyna A, VanMiddlesworth L, Slominski A (2008) Inhibition of melanogenesis as a radiation sensitizer for melanoma therapy. Int J Cancer 123, 1448-1456.
  11. Tuckey RC, Li W, Zjawiony JK, Zmijewski MA, Nguyen MN, Sweatman T, Miller D, Slominski A. (2008) Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc. FEBS J 275, 2585-2596.
  12. Tuckey RC,  Nguyen MN, Slominski A. (2008) Kinetics of vitamin D3 metabolism by cytochrome P450scc (CYP11A1) in phospholipid vesicles and cyclodextrin. Int J Biochem Cell Biol 40, 2619-2626.
  13. Slominski A (2008) Cooling skin cancer: Menthol inhibits melanoma growth. Am J Physiol: Cell Physiol 295, C293-C295.
  14. Blossom J, Altmayer S, Jones DM, Slominski A, Carlson J.A (2008) Volar melanotic macules in a gardener: A case report and review of the literature. Am J Dermatopathol 30, 612–619.
  15. Semak I, Korik E , Antonova M, Wortsman J, Slominski A (2008) Metabolism of melatonin by cytochrome P-450s in rat liver mitochondria and microsomes. J Pineal Res 45, 515-523.
  16. Van Beek E, Bodo E, Kromminga A, Gaspar E, Meyer  K, Zmijewski M, Slominski A, Wenzel BE, Paus R (2008) Thyroid hormones directly alter human hair follicle functions: Anagen prolongation, and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation. J Clin Endocrinol Metab  93, 4381-4388
  17. Zmijewski MA, Li W, Zjawiony JK, Sweatman TW, Chen J, Miller DD, Slominski AT (2008) Synthesis and photo-conversion of androsta- and pregna-5,7-dienes to vitamin D3-like derivatives. Photochem Photobiol Sci 7, 1570-1576.
  18. Zbytek B, Carlson JA, Granese J, Ross J, Mihm M, Slominski A (2008) Current concepts of metastasis in melanoma. Expert Rev Dermatol  3, 569-585.
  19. Bodo E, Kromminga A, Biro T, Istvan B, Gaspar E, Zmijewski M, van Beek E, Langein L,  Slominski A, Paus R (2008) Human female hair follicles are a direct, non-classical target for thyroid-stimulating hormone (TSH). J Invest Dermatol, 129, 1126-1139.


  1. Zbytek B, Slominski A (2007) CRH mediates inflammation induced by lipopolysaccharide in human adult epidermal keratinocytes. J Invest Dermatol 127, 730–732.
  2. Slominski A, Wortsman J, RC Tuckey, Paus R (2007) Differential expression of HPA axis homolog in the skin. Mol Cell Endocrinol 265-266, 143-149.
  3. Slominski A, Zmijewski M, Pisarchik A, Wortsman J (2007) Molecular cloning and initial characterization of african green monkey (Cercopithecus aethiops) corticotropin releasing hormone receptor type 1 (CRF1) from COS-7 cells. Gene 389, 154-162.
  4. Rohwedder A, Slominski A, Wolff M, Kredentser D, Carlson AJ (2007) Epidermodysplasia verruciformis and cutaneous human papillomavirus dna, but not genital human papillomavirus DNAs, are frequently detected in vulvar and vaginal melanoma. Am J Dermatopathol 29:13–17
  5. Rousseau K, Kauser S, Pritchard LE, Warhurst A, Oliver RL, Slominski A,  Wei ET, Thody AJ, Tobin DJ,  White A (2007) Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is secreted by human epidermal keratinocytes and melanocytes and stimulates melanogenesis. FASEB J 21, 1844-1856.
  6. Zmijewski M, Sharma R, Slominski A (2007) Expression of an equivalent of hypothalamic-pituitary-adrenal axis in adult retinal pigment epithelium. J Endocrinol, 193, 157–169.
  7. 180. Li W, Wang Z, Gududuru V, Zbytek B, Slominski AT, Dalton JT and Miller DD (2007) Structure-activity relationship studies of arylthiazolidine amides as selective cytotoxic agents for melanoma. Anticancer Res 27, 883-888.
  8. Paus R,  Klein J, Permana PA, Owecki M, Chaldakov GN, Bohm M, Hausman G, Lapiere CM, Atanassova P, Sowinski J, Fasshauer M, Hausman DB, Maquoi E, Tonchev AB, Peneva VN, Vlachanov KP, Fiore M, Aloe L, Slominski A, Reardon CL, Ryan, TJ, Pond CM (2007) What are subcutaneous adipocytes really good for…? Exp Dermatol 16, 45–70.
  9. Brozyna A, Zbytek B, Granese J, Ross J, Carlson JA, Slominski A (2007) Mechanism of UV-related carcinogenesis and its contribution to nevi/melanoma. Expert Rev Dermatol 2, 451-469.
  10. Slominski A (2007) A nervous breakdown in the skin: Stress and the epidermal barrier. J Clin Invest 117, 3166-3169.
  11. Carlson J.A., Linette G.P., Aplin A., Ng B., Slominski A. (2007)  Melanocyte receptors: Clinical implications and therapeutic relevanceDermatol Clin 25,  541-557.


