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Jeremy Day, PhD

Jeremy Day, PhD
Assistant Professor
Department of Neurobiology
Shelby 911
1825 University Blvd
Birmingham, AL 35294
Phone: (205) 996-8960

Jeremy Day, Ph.D., is an Assistant Professor in the Department of Neurobiology at the University of Alabama at Birmingham. Dr. Day received his Ph.D. from the University of North Carolina in 2009 under Regina Carelli, and then completed a postdoctoral fellowship with David Sweatt at UAB prior to joining the faculty at UAB in 2014.


  • 2003 - B.A. Auburn University
  • 2006 - M.A. University of North Carolina at Chapel Hill
  • 2009 - Ph.D. University of North Carolina at Chapel Hill

Research Interest:

The Day Lab investigates the neurobiology of reward-related memory systems in the brain and the role of these circuits in reward function, learned motivated behaviors, and drug addiction. Our research integrates molecular, physiological, behavioral, genetic, and epigenetic tools to understand how experience alters epigenetic states in the brain, and how those changes drive future behaviors. We are currently harnessing whole-genome sequencing technology to comprehensively identify activity- and experience-dependent components of the epigenome, and are designing epigenome editing tools to establish or erase specific epigenetic marks. Our ultimate goal is to manipulate epigenetic or transcriptional patterns within selected brain regions (or even selected types of neurons) to achieve therapeutic outcomes for brain diseases. Our work is supported by research grants from NIDA, by the UAB Pittman Scholars program, by the Civitan International Research Center, and by the Evelyn McKnight Brain Institute.


