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Glenn C. Rowe, PhD

Glenn C. Rowe PhD
Assistant Professor
Department of Medicine, Division of Cardiovascular Disease
McCallum Basic Health Sciences Bldg, Room 280
1918 University Blvd, Birmingham, AL 35294
Tel: (205) 975-0100
Full CV

Lab website:

Dr. Glenn C. Rowe received his B.S. in Biology from Brandeis University (2001) and his Ph.D. in Molecular, Cellular and Developmental Biology from Yale University (2007) where he studied the transcriptional regulation of factors that control bone and adipose tissue homeostasis. He completed his post-doctoral training at the Beth Israel Deaconess Medical Center, where his work focused on the role of transcriptional coactivators in regulating mitochondrial metabolism.

He joined the University of Alabama at Birmingham faculty in 2014 where he is currently Assistant Professor of Medicine in the Division of Cardiovascular Disease. His research interest focuses on understanding the cellular and molecular mechanisms underlying metabolism in the cardiovascular and musculoskeletal system. Dr. Rowe has a K01 Career Development award through the NIH-NIAMS, and is also a recent recipient of the UAB Pittman Scholar Award (2016).

The research interest of the Rowe laboratory focuses on understanding the molecular pathways that influence mitochondrial metabolism in response to diet and exercise, in order to improve mitochondrial function and reduce the deleterious effects of the metabolic syndrome.

Specifically, the lab studies the PGC-1 family of transcriptional coactivators and the molecular pathways they regulate in striated muscle to maintain normal mitochondrial function (including biogenesis, oxidative capacity and dynamics) and normal metabolic function. The laboratory utilizes a variety of molecular techniques, cell-based assays as well as genetically modified mouse models to understand the molecular mechanisms that control mitochondrial function.

Projects in the lab revolve around the following areas 1.) the study of mitochondrial dynamics in response to exercise, 2.) the effect of exercise on angiogenesis and mitochondrial metabolism, 3.) the characterization of new regulators of mitochondrial metabolism in striated muscle and 4.) contribution of mitochondrial function to whole body energy homeostasis.


