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Douglas Moellering, Ph.D.

Douglas R. Moellering, PhD Associate Professor
WEBB 429
1675 University Blvd.
Birmingham, AL. 35206-3360
Phone: (205) 996-2660 Fax: (205) 996-5895
E-mail: dmoellering@uab.edu
Full CV

Dr. Moellering is an Associate Professor of Nutrition Sciences, a scientist in the School of Medicine, Center for Free Radical Biology (CFRB), a scientist in the School of Medicine, Comprehensive Diabetes Center, a scientist in the Academic Joint Departments, Center for Exercise Medicine, a scientist in the School of Medicine, Comprehensive Center for Healthy Aging, an associate scientist in the School of Health Professions, Nutrition Obesity Res Center (NORC), an associate scientist in the School of Medicine, Minority Health & Research Center, and a scientist in the School of Health Professions Diabetes Research Center (DRC). Dr. Moellering is the Director of the Bioanalytical Redox Biology (BARB) Core facility, serving multiple investigators in measuring highly functional mitochondrial physiology, bioenergetics, enzymatic activity, and markers of oxidative stress.

Education

Thomas More College, Crestview Hills, KY
BA, Biology, 1991

University of Alabama at Birmingham
MS, Basic Medical Sciences (Physiology & Biophysics), 1995

University of Alabama at Birmingham
PhD, Cellular and Molecular Pathology, 2003

Post-Graduate Training

University of Alabama at Birmingham
Postdoctoral Fellow, Department of Nutrition Sciences, 2003-8

Research Interest

Eighty percent of the air we breathe and most of the food that is consumed and absorbed are metabolized within mitochondria to produce 90 percent of the energy in the form of ATP necessary for use in all cellular processes, including exercise, growth, and reproduction. Evidence has been accumulating that many diseases involve mitochondrial dysfunction with concomitant increased reactive oxygen and/or nitrogen species formation. Some of these diseases include insulin resistance, type 2 diabetes mellitus (T2DM), Parkinson's disease, Alzheimer's disease, cardiovascular disease, atherosclerosis, cancer, obesity, and Harman’s free-radical theory of aging (although aging is not a disease). These reactive products are called free radicals since they contain one or more unpaired electrons. Free radical-mediated alterations in energy production, tissue injury, and human disease are pervasive, and still poorly understood. Our research interests involve mitochondrial physiology, bioenergetics, and free radical-mediated tissue injury and disease pathologies. Currently our research is focused on mitochondrial free-radical production contributing to altered bioenergetics, the development of obesity, insulin resistance and T2DM, increased cardiovascular disease susceptibility, and aging.