  1. Day, J.J., Reed, M.N., & Newland, M.C. (2005). Neuromotor deficits in aging rats exposed to methylmercury and n-3 fatty acids. Neurotoxicology and Teratology 27(4): 629-641.
  2. Day, J.J., Wheeler, R.A., Roitman, M.F., & Carelli R.M. (2006). Nucleus accumbens neurons encode Pavlovian approach behaviors: Evidence from an autoshaping paradigm. The European Journal of Neuroscience 23(5): 1341-1351.
  3. Day, J.J. & Carelli, R.M. (2007). The nucleus accumbens and Pavlovian reward learning. The Neuroscientist 13(2): 148-159.
  4. Paletz, E.M., Day, J.J., Craig-Schmidt, M.C., & Newland, M.C. (2007). Spatial and visual
    discrimination reversals in adult and geriatric rats exposed during gestation to methylmercury and n-3 polyunsaturated fatty acids. Neurotoxicology 28(4):707-719.
  5. Day, J.J., Roitman, M.F., Wightman, R.M., & Carelli, R.M. (2007). Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens. Nature Neuroscience 10(8): 1020-1028.
  6. Day, J.J., & Carelli, R.M. (2008). Methamphetamine induces chronic corticostriatal depression: Too much of a bad thing. Neuron 58(1): 6-7.
  7. Day, J.J. (2008). ERK activation during natural reward learning: A physiological role for phasic nucleus accumbens dopamine? The Journal of Neuroscience 28(17): 4295-4297.
  8. Aragona, B.J., Cleaveland, N.A., Stuber, G.D., Day, J.J., Carelli, R.M., & Wightman, R.M. (2008). Preferential enhancement of dopamine transmission within the nucleus accumbens shell by cocaine is due to a direct increase in phasic dopamine release events. The Journal of
    Neuroscience 28(35): 8821-8831.
  9. Aragona, B.J., Day, J.J., Roitman, M.F., Cleaveland, N.A., Wightman, R.M., & Carelli, R.M. (2009). Opposite directionality in real-time dopamine transmission within the nucleus accumbens core and shell during the development of a cue-cocaine association. The European Journal of Neuroscience 30(10):1889-1899.
  10. Jones, J.L., Day, J.J., Aragona, B.J., Wheeler, R.A., Wightman, R.M., & Carelli, R.M. (2010). Basolateral amygdala modulates terminal dopamine release in the nucleus accumbens and conditioned responding. Biological Psychiatry 67(8):737-744.
  11. Day, J.J., Jones, J.L., Wightman, R.M., & Carelli, R.M. (2010). Phasic nucleus accumbens dopamine release encodes effort and delay related costs. Biological Psychiatry 68(3):306-309.
  12. Jones, J.L., Day, J.J., Wheeler, R.A., & Carelli, R.M. (2010). The basolateral amygdala differentially regulates conditioned neural responses within the nucleus accumbens core and shell. Neuroscience 169(3):1186-1198.
  13. Day, J.J., & Sweatt, J.D. (2010). DNA methylation and memory formation. Nature Neuroscience 13(11):1319-1323.
  14. Day, J.J., & Sweatt, J.D. (2011). Epigenetic modifications in neurons are essential for formation and storage of behavioral memory. Neuropsychopharmacology 36(1): 357-58.
  15. Day, J.J., Jones, J.L., & Carelli, R.M. (2011) Nucleus accumbens neurons encode predicted and ongoing reward costs. The European Journal of Neuroscience 33(2): 308-21.
  16. Sultan, F. & Day, J.J. (2011). Epigenetic mechanisms in memory and synaptic function. Epigenomics 3(2) 157-81.
  17. Day, J.J., & Sweatt, J.D. (2011). Cognitive neuroepigenetics: A role for epigenetic mechanisms in learning and memory. Neurobiology of Learning and Memory 96(1):2-12.
  18. Wheeler, R.A., Aragona, B.J., Fuhrmann, K.A., Jones, J.L., Day, J.J., Cacciapaglia, F., Wightman, R.M., & Carelli, R.M. (2011). Cocaine cues drive opposing context-dependent shifts in reward processing and emotional state. Biological Psychiatry 69(11): 1067-74.
  19. Day, J.J., & Sweatt, J.D. (2011). Epigenetic treatments for cognitive impairments. Neuropsychopharmacology doi: 10.1038/npp.2011.85.
  20. Day, J.J., & Sweatt, J.D. (2011). Epigenetic mechanisms in cognition. Neuron 70(5): 813-29.
  21. Sugam, J.A., Day, J.J., Wightman, R.M., & Carelli, R.M. (2012) Phasic nucleus accumbens dopamine encodes risk-based decision-making behavior. Biological Psychiatry 71(3):199-205.
  22. Parrish, R., Day, J.J., & Lubin, F. (2012) Direct bisulfite sequencing for examination of DNA methylation patterns with gene and nucleotide resolution from brain tissues. Current Protocols in Neuroscience Jul;Chapter 7:Unit 7.24.
  23. Porter-Stransky, K., Seiler, J., Day, J.J., & Aragona, B.J. (2013). Development of behavioral preferences for the optimal choice following unexpected reward omission is mediated by a reduction of D2-like receptor tone in the nucleus accumbens. The European Journal of Neuroscience 38(4):2572-88.
  24. Day, J.J., Childs, D., Guzman-Karlsson, M.C., Kibe, M., Moulden, J., Song, E., Tahir, A.,& Sweatt, J.D. (2013). DNA methylation regulates associative reward learning. Nature Neuroscience 16(10):1445-52.
  25. Day, J.J. (2014) New approaches to manipulating the epigenome. Dialogues in Clinical Neuroscience 16(3):345-57.
  26. Zovkic, I.B., Paulukaitis, B.S., Day, J.J., Etikala, D.M., & Sweatt, J.D. (2014). Histone H2A.Z subunit exchange controls transcription-dependent consolidation of recent and remote memory. Nature 515(7528): 582-586.
  27. Day, J.J., Kennedy, A., & Sweatt, J.D. (2015). DNA methylation and its implication and accessibility for pharmacological treatments in learning and memory. Annual Reviews in Pharmacology and Toxicology 6(55):591-611.
  28. Day, J.J., & Roberson, E.D. (2015). An epigenetic brake on genetic inheritance: DNA methylation slows effects of C9ORF72 mutations. Neurology 84(16):1616-1617.
  29. Meadows, J., Guzman-Karrlson, M.C., Holleman, C., Phillips, S., Day, J.J., Hablitz, J.J.,& Sweatt, J.D. (2015) DNA methylation regulates cell-wide glutamatergic synaptic scaling. Science Signaling 8(382): ra61.
  30. Savell, K.E., Gallus, N.V.N., Simon, R., Brown, J., Revanna, J.S., Osborn, M.K., Song, E.Y., O’Malley, J.J., Stackhouse, C.T., Norvil, A., Gowher, H., Sweatt, J.D., & Day, J.J. (2016). Extra-coding RNAs regulate neuronal DNA methylation dynamics. Nature Communications 7:
  31. Resendez, S.L., Keyes, P.C., Day, J.J., Hambro, C., Austin, C.J., Maina, F.K., Eidson, L., Porter-Stransky, K.A., Nevarez, N., McLean, J.W., Kuhnmeunch, M.A., Murphy, A.Z., Mathews, T.A., & Aragona, B.J. (2016) Dopamine and opioid systems interact within the nucleus accumbens to maintain monogamous pair bonds. eLife 5:e15325.
  32. Kennedy, A.J., Rahn, E.J., Paulukaitis, B.S., Savell, K.E., Kordasiewicz, H.B., Wang, J., Lewis, J.W., Posey, J., Strange, S.K., Guzman-Karlsson, M.C., Phillips, S.E., Decker, K., Motley, S.M., Swayze, E.E., Ecker, D.J., Michael, T.P., Day, J.J., & Sweatt, J.D. (2016) Tcf4 regulates synaptic plasticity, DNA methylation, and memory function. Cell Reports 16:1-20.