  1. Arck PC, Slominski A, Theoharides TC, Peters EMJ, Paus R (2006) Neuroimmunology of stress: skin takes center stage. J Invest Dermatol 126:1697-704.
  2. Slominski A., Zbytek, B., Pisarchik, A., Slominski, R.M., Wortsman, J. (2006) CRH functions as a growth factor/cytokine in the skin. J Cell Physiol 206, 780-791
  3. Fischer T, Zbytek B, Sayre RM,  Apostolov EO, Basnakian AG, Sweatman TM, Wortsman J, Elsner P, Slominski A (2006) Melatonin increases survival of HaCaT keratinocytes by suppressing UV-induced apoptosis. J Pineal Res 40, 18-26.
  4. Slominski A, Zbytek B, Zmijewski M, Slominski RM, S Kauser, Wortsman J, DJ Tobin (2006)  Corticotropin releasing hormone and the skin  Front Biosci 11, 2230-2248.
  5. Slominski A., Zbytek B., Szczesniewski A., Wortsman J (2006) Cultured human dermal fibroblasts do produce cortisol. J Invest Dermatol 126, 1177-1178.
  6. Fischer T, Sweatman TM, Semak I, Sayre RM,  Wortsman J,  Slominski A (2006) Constitutive and UV-induced metabolism of melatonin in keratinocytes and cell-free systems. FASEB J  20, 1564-1566
  7. 167. Kauser S, Slominski A, Wei E, Tobin DJ (2006) Modulation of the human hair follicle pigmentary unit by CRH and urocortin peptides.  FASEB J 20, 882-895.
  8. Zbytek B, Pfeffer L, Slominski A (2006) CRH inhibits NF-κB activity in melanocyte via POMC signaling. Peptides 27, 3276-3283.
  9. Zbytek B, Wortsman J, Slominski A. (2006) Mechanisms of UVB stimulated corticotropin-releasing hormone and proopiomelanocortin production in the human melanocytes. Mol Endocrinol 20, 2539-2547.
  10. Slominski A (2006) Proopiomelanocortin (POMC) signaling system is operating in mast cells. J Invest Dermatol 126, 1934-1936.
  11. Slominski A,   Semak I, Wortsman J, Zjawiony J, Li  W, Zbytek B, Tuckey T (2006) An alternate pathway of vitamin D2 metabolism: Cytochrome P450scc (CYP11A1) mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2.  FEBS J 273, 2891-901. 
  12. Fisher T,Zmijewski M, Zbytek B, Sweatman TW, Slominski RM, Wortsman J, Slominski A (2006) Oncostatic effects of indole melatonin and expression of its cytosolic and nuclear  receptor in cultured human melanoma cell lines. Int J Oncol 29, 665-672.
  13. Jiang H, Wortsman J, Matsuoka L, Granese J, Carlson JA, Mihm M, Slominski A (2006) Molecular Spectrum of Pigmented Skin Lesions: From Nevus to Melanoma. Expert Rev Dermatol 1, 679-700.


  1. Zbytek B,  Pikula M, Slominski RM, Mysliwski A,Wei E, Wortsman  J, Slominski AT (2005) CRH triggers differentiation in HaCaT keratinocytes. British J Dermatol 152,474-480.
  2. Slominski A, Wortsman J,  Plonka PM, Schallreuter KU, Paus R,  Tobin DJ (2005) Hair follicle pigmentation. J Invest Dermatol 124: 13-21.
  3. Zbytek B, Slominski A (2005) CRH induces differentiation program in human adult epidermal keratinocytes. J Cell Physiol 203:118–126
  4. Carlson JA, Ross JS, Slominski A, Linette G, Mysliborski J, Hill J, Mihm MJr. (2005) Molecular markers in melanoma. J Amer Acad Dermatol 52:743-75
  5. Slominski A, Plonka PM, Pisarchik A, Smart JL, Tolle V, Wortsman J, Low MJ (2005) Preservation of eumelanin hair pigmentation in Pomc-gene knockout mice on a non-agouti (a/a) genetic background. Endocrinology 146, 1245–1253
  6. Slominski A, Wortsman J, Tobin DJ (2005) The cutaneous serotoninergic/melatoninergic system:  securing a place under the sun. FASEB J 19, 176-194.
  7. Slominski A, Zbytek B, Szczesniewski A, Semak I , Kaminski J, Sweatman T, Wortsman  J (2005) CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH.Am J Physiol Endocrinol Metab 288, E701–E706
  8. Slominski A (2005) Neuroendocrine system of the skin (William J Cunliffe Scientific Award lecture). Dermatology 211, 199-208
  9. Slominski A, Zbytek B, Semak I , Sweatman T, Wortsman  J (2005) CRH stimulates POMC activity and corticosterone production in dermal fibroblasts. J Neuroimmunol 162, 97– 102
  10. Linette G, Carlson JA, Slominski A,  Mihm MJr, Ross JS, (2005) Biomarkers in melanoma: Stage III and IV disease. Expert Rev. Mol. Diagn. 5, 65-74.
  11. Slominski A, Semak I , Zjawiony J, Wortsman  J, Li W, Szczesniewski A, Tuckey RT (2005) The cytochrome P450scc system opens an alternate pathway of vitamin D3metabolism. FEBS Journal 272, 480-4090.
  12. Semak I; Naumova M; Korik E; Terekhovich V; Wortsman J; Slominski A (2005).  A Novel Metabolic Pathway of Melatonin: Oxidation by Cytochrome c. Biochemistry 44, 9300-9307.
  13. Plonka PM, Michalczyk D, Popik M, Handjiski B, Slominski A, Paus R (2005) Splenic eumelanin differs from hair eumelanin in C57BL/6 mice. Acta Biochim Pol. 52, 433-441.
  14. Slominski A, Semak I , Zjawiony J, Wortsman  J, Gandy MN, Li J, Zbytek B, Li W, Tuckey RT (2005) Enzymatic metabolism of ergosterol by cytochrome P450scc (CYP11A1) to biologically active 17a,24-dihydroxyergosterol. Chemistry & Biology 12, 931-939
  15. Slominski A, Fischer T, Zmijewski MA, Wortsman J, Semak I ,  Zbytek B, Slominski RM, Tobin DJ (2005) On the role of melatonin in skin physiology and pathology. Endocrine 27,137-48


