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Jianhua Zhang, PhD

Jianhua Zhang, PhD
Department of Pathology
Division of Molecular Cellular Pathology
901 19th street South
BMRII Room 534
Birmingham, AL 35294
Phone: (205) 996-5153
Full CV

Dr. Zhang received her PhD from UT Southwestern Medical Center at Dallas. Then she did a postdoctoral at the Whitehead Institute for Biomedical Studies, followed by research track assistant professor at the Univ of Cincinnati. She is currently full professor in Department of Pathology.

Research Interests:

Dr. Zhang’s research focuses on the autophagy-lysosomal pathway which plays an important role in obesity and diabetes, as well as cancer, cardiovascular, pulmonary and neurodegenerative diseases. Her group developed new concepts linking mitochondrial dysfunction, autophagy and oxidative stress in cell death and survival, including the development of novel in vitro and in vivo approaches to assessing mitochondrial function, applying an integrated approach to assess cellular response to oxidative / nitrosative / ER stress, nutrient deprivation, perturbation of glucose metabolism, mitochondrial and environmental toxins.

Web Sites:



  1. Zhang J, Liu Z-P, Jones TA, Gierasch L, Sambrook JF (1992) Mutating the charged residues in the binding site of cellular retinoic acid-binding protein (CRABP) simultaneously increases its thermostability and reduces its binding affinity.  Protein: Structure, Function, and Genetics 13:87-99 (with cover)
  2. Zhang J, Liao S-M, Jeffrey DA, Koleske AJ, Thompson CM, Chao DM, Viljoen M, van Vuuren HJJ, Young RA (1995) A kinase-cyclin pair in the RNA polymerase II holoenzyme.  Nature 374:193-196 (co-first author) (with news and views by O'Neill EM and Erin O’Shea: “Transcriptional regulation. Cyclins in initiation”)
  3. Clark PL, Liu Z-P, Zhang J, Gierasch LM (1996) Intrinsic tryptophans of CRABPI as probes of structure and folding. Prot Sci 5:1108-1117
  4. Hengartner CJ, Thompson CM, Zhang J, Chao DM, Liao S-M, Koleske AJ, Young RA (1995) Association of an activator with an RNA polymerase II holoenzyme.  Genes & Dev 9:897-910
  5. Zhang J, Liu X, Scherer DC, Van Kaer L, Wang X, Xu M (1998) Resistance to DNA fragmentation and chromatin condensation in mice lacking the DNA fragmentation factor 45.  Proc Natl Acad Sci USA 95: 12480-12485 (with commentary by Susan Cory: “Cell death throes”) PMCID:PMC22856
  6. Zhang J, Wang X, Bove K, Xu M (1999) DNA fragmentation factor 45 deficient cells are more resistant to apoptosis and exhibit different dying morphology than wild-type control cells. J Biol Chem 274:37450-37454
  7. Slane J, Lee H, Vorhees CV, Zhang J, Xu M (2000) DNA fragmentation factor 45 deficient mice exhibit enhanced spatial learning and memory compared to wild-type control mice.  Br Res 867:70-79
  8. Zhang J, Lee H, Lou DW, Boivin GP, Xu M (2000) Lack of obvious 50 kilobase pair DNA fragments in DNA fragmentation factor 45 deficient thymocytes upon activation of apoptosis. Biochem Biophy Res Comm 274:225-229
  9. Xu M, Guo Y, Vorhees CV, Zhang J (2000) Behavioral responses to cocaine and amphetamine administration in mice lacking the dopamine D1 receptor.  Br Res 852:198-207
  10. Zhang J, Xu M (2000) DNA fragmentation in apoptosis.  Cell Res 10:205-211
  11. Zhang J, Xu M (2001) Toward a molecular understanding of psychostimulant actions using genetically engineered dopamine receptor knockout mice as model systems.  J Addictive Diseases 20:7-18
  12. Yakovlev AG, Di X, Movsesyan V, Mullins PGM, Wang G, Boulares H, Zhang J, Xu M, Faden AI (2001) Presence of DNA fragmentation and lack of neuroprotective effect in DFF45 knockout mice subjected to traumatic brain injury. Mol Medicine 7:205-216  PMCID:PMC1950023
  13. Zhang J, Lee H, Agarwala A, Lou DW, Xu M (2001) DNA fragmentation factor 45 mutant mice exhibit resistance to kainic acid-induced neuronal cell death. Biochem Biophy Res Comm 285:1143-1149
  14. Hobbs JA, Cho SY, Roberts TJ, Sriram V, Zhang J, Xu M, Brutkiewicz R. (2001) Selective loss of natural killer T cells by apoptosis following infection with lymphocytic choriomeningitis virus.  J Virol 75:10746-10754  PMCID:PMC114656
