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Bill Turbitt, PhD

Bill Turbitt, PhD Postdoctoral Fellow
Nutrition Obesity Research Center
University of Alabama at Birmingham
WTI 301C, 1824 6th Ave. S.
Birmingham, AL 35233
Office: (205) 996-0166
E-mail: wturbitt@uab.edu
Full CV

Dr. Turbitt joined the University of Alabama at Birmingham (UAB) Nutrition Obesity Research Center (NORC) Training Program (T32DK062710) as a Postdoctoral Scholar on August 21, 2017 after completing his graduate degree in Integrative and Biomedical Physiology at The Pennsylvania State University in August 2017. Bill’s dissertation experiments controlled for weight and examined the effects of mild dietary restriction, exercise, or the combination of diet and exercise on the inflammation-immune axis and tumor progression in a preclinical metastatic breast cancer model. Additional studies were designed to determine if diet and exercise could augment the response to emerging immunotherapeutic treatments. Bill’s postdoctoral research at UAB focuses on the role of diet-induced obesity and/or calorie restriction mimetic administration on anti-tumor immunity and immunotherapeutic efficacy in preclinical models of breast and renal cancer.

Education

  • Postdoctoral Scholar, University of Alabama at Birmingham, August 2017 – present
  • Ph.D., The Pennsylvania State University (Integrative and Biomedical Physiology), June 2017
  • B.S., The Pennsylvania State University (Biobehavioral Health), May 2010

Publications

  1. Turbitt, W.J., Xu, Y., Hamilton, A.A., Mastro, A.M., Rogers, C.J. (2018). Moderate physical activity in weight stable mice reduces 4T1.2 tumor burden to the same extent as PD-1 checkpoint blockade in sedentary, weight gain controls. (in preparation).
  2. Turbitt, W.J., Xu, Y., Sosnoski, D.M., Collins, S., Mastro, A.M., Rogers, C.J. (2018). Weight maintenance in combination with a whole tumor cell vaccine reduces mammary tumor cell growth and enhances anti-tumor immunity. (in preparation).
  3. Collins, S., Turbitt, W.J. (co-first author), Rogers, C.J. (2018). Obesity accelerates pancreatic tumor growth and increases the accumulation of Gr-1+/CD11b+ myeloid-derived suppressor cells. (in preparation).
  4. Turbitt, W.J. (co-first author), Xu, Y., Sosnoski, D.M., Collins, S., Meng, H., Mastro, A.M., Rogers, C.J. (2018). Physical activity in weight stable mice prevents mammary tumor growth and metastases by altering the tumor microenvironment and reducing protumorigenic factors. (in preparation).
  5. Boi, W.K., Orlandella, R. M., Gibson, J.T., Makkouk, A., Nandagopal, L., Gross, B.P., Turbitt, W.J., Starenki, D., Joshi, V.B., Meyers, R.M., Sorge, R.E., Salem, A.K., Weiner, G.J., Li, P., Yang, E., Marquesz-Lago, T.T., Norian, L.A. (2018). Host obesity impairs the efficacy of novel combinatorial checkpoint blockade therapeutics. (submitted).
  6. Kraemer, W.J., Kennett, M.J., Mastro, A.M., McCarter, R.J., Rogers, C.J., DuPont, W.H., Flanagan, S.D., Turbitt, W.J., Fragala, M.S., Post, W.M., Hymer, W.C. (2017). Bioactive growth hormone in older men and women: It’s relationship to immune markers and healthspan. Growth Hormone & IGF Research; 34:45-54.
  7. Turbitt, W.J., Black, A.J., Collins, S., Meng, H., Xu, H., Washington, S., Aliaga, C., El-Bayoumy, K., Manni, A., Rogers, C.J. (2015). Fish oil differentially alters T cell function and tumor growth and induces the emergence of Gr1+/CD11b+ cells in two models of mammary carcinogenesis. Nutrition and Cancer; 67(6), 965-975.
  8. Sinha, R., Cooper, T.K., Rogers, C.J., Sinha, I., Turbitt, W.J., Calcagnotto, A., Perrone, C.E., J.P. Richie, J.P. (2014). Dietary methionine restriction inhibits prostatic intraepithelial neoplasia in TRAMP mice. Prostate; 74(16):1663-1673.

Acknowledgement and Disclaimer
The trainee's projects are supported by Grant Number T32DK062710 from the National Institute of Diabetes and Digestive and Kidney Diseases. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Diabetes and Digestive and Kidney Diseases or the National Institutes of Health.

Years: July 2017 - present
Mentor(s): Lyse A. Norian, PhD – primary mentor; Courtney M. Peterson, PhD – secondary mentor