  1. Semak I, Korik E, Naumova M, Wortsman J, Slominski A (2004) Serotonin metabolism in rat skin: characterization by liquid chromatography – mass spectrometry. Arch Biochem Biophys 421, 61-66.
  2. Slominski A, Pisarchik A, Tobin DJ, Mazurkiewicz JE, Wortsman J (2004) Differential expression of cutaneous corticotropin releasing hormone system. Endocrinology 145, 941-950.
  3. Slominski A, Tobin DJ, Shibahara S, Wortsman J (2004) Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol Rev 84, 1155-1228.
  4. Zbytek B, Pffefer L, Slominski A (2004) Corticotropin-releasing hormone stimulates NF-kappaB in human epidermal keratinocytes. J Endocrinol 181, R1-R7.
  5. Pisarchik A, Slominski A (2004) Molecular and functional characterization of novel CRFR1 isoforms identified in the skin. Eur J Biochem 271, 2821-2830.
  6. Grabacka M, Placha W, Plonka PM, Pajak S, Urbanska K, Laidler P, Slominski A  (2004) Inhibition of melanoma metastases by fenofibrate Arch Derm Res 296, 54-58.
  7. Pisarchik A, Wortsman J, Slominski A (2004) A novel microarray to evaluate stress-related genes in skin: Effect of ultraviolet light radiation. Gene 341, 199-207.
  8. Slominski A, Pisarchik A, Wortsman J (2004) Expression of genes coding melatonin and serotonin receptors in rodent skin. Biochim Biophys Acta 1680, 67-70.
  9. Slominski A, Zjawiony J, Wortsman J, Semak I, Stewart J,  Pisarchik A, Sweatman T, Marcos J, Dunbar C, Tuckey RT (2004) A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin. Europ J Biochem 271, 4178-4188
  10. Semak, I. V.; Korik, E. O.; Naumova, M. V.; Slominski, A (2004)  New method for determination of arylalkylamine N-acetyltransferase activity by high pressure liquid chromatography and mass spectrometry.    Vestsi Natsyyanal'nai Akademii Navuk Belarusi, Seryya Biyalagichnykh Navuk  (2004),   (4),  69-73.


  1. Slominski A, Wortsman J (2003) Self-regulated endocrine system in the skin. Minerva Endocrinologica, 28, 135-143.
  2. Plonka P, Slominski A, Pajak S, Urbanska K (2003) Transplantable Melanomas in Gerbils (Meriones unguiculatus). II – Melanogenesis. Exp Dermatol 12, 356-364.
  3. Coburn SP, Slominski A, Mahuren JD, Wortsman J, Hessle L, Millan JL (2003) Cutaneous metabolism of vitamin B-6. J Invest Dermatol 120, 292-300.
  4. Wiesner B, B Roloff, Fechner K, Slominski A (2003) Intracellular calcium measurements of single human skin cells after stimulation with corticotropin-releasing factor and urocortin using confocal laser scanning microscopy. J Cell Sci 116, 1261-1268.
  5. Slominski A, Pisarchik A, Zbytek B, Tobin DJ, Kauser S, Wortsman J (2003) Functional activity of serotoninergic and melatoninergic systems expressed in the skin. J Cell Physiol 196, 144-153.
  6. Carlson JA, Slominski A, Linette G, Mihm CM, Jr., Ross JS (2003) Biomarkers in melanoma.  Part 1.  Predispostion, screening and diagnosis. Exp Rev Mol Diagn 3, 163-184.
  7. Carlson JA, Slominski A, Linette G, Mihm CM, Jr., Ross JS (2003) Biomarkers in melanoma.  Part II.  Staging, prognoses and detection of early metastases. Exp Rev Mol Diagn 3, 303-330.
  8. Slominski A (2003) b-endorphin/m-opiate receptor system in the skin  (Commentary). J Invest Dermatol 120, xii-xiii.
  9. Slominski A, Pisarchik A, Semak I, Sweatman T, Wortsman J (2003) Characterization of the serotoninergic system in C57BL/6 mouse skin. Eur J Biochem 270, 3335-3344.
  10. Slominski A, Wortsman J, Linton E, Pisarchik A, Zbytek B (2003) The skin as a model for the immunodulatory effects of corticotropin-releasing hormone. In “Mind over Matter – Regulation of Peripheral Inflammation by the CNS“, M Schaffer, C Stein, editors (Progress in Inflammation Research; M. J. Parnham,  series editor), pp149-176, 2003, Birkahauser Verlag, Basel.
  11. Slominski A, Pisarchik A, Johansson O, Jing  C, Semak I, Slugocki G, Wortsman J, (2003) Tryptophan hydroxylase (TPH) expression in human skin cells. Biochim Biophys Acta 1639, 80-86.
  12. Zbytek B, Pfeffer L, Slominski A (2003) CRH inhibits NF-kB pathway in human HaCaT keratinocytes. J Invest Dermatol 121, 1496-1499.
  13. Semak, I. V.; Korik, E. O.; Naumova, M. V,  Slominski, A (2003)  Interaction of products of peroxidase oxidation of mono-, di-, and trihydroxyflavones with glutathione.    Vestsi Natsyyanal'nai Akademii Navuk Belarusi, Seryya Medyka-Biyalagichnykh Navuk  (2003),   (4),  50-56.
  14. Korik, E. O.; Naumova, M. V.; Slominski, A.; Semak, I. V. (2003)  Probable mechanisms of formation of glutathione conjugates of quercetin and rutin.    Vestsi Natsyyanal'nai Akademii Navuk Belarusi, Seryya Medyka-Biyalagichnykh Navuk  (2003),   (4),  62-67.