  15. Zhang J, McQuade JS, Vorhees C, Xu M (2002) Hippocampal expression of c-fos is not essential for spatial learning. Synapse 46:91-99 
  16. Zhang J, Zhang D, McQuade JS, Behbehani M, Tsien J, Xu M (2002) C-fos regulates neuronal excitability and survival. Nature Genet 30:416-420
  17. Zhang J, Xu M (2002) Apoptotic DNA degradation and tissue homeostasis.  Trends Cell Biol 12:84-89
  18. Jin W, Zhang J, Lou D, Chavkin C, Xu M (2002) c-fos-deficient hippocampal CA3 pyramidal neurons exhibit both enhanced basal and kainic acid-induced excitability. Neurosci Lett 331:151-154 
  19. McQuade JS, Vorhees C, Xu M, Zhang J (2002) DNA fragmentation factor 45 knockout mice exhibit longer memory retention in the novel object recognition task compared to wild-type mice. Physiol & Beh 76:315-320 
  20. Zhang J, Xu M, Aronow B (2002) Expression profiles of 109 apoptosis pathway-related genes in 82 mouse tissues and experimental conditions. Biochem Biophy Res Comm 297:537-544
  21. Zhang D, Zhang L, Lou D, Nakabeppu Y, Zhang J, Xu M (2002) The dopamine D1 receptor is a critical mediator for cocaine-induced gene expression. J Neurochem 82:1453-1464 
  22. Pritchard LM, Logue AD, Hayes S, Welge JA, Xu M, Zhang J, Berger SP, Richtand NM (2003) 7-OH-DPAT and PD 128907 selectively activate the D3 dopamine receptor in a novel environment. Neuropsychopharmacol 28:100-107 
  23. Zheng W, Xie W, Zhang J, Strong JA, Wang L, Yu L, Xu M, Lu L (2003) Function of gamma-aminobutyric acid receptor/channel rho 1 subunits in spinal cord. J Biol Chem 278:48321-48329
  24. Zhang J, Dong M, Li L, Fan Y, Pathrie P, Dong J, Olivares-Villagom D, Lou D, Wells J, Van Kaer L, Wang X, Xu M (2003) Endonuclease G is required for early embryogenesis and normal apoptosis in mice. Proc Natl Acad Sci USA 100:15782-15787 co-corresponding author
  25. Zhang L, Lou D, Jiao H, Zhang D, Wang X, Xia Y, Zhang J, Xu M (2004) Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors. J Neurosci 24:3344-3354 
  26. Zhang J, Moseley A, Jegga AJ, Gupta A, Witte DP, Sartor M, Williams SS, Ley-Ebert C, Coolen L, Egnaczyk G, Genter MB, Lehman M, Lingrel J, Maggio J, Parysek L, Walsh R, Xu M, Aronow BJ (2004)  Neural system-enriched gene expression, relationship to biological pathways and neurological  diseases. Physiological Genomics 18, 167-183 co-corresponding author
  27. Wu Y, Zhang D, Lou D, Fan Y, Aronow B, Xu M, Zhang J (2004) c-fos regulates neuropeptide Y expression in mouse dentate gyrus. Neurosci Lett 363:6-10 
  28. Wu Y, Dong M, Toepfer NJ, Fan F, Xu M, Zhang J (2004) Role of Endonuclease G in neural excitotoxicity in mice. Neurosci Lett364:203-207 
  29. Xu M, Zhang J (2004) Molecular genetic probing of dopamine receptors in drug addiction.  Current Opinion in Drug Discovery & Development 7:703-708
  30. Rui T, Feng Q, Lei M, Peng T, Zhang J, Xu M, Abel ED, Xenocostas A, Kvietys PR (2005) Erythropoietin prevents the acute myocardial inflammatory response induced by ischemia/reperfusion induction of AP-1. Cardiovascular Research 65:719-27
  31. Zhang D, Zhang L, Zhang Q, Tang Y, Lou D, Sharp FR, Zhang J, Xu M (2005) Repeated cocaine administration induces gene expression through the dopamine D1 receptors. Neuropsychopharmacol 30:1443-1454
  32. Zhang J, Zhang L, Jiao H, Zhang Q, Zhang D, Lou D, Katz JL, Xu M (2006) c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes. J Neurosci 26:13287-13296
  33. Dong M, Wu Y, Fan Y, Xu M, Zhang J (2006) c-fos modulates brain-derived neurotrophic factor mRNA expression in mouse hippocampal CA3 and dentate gyrus neurons. Neurosci Lett 400:177-180
  34. McQuade JS, Tamashiro K, Wood G, Herman JP, McEwen BS, Sakai RR, Zhang J, Xu M (2006) Deficient hippocampal c-fos expression results in reduced anxiety and altered response to chronic stress in female mice. Neurosci Lett 403:125-30 (co-corresponding author) 
  35. McNamara RK, Logue A, Stanford K, Xu M, Zhang J, Richtand NM (2006) Dose-response analysis of locomotor activity and stereotypy in dopamine D3 receptor mutant mice following acute amphetamine. Synapse 60:399-405 PMCID:PMC1815379
  36. Li Q, Li H, Blitvich BJ, Zhang J (2007) The Aedes albopictus