  • 2016
  • 2014
  • 2013
  • 2012
  • 2011
  • pre 2011
  1. He L, Hamm JA, Reddy A, Sams D, Peliciari-­Garcia RA, McGinnis GR, Bailey SM, Chow C, Rowe GC, Chatham JC, Young ME. Biotinylation: A Novel Posttranslational Modification Linking Cell Autonomous Circadian Clocks with Metabolism. AJP Heart and Circulatory Physiology. 2016 Jun 1;;310(11):H1520-­32.
  2. Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman D, Lecker S, Krishnaia S, Weljie A, Baur J, Kasper DL, Arany Z. A metabolite of branched chain amino acids drives vascular fatty acid transport and causes glucose intolerance. Nat Med. 2016 Apr;;22(4):421-­6.
  3. Iacovelli J, Rowe GC, Khadka A, Diaz-­Aguilar D, Spencer C, Arany Z, Saint-­Geniez M. PGC-­1-­alpha induces human RPE oxidative metabolism and antioxidant capacity. Invest Ophthalmol Vis Sci. 2016 Mar 1;;57(3):1038-­1051.
  4. Safdar A, Khrapko K, Flynn J, Saleem A, De Lisio M, Johnston A, Kratysberg Y, Samjoo I, Kitaoka Y, Ogborn D, Little J, Raha S, Parise G, Akhtar M, Hettinga B, Rowe GC, Arany Z, Prolla T, Tarnopolsky M. Exercise-­induced mitochondrial p53 repairs mtDNA mutations in mutator mice. Skeletal Muscle 2016 Jan 16;; 6(7).
  1. Rowe GC*, Raghuram S*, Jang C, Nagy J, Patten IS, Goyal A, Chan MC, Liu L, Jiang A, Spokes KC, Beeler D, Dvorak H, Aird W, and Arany Z. PGC-1α Induces SPP1 to Activate Macrophages and Orchestrate Functional Angiogenesis in Skeletal Muscle. Circulation Research 2014 Aug 15;115(5):504-17. * - authors contributed equally.
  2. Yang JS, Lee SY, Park SY, Bai M, Alves C, Li J, Michelet X, Rowe GC, Wang Z, Rhee KY, Arany Z, Ho IC and Hsu VW. Antiquitin coordinates a global inhibition of major cellular processes in maintaining energy balance. (submitted).
  3. Thom R, Rowe GC, Jang C, Safdar A and Arany Z. Hypoxic Induction of Vascular Endothelial Growth Factor (VEGF) and Angiogenesis in Muscle by Truncated Peroxisome Proliferator- Activated Receptor Gamma Coactivator (PGC)-1alpha. JBC 2014 March 28, 289 (13) 8810-8817.
  4. Chan MC, Rowe GC, Raghuram S, Patten IS, Farrell C and Arany ZP. Post-natal induction of PGC- 1alpha protects against severe muscle dystrophy independently of utrophin. Skeletal Muscle 2014 Jan 22;4(1):2.
  1. Rowe GC, Patten IS, Zsengeller ZK, El-Khoury R, Okutsu M, Bampoh S, Koulisis N, Farrell C, Hirshman MF, Yan Z, Goodyear LJ, Rustin P and Arany Z. Disconnecting mitochondrial content from respiratory chain capacity in PGC-1 deficient skeletal muscle. Cell Reports 2013 May 30; 3(5):1449-56.
  2. Haq R, Shoag J, Andreu-Perez P, Yokoyama S, Edelman H, Rowe GC, Frederick DT, Hurley AD, Nellore A, Kung AL, Wargo JA, Song JS, Fisher DE, Arany Z, Widlund HR. Oncogenic BRAF Regulates Oxidative Metabolism via PGC1α and MITF. Cancer Cell 2013 Mar 18;23(3):302-15.
  3. Shoag J, Haq, Zhang M, Liu L, Rowe GC, Jiang A, Koulisis, Farrell C, Amos CI, Wei Q, Lee JE, Zhang J, Kupper TS, Qureshi AA, Cui R, Han J, Fisher DE, Arany Z. PGC-1 Coactivators Regulate MITF and the Tanning Response. Molecular Cell 2013 Jan 10;49(1):145-57.
  1. Rowe GC, El-Khoury R, Patten IS, Rustin P, Arany Z. PGC-1α is Dispensable for Exercise-Induced Mitochondrial Biogenesis in Skeletal Muscle. PLoS One 2012 July 24; 7(7)e41817.
  2. Rowe GC, Vialou V, Sato K, Saito H, Yin Min, Green TA, Lotinun S, Kveiborg M, Horne WC, Nestler EJ, Baron R. Energy Expenditure and Bone Formation Share a Common Sensitivity to AP-1 Transcription in the Hypothalamus. J Bone Miner Res 2012 Aug; 27(8):1649-58.
  3. Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker M, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, delMonte F, Hilfiker- Kleiner D, Karumanchi SA, Arany Z. Cardiac Angiogenic Imbalance Leads to Peripartum Cardiomyopathy. Nature 2012 May 17;485(7398):333-8.
  4. Finley L, Lee J, Souza A, Desquiret-Dumas V, Bullock K, Rowe GC, Procaccio V, Clish CB, Arany Z, Haigis MC. Skeletal muscle PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction. PNAS 2012 Feb 21; 109 (8): 2931-6.
  1. McDermott-Roe C, Ye J, Ahmed R, Sun XM, Serafín A, Ware J, Bottolo L, Muckett P, Cañas X, Zhang J, Rowe GC, Buchan R, Lu H, Braithwaite A, Mancini M, Hauton D, Martí R, García-Arumí E, Hubner N, Jacob H, Serikawa T, Zidek V, Papousek F, Kolar F, Cardona M, Ruiz-Meana M, García-Dorado D, Comella JX, Felkin LE, Barton PJ, Arany Z, Pravenec M, Petretto E, Sanchis D, Cook SA. Endonuclease G is a novel determinant of cardiac hypertrophy and mitochondrial function. Nature. 2011 October 5;478(7367):114-8.
  2. Tran M, Tam D, Bardia A, Bhasin M, Rowe GC, Kher A, Zsengeller ZK, Akhavan-Sharif MR, Khankin EV, Saintgeniez M, David S, Burstein D, Karumanchi SA, Stillman I, Arany Z, Parikh SM. PGC-1alpha promotes recovery after acute kidney injury systemic inflammation in mice. J Clin Invest. 2011 Oct 3;121(10):4003-14.
  3. Rowe GC, Jang C, Patten IS, Arany Z. PGC-1β Regulates Angiogenesis in Skeletal Muscle. AJP Endocrinology and Metabolism. 2011 Jul; 301 (1) :E155-63.
  1. Lewis G, Farrell L, Wood MJ, Martinovic M, Arany Z, Rowe GC, Souza A, Cheng S, McCabe E, Yang E, Shi X, Deo R, Roth FP, Asnani A, Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, Sabatine MS, Clish CB, Gerszten RE. Novel Metabolic Signatures of Exercise in Human Plasma. Sci Transl Med. 2010 May 26 2,(33): 33ra37.
  2. Chinsomboon J, Ruas J, Gupta R, Thom R, Shoag J, Rowe GC, Sawada N, Raghuram and Arany Z. The transcriptional coactivator PGC1a mediates exercise-induced angiogenesis in skeletal muscle. PNAS 2009 Dec 15; 106 (50):21401-6.
  3. Wu M, Hesse E, Morvan F, Zhang JP, Correa D, Rowe GC, Kiviranta R, Neff L, Philbrick WP, Horne WC and Baron R. Zfp521 antagonizes Runx2, delays osteoblast differentiation in vitro, and promotes bone formation in vivo. Bone 2009 Apr; 44(4):528-36.
  4. Rowe GC, Choi CS, Neff L, Horne WC, Shulman GI, and Baron R. Increased energy expenditure and insulin sensitivity in the high bone mass ΔFosB transgenic mice. Endocrinology 2009 Jan 150(1): 135-143.
  5. Sabakatos G*, Rowe GC* (co-first author), Kveiborg M*, Wu M, Neff L, Chiusaroli R, Philbrick WM and Baron R. The doubly truncated FosB isoform (Δ2ΔFosB) induces osteosclerosis in transgenic mice and modulates expression and phosphorylation of Smads in osteoblasts independent of AP-1 activity. J Bone Miner Res 2008 May23:584-595. * - authors contributed equally.
  6. Johnson KP, Rowe GC, Jackson BA, D'Agostino JL, Campbell PE, Guillory BO, Williams MV, Matthews QL, McKay J, Charles GM, Verret CR, Deleon M, Johnson DE, Cooke DB. Novel antineoplastic isochalcones inhibit the expression of cyclooxygenase 1,2 and EGF in human prostate cancer cell line LNCaP. Cell Mol Biol (Noisy-le-grand) 2001 Sep;47(6):1039-45.