  1. Carlson JA, Mu XC, Slominski A, Weismann K, Crowson AN, Malfetano J,Prieto VG, Mihm MC  (2002) Melanocytic proliferations associated with lichen sclerosus. Arch Dermatol 138, 77-87.
  2. Zbytek B, Mysliwski A, Slominski A, Wortsman J, Wei E, Mysliwska J (2002) Corticotropin-releasing hormone affects cytokine production in human HaCaT keratinocytes. Life Sci 70, 1013-1021.
  3. Slominski A, Wortsman J, Foecking M, Shackleton C, Gomez-Sanchez C, Szczesniewski A.  (2002) Gas chromatography/mass spectrometry characterization of corticosteroid metabolism in human immortalized keratinocytes, J Invest Dermatol 118, 310-315.
  4. Pisarchik  A,  Slominski  A (2002) Corticotropin releasing hormone receptor type 1: molecular cloning and investigation of alternative splicing in the hamster skin. J Invest Dermatol 118, 1065-1072.
  5. Slominski A, Semak I, Pisarchi A, ,  Sweatman T, Szczesniewski A, Wortsman J (2002) Conversion of L-tryptophan to serotonin and melatonin in melanoma cells. FEBS Lett 511, 102-106.
  6. Carlson A, Grabowski R, Mu XC, Del Rosario A, Malfetano J, Slominski A (2002) Possible mechanisms of hypopigmentation in lichen slerosus. Am J Dermatopathol 24, 97-107.
  7. Slominski A, Pisarchik A, Semak I,  Sweatman T, Wortsman J,  Szczesniewski A, Slugocki G, McNulty J, Kauser S, Tobin DJ, Jing C, Johansson O  (2002) Serotoninergic and melatoninergic systems are fully expressed in human skin. FASEB J 16, 896-898; full text FASEB J (April 23, 2002) 10.1096/fj.0.1-0952fje.
  8. Slominski A (2002). Coming of age of melanogenesis related proteins. Arch Path Lab Med 126, 775-777.
  9. Slominski A, Pisarchik A, Semak I,  Sweatman T, Szczesniewski A, Wortsman J (2002)  Serotoninergic system in hamster skin. J Invest Dermatol 119, 934-942.
  10. Slominski A, Wortsman J, Kohn L, Ain KB, Venkataraman GM, Pisarchik A,Chung JH, Giuliani C, Thornton M, Slugocki G,. Tobin DJ (2002) Expression of hypothalamo-pituitary-thyroid axis related genes in the human skin.  J Invest Dermatol 119, 1449-1455.


  1. Slominski A, Carlson A, Wortsman J, Mihm M (2001) The role of molecular biology in diagnostic pathology of melanoma. Meth Mol Medicine 61, 123-163
  2. Quevedo MA, Slominski A, Pinto W, Wei E, Wortsman J (2001). Pleiotropic effects of corticotropin releasing hormone (CRH) on normal human keratinocytes. In Vitro Cell Develop Biol 37A, 50-54.
  3. Curry JL, Pinto W, Nickoloff BJ, Slominski AT (2001). Human keratinocytes express functional a-MSH (MC1-R) Receptors.  In Vitro Cell Develop Biol 37,234-236.
  4. Carlson KT, Stair Navy S, Wei ET, Sadie W, Filov VA, Rezsova VV, Slominski A, Quillan JM (2001) Inhibition of mouse melanoma cell proliferation by corticotropin releasing hormone and its analogs. Anticancer Res 21, 1173-1180.
  5. Roloff D, Gomez-Sanchez CE, Foecking MF, Wortsman J, Slominski A (2001) Steroidogenesis in the human skin: 21-hydroxylation in cultured keratinocytes. J Steroid Biochem Mol Biol 78, 77-81.
  6. Slominski A, Wortsman J, Carlson A, Matsuoka L, CM Balch,  Mihm M (2001) Malignant melanoma: An update. Arch Pathol Lab Med 125, 1295-1306.
  7. Slominski A, Wortsman J, Pisarchik A, Zbytek A, Linton  EA, Mazurkiewicz J, Wei ET  (2001) Cutaneous expression of corticotropin releasing hormone (CRH), urocortin and CRH receptors. FASEB J 15, 1678-1693.
  8.   Mahuren JD, Coburn SP, Slominski A, Wortsman J (2001) Microphosphate determination provides a general method for measuring the activity of phosphatases using physiological, nonchromogenic substrates such as lysophosphatidic acid. Anal Biochem 298, 241-245.
  9. Pisarchik  A,  Slominski  A (2001) Alternative splicing of CRH-R1 receptors in human and mouse skin: identification of new variants and their differential expression. FASEB J 15, 2754-2756; full text FASEB J (October 15, 2001) 10.1096/fj.01-0487fje.


  1. Cieszka K, Romanowska B, Elas, M, Pajak S, Paziewski E, Bryk J, Kukielczak B, Slominski A, Zygulska- Mach H, Lukiewicz S (2000) Experimetal ruthenium plaque therapy of amelanotic and melanotic melanomas growing in hamster eye. Melanoma Res 10, 26-35.
  2. Slominski A, Roloff B, Zbytek B, Wei ET, Fechner K, Curry J, Wortsman J (2000) Corticotropin releasing hormone (CRH) and related peptides can act as bioregulatory factors in human keratinocytes. In Vitro Cell Develop Biol 36, 211-216.
  3. Slominski A, Roloff B, Curry J, Dahiya M, Szczesniewski A, Wortsman J (2000) The skin produces urocortin. J Clin Endocrinol Metab 85, 815-823
  4. Slominski A, Gomez-Sanchez Celso, Foecking MF, Wortsman J (2000) Active steroidogenesis in the normal rat skin. Biochim Biophys Acta 1474, 1-4.
  5. Slominski A, Wortsman J, Luger T, Paus R, Salomon S (2000) Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol Rev 80, 979-1020.
  6. Slominski A, Wortsman J (2000) Neuroendocrinology of the skin. Endocrine Rev 21, 457-487.
  7. Mazurkiewicz JE, Corliss D, Slominski A (2000) Spatiotemporal expression, distribution, and processing of POMC and POMC-derived peptides in murine skin. J Histochem Cytochem 48, 905-914.
  8. Slominski A, Wortsman J, Szczesniewski A (2000) Liquid chromatography-mass spectrometry  detection of  corticotropin-releasing hormone and proopiomelanocortin-derived peptides in human skin. J Clin Endocrinol Metab 85, 3575-3581.
  9. Slominski A, Malarkey WB, Wortsman J, Asa S, Carlson A (2000) Human skin expresses growth hormone (GH), but not the prolactin (PRL) gene. J Lab Clin Med 136, 476-481.
  10. Cascinelli N, Heerlyn M, Schneeberger A, Kuwert C, Slominski A, Armstrong C,Belli F, Lukiewicz S, Maurer D, Ansel J, Stingl G, Saida T (2000) What is the most promising strategy for the treatment of metastasizing melanoma? Exp Dermatol 9, 439-451.


  1. Slominski A, Heasley D, Ermak G, Mazurkiewicz JE, Baker J, Carlson A (1999) Expression of proopiomelanocortin (POMC) derived melanocyte stimulating hormone (MSH) and ACTH peptides in skin of basal cell carcinoma patients. Human Pathology 30, 208-215.
  2. Wood JM, Jimbow K, Boissy RE, Slominski A, Plonka P, Slawinski J, Wortsman J, Tosk J (1999) What’s the use of generating melanin? Exp Dermatol 8, 153-164.
  3. Birkle S,  Ren S, Slominski  A, Zeng  G, Gao L, Kasama T, Yu R K.  (1999) Down regulation of the expression of O-acetyl-GD3 by the O-acetylesterase gene in hamster melanoma cells: effects on cellular proliferation, differentiation, and melanogenesis.  J Neurochem 72, 954-961.
  4. Slominski A, Gomez-Sanchez Celso, Foecking MF, Wortsman J (1999) Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells. FEBS Lett 445, 364-366.
  5. Slominski A, Ermak G, Wortsman J (1999) Modification of melanogenesis in cultured human melanoma cells. In Vitro Cell Develop Biol 35, 564-565.
  6. Slominski A, Botchkarev V, Choudhry  M, Fazal,  N,  Fechner,  K, Furkert,  J, Krause, E, Roloff, B.; Sayeed,  M.; Wei,  E.; Zbytek, B.; Zipper, J.;  Wortsman, J.; Paus, R. (1999)  Cutaneous expression of CRH and CRH-R: is there a “skin stress system”? Ann NY Acad Sci 885, 287-311.
  7. Paus R, Botchkarev VA, Botchkareva NV, Fechner K, Furkert J, Roloff B, Slominski A (1999) The skin POMC system (SPS): leads and lessons from the hair follicle.” Ann NY Acad Sci 885, 350-363.
  8. Chakraborty A, Pawelek JM, Bolognia J, Funasaka Y, Slominski A (1999) UV light and MSH receptors. Ann NY Acad Sci 885, 100-116.
  9. Botchkarev VA, Slominski A, Botchkareva NV, Roloff B, Luger T, Paus R (1999) Developmentally regulated expression of a-MSH and MC-1 receptor in C57BL/6 mouse skin suggests functions beyond pigmentation. Ann NY Acad Sci 885, 433-439.
  10. Mazurkiewicz JE, Corliss D, Slominski A (1999) Differential temporal and spatial expression of POMC mRNA and of the production of POMC peptides during the murine hair cycle. Ann NY Acad Sci 885, 427-429.
  11. Slominski A, Botchkarev V, Botchkarev N, Chakraborty A, Luger T, Uenalan M, Paus R (1999) ACTH production in C57BL/6 mouse skin. Ann NY Acad Sci 885, 448-450.
  12. Slominski A, Wortsman J, Carlson A, Nickoloff B, McClatchey K  (1999) Molecular pathology of soft tissue and bone tumors. A review. Arch Pathol Lab Med 123, 146-1259.
  13. Tobin DJ, Slominski A, Botchkarev V, Paus R (1999) The fate of hair follicle melanocytes during the hair growth in mice. J Invest Dermatol Symp Proc 4,  323-332.


  1. Luger TA. Scholzen T, Brzoska T, Becher E, Slominski A, Paus R (1998) Cutaneous immunomodulation and coordination of skin stress responses by alpha-melanocyte-stimulating hormone. Ann NY Acad Sci 840, 381-394.
  2. Slominski A, Pawelek J (1998) Animals Under the Sun: Effects of UV Radiation on Mammalian Skin. Clin Dermatol 16, 503-515.
  3. Slominski A, Paus R, Mihm M (1998). Inhibition of melanogenesis as an adjuvant strategy for the treatment of melanotic melanomas. Selective review and hypothesis. Anticancer Res 18, 3709-3716
  4. Schallreuter K, Slominski A, Pawelek J, Jimbow K, Gilchrest B (1998) What control melanogenesis? Exp Dermatol 7, 143-150.
  5. Slominski A, Wortsman J, Nickoloff B, McClatchey K,  Mihm, MC , Ross J (1998)  Molecular pathology of melanoma. Am J Clin Pathol 110, 788-794.
  6. Roloff B, Fechner K, Slominski A, Furkert J, Botchkarev VA, Bulfone-Paus S, Zipper J,  Krause K, Paus R (1998) Hair Cycle-Dependent Expression of Corticotropin Releasing Hormone (CRH) and CRH Receptors (CRH-R) in Murine Skin. FASEB J 12, 287-297.
  7. Slominski A, Ermak G, Mazurkiewicz JE, Baker J, Wortsman J (1998) Characterization of corticotropin releasing hormone (CRH) in human skin. J Clin Endocrinol Metab  83, 1020-1024.
  8. Slominski A, Botchkarev V, Botchkarev N, Chakraborty A, Luger T, Uenalan M, Paus R (1998) Hair cycle dependent production of ACTH in mouse skin. Biochim. Biophys. Acta 1448, 147-152.
  9. Fazal N, Slominski A, Choudhry MA, Wei ET, Sayeed MM (1998) Effect of CRF and related peptides on calcium signalling in human and rodent melanoma cells. FEBS Lett 435, 187-190. 
  10. Slominski A (1998) Identification of b-endorphin, a-MSH and ACTH peptides in cultured human melanocytes, melanoma and squamous cell carcinoma cells. Exp Dermatol 7, 213-216


  1. Ermak G, Slominski A (1997) Production of  POMC, CRH-, ACTH- and a-MSH- receptor mRNA and expression of tyrosinase gene in relation to hair cycle and dexamethasone treatment in the C57BL/6 mouse skin. J Invest Dermatol 108, 160-167.
  2. Slominski A, Goodman-Snitkoff G, Maurer M, Paus R (1997) Hair cycle associated changes in splenocyte proliferation. In Vivo 11, 101-102.
  3. Furkert J, Klug U, Slominski A, Eichmuller S, Mehlis B, Kertscher U, Paus R (1997) Identification and measurement of b-endorphin levels in the skin during induced hair growth in mice. Biochim Biophys Acta 1336, 315-322.


  1. Slominski A, Ermak, Hwang J, Mazurkiewicz J, Corliss, Eastman A (1996) The expression of proopiomelanocortin (POMC) and of corticotropin releasing hormone receptor (CRH-R) genes in mouse skin. Biochim Biophys Acta 1289, 247-251.
  2. Slominski A, Paus R, Plonka P, Handjinski B, Maurer M, Chakraborty A, Mihm M (1996) Pharmacological disruption of hair follicle pigmentation as a model for studying the melanocyte response to and recovery from cytotoxic damage in situ. J Invest Dermatol 106, 1203-1211.
  3. Slominski A, Mihm MC (1996) Potential mechanism of skin response to stress. Int J Dermatol 35, 849-851.
  4. Chakraborty A, Funasaka Y, Slominski A, Ermak G, Hwang J, Pawelek J, Ichihashi M (1996) Production an release of proopiomelanocortin (POMC) derived peptides by human melanocytes and keratinocytes in culture: Regulation by UVB. Biochim Biophys Acta 1313, 130-138.
  5. Pajak S, Cieszka K, Plonka P, Lukiewicz S, Mihm M, Slominski A (1996) Transplantable melanomas in gerbils (meriones unguiculatus). I. Origin, morphology and growth rate. Anticancer Res 16, 1203-1208.
  6. Slominski A, Baker J, Rosano T, Guisti LW, Ermak G, Grande M, Gaudet SJ (1996) Metabolism of serotonin to N-acetylserotonin, melatonin and 5-hydroxytryptamine in hamster skin culture. J Biol Chem 271, 12281-12286.
  7. Slominski A, Ermak G, Mihm MC (1996) ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin. J Clin Endocrinol Met 81, 2746-2749.
  8. Slominski A, Baker J, Ermak G, Chakraborty A, Pawelek J (1996) UVB stimulates production of corticotropin releasing factor (CRF) by human melanocytes. FEBS Lett 399, 175-176.


  1. Paus R, Slominski A, Czarnetzki B (1995). Is alopecia areata an autoimmune-response against melanogenesis-related proteins, exposed by abnormal MHC class I expression in the anagen hair bulb?  Yale J Biol Med 66, 541-554.
  2. Slominski A, Ross J, Mihm, MC (1995)  Cutaneous melanoma: pathology, relevant prognostic indicators and progression.  British Medical Bulletin 51, 548-569.
  3. Chakraborty A, Slominski A, Ermak G, Hwang J, Pawelek J (1995) Ultraviolet and melanocyte-stimulating hormone (MSH) stimulate mRNA production of a-MSH receptors and proopiomelanocortin-derived peptides in mouse melanoma cells and transformed keratinocytes. J Invest Dermatol 105, 655-659.
  4. Slominski A, Ermak, Hwang J,Chakraborty A, Mazurkiewicz J, Mihm M (1995) Proopiomelanocortin, corticotropin releasing hormone  and  corticotropin releasing hormone receptor genes are expressed in human skin. FEBS Lett  374, 113-116.


  1. Slominski A, Paus R. (1994) Towards defining receptors for L-tyrosine and L-DOPA. Mol Cell Endocrinol 99, C7-C11.
  2. Slominski A, Chassalerris N, Mazurkiewicz J, Paus R (1994). Murine skin as a target for melatonin bioregulation. Exp Dermatol 3, 45-40.
  3. Paus R, Maurer M,  Slominski A, Czarnetzki B (1994) Mast cell involvement in murine hair growth.  Developmental Biol 163, 230-240.
  4. Slominski A, Paus R, Plonka P, Maurer M, Chakraborty A, Pruski D, Lukiewicz S. (1994) Melanogenesis during the anagen-catagen-telogen transformation of the murine hair cycle. J Invest Dermatol 102, 862-869.


  1. Slominsk A, Pruski D (1993)  Melatonin inhibits proliferation and melanogenesis in rodent melanoma cells. Exp Cell Res 206, 189-294.
  2. Ren SL, Ariga T, Scarsdale JN, Zhang Y, Slominski A, Livingston PO, Ritter G, Kushi Y, Yu RK (1993).  Characterization of a hamster melanoma associated ganglioside antigen as 7-0-acetylated disialoglangloside GD3.  J Lipid Res 34, 1565-1572.
  3. Gaudet S, Slominski A, Etminan M, Pruski D, Paus R, Namboodiri MAA (1993). Identification and characterization of two isozymic forms of arylamine N-acetyltransferase in Syrian hamster skin.  J Invest Dermatol 101, 650-656.
  4. Slominski A, Wortsman J, Mazurkiewicz J, Matsuoka L, Lawrence K, Gorbani A, Paus R (1993).  Detection of the proopiomelanocortin-derived antigens in normal and pathologic human skin.  J Lab Clin Med 122, 658-666.
  5. Slominski A, Paus R, Schaderdorf D (1993). Melanocytes are sensory and regulatory cells of epidermis. J Theor Biol 164, 103-120.
  6. Slominski A, Paus R, Wortsman J (1993) On the potential role of proopiomelanocortin in skin physiology and pathology. Mol  Cell Endocrinol 93, C1-C6.
  7. Slominski A, Paus R (1993)  Bomirski melanomas: A versatile and powerful model for pigment cell and melanoma research.  Int J Oncology  2, 221-228.
  8. Slominski A, Paus R (1993).  Melanogenesis is coupled to murine anagen: Toward new concepts for the role of melanocytes and the regulation of melanogenesis in hair growth.   J Invest Dermatol 101 , 90S-97S.


  1. Slominski A, Paus R, Mazurkiewicz J (1992).  Proopiomelanocortin expression in the skin during induced hair growth in mice. Experientia 48, 50-54.
  2. Slominski A, Costantino R, Wortsman J, Paus R, Ling N (1992)  Melanotropic activity of gamma MSH peptides in melanoma cells.  Life Sci 50, 1103-1108.
  3. Slominski A, Goodman-Snitkoff G (1992). DOPA inhibits induced proliferative activity of murine and human lymphocytes.  Anticancer Res 12, 753-756.
  4. Slominski A, McNeely T, Pawelek J (1992). Insulin receptor proteolysis in insulin resistant variants of Cloudman S91 melanoma cells.  Melanoma Res 2,115-122.
  5. Slominski A, Pruski D (1992). L-DOPA binding sites in rodent melanoma cells. Biochim Biophys Acta 1139,  324-328.
  6. Slominski A, Friedrich T (1992)  L-DOPA inhibits in vitro phosphorylation of melanoma glycoproteins. Pigment Cell Res 5, 396-400.
  7. Li L, Paus R,  Slominski A, Hoffman R (1992). Skin histoculture assay for studying the hair cycle.  In Vitro Cell Dev Biol 28A  695-698.


  1. Slominski A, Paus R, Costantino R (1991)  Differential expression and activity of melanogenesis-related proteins during induced hair growth in mice.  J Invest Dermatol 96, 172-179.
  2. Howe J, Costantino R, Slominski A.(1991)  On the putative mechanism of induction and regulation of melanogenesis by L-tyrosine.  Acta Derm Veneorol (Stockh) 71, 15-152.
  3. Slominski A, Costantino R (1991).  L-tyrosine induces tyrosinase expression via a posttranscriptional mechanism.  Experientia 47, 721-725.
  4. Slominski A, Costantino R (1991). Molecular mechanism of tyrosinase regulation by L-DOPA. Life Sci 48,2075-2079.
  5. Slominski A, Paus R, Wortsman J (1991).  Can some melanotropins modulate keratinocyte proliferation?  J Invest Derm 97, 747.
  6. Slominski A, Costantino R, Howe J, Moellmann G (1991).  Molecular mechanism governing melanogenesis in hamster melanomas:  Relative abundance of tyrosinase and catalase-B (gp 75).  Anticancer Res 11, 257-263.
  7. Slominski A (1991).  POMC gene expression in hamster and mouse melanoma cells. FEBS Lett 291, 165-168.
  8. Slominski A (1991).  L-tyrosine binding proteins on melanoma cells. In Vitro Cell Dev Biol 27A, 735-738.
  9. Slominski A, Paus R, Mazurkiewicz J (1991).  Proopiomelanocortin expression and potential function of proopiomelanocortin products during induced hair growth in C57 Bl-6 mouse. Ann NY Acad Sci 642, 459-462.


  1. Slominski A, Paus R (1990) Are L-tyrosine and L-dopa hormone-like bioregulators. J Theor Biol 143, 123-138.


  1. Slominski A, Moellmann G, Kuklinska E (1989) L-tyrosine, L-dopa and tyrosinase as positive regulators of the subcellular apparatus of melanogenesis in Bomirski Ab amelanotic melanoma.  Pigment Cell Res 2. 109-116.
  2. Slominski A, Moellmann G, Kuklinska E (1989) MSH inhibits growth in a line of amelanotic hamster melanoma cells and induces increases in cAMP levels and tyrosinase activity without inducing melanogenesis. J Cell Sci 92, 551-559.
  3. Slominski A (1989) L-tyrosine induces synthesis of melanogenesis related proteins. Life Sci 45, 1799-1803.
  4. Slominski A, Jastreboff P, Pawelek J (1989) L-tyrosine stimulates induction of tyrosinase activity by MSH and reduces cooperative interactions between MSH receptors in hamster melanoma cells. Biosci Rep 9, 579-587.
  5. Ren S, Slominski A, Yu R (1989) Glycosphingolipids in Bomirski transplantable hamster melanomas. Cancer Res 49,  7051-7056.
  6. Slominski A, Paus R, Bomirski A (1989) Hypothesis: a possible role of the melatonin receptor in vitiligo. J Royal Soc Med 82, 539-541.


  1. Slominski A, Moellmann G, Kuklinska E, Bomirski A, Pawelek J (1988) Positive regulation of melanin pigmentation by two key substrates of the melanogenic pathway: L-tyrosine and L-dopa. J Cell Sci 89, 287-296.
  2. Bomirski A, Slominski A, Bigda J (1988)  The natural history of a family of transplantable melanomas in hamsters.  Cancer Met Rev 7, 95-119.
  3. Pawelek  J, Bolognia J, McLane J, Murray M, Osber M, Slominski A (1988) A possible role of melanin precursors in regulating both pigmentation and proliferation of melanocytes. Adv Pigment Res Prog Clin Biol Res 256, 143-155.
  4. Moellmann G, Slominski A, Kuklinska E, Lerner AB (1988) Regulation of melanogenesis in melanocytes. Pigment Cell Res Suppl 1, 79-871.


  1. Bomirski A, Wrzolkowa T, Arendarczyk M, Bomirska M, Kuklinska E, Slominski A, Moellmann G (1987)  Pathology and ultrastructural characteristics of a hypomelanotic variant of transplantable hamster melanoma with high tyrosinase activity. J Invest Derm 89, 469-473.
  2. Slominski A, Pawelek J (1987) MSH binding in Bomirski amelanotic melanoma cells is stimulated by L-tyrosine. Biosci Rep 7, 949-954.


  1. Bomirski A, Slominski A (1986) Ultrastructural aspects of melanization of hamster Ab amelanotic melanoma in primary cell culture. Acta Derm Venereol (Stockh) 66, 520-528.
  2. McNeely T, Slominski A, Bomirski A, Pawelek J (1986) Phosphorylation of protein of approximately 90 K daltons is a factor  in the regulation of melanoma cell growth by insulin and the expression of high affinity receptors for insulin. In: Advances in Gene Technology: Molecular Biology of the Endocrine System. PuetD et al. (eds.). ICSU Short Reports 4, p55. Cambridge University Press, Cambridge MA.


  1. Slominski A (1985) Some properties of Bomirski Ab amelanotic melanoma cells, which underwent spontaneous melanization in primary cell culture. Growth kinetics, cell morphology, melanin content and tumorogenicity. J Cancer Res Clin Oncol 109, 29- 37.
  2. Slominski A, Bomirski A (1985) Phenotypic changes of Ab hamster melanoma during long-term culture. Anticancer Res 5, 403-410.
  3. Scislowski PWD, Slominski A, Bomirski A, Zydowo M (1985) Metabolic characterization of three hamster melanoma variants. Neoplasma 32, 593-598.


  1. Slominski A, Scislowski PWD, Bomirski A (1984) Biochemical characterization of three hamster melanoma variants. I. Tyrosinase activity and melanin content. Int J Biochem 16, 323-326.
  2. Scislowski PWD, Slominski A, Bomirski A (1984) Biochemical characterization of three hamster melanoma variants. II. Glycolysis and oxygen consumption. Int J Biochem 16,  327-331.
  3. Slominski A, Bomirski A, Scislowski PWD, Arendarczyk M (1984) Effect of tissue selection on melanization of MI melanoma. Neoplasma 31, 551-556.
  4. Slominski A, Bomirski A, Scislowski PWD, Zolnierowicz S (1984) Effects of actinomycin D and cycloheximide on the increase of tyrosinase activity of hamster melanoma cells in vitro. Biosci Rep 4, 1059-1064.


  1. Slominski A, Kobzdej D (1983) Transplantability of Bomirski melanomas in Syrian hamsters. Neoplasma 30, 51-56.
  2. Scislowski PWD, Slominski A (1983) The role of NADP-dependent dehydrogenases in hydroxylation of tyrosine in hamster melanoma. Neoplasma 30, 239-243.
  3. Slominski A (1983) Rapid melanization of Bomirski amelanotic melanoma in cell culture. Biosci Rep 3, 189-194.
  4. Slominski A, Scislowski PWD, Bomirski A (1983) Tyrosinase activity in primary cell culture of amelanotic melanoma cells. Biosci Rep 3, 1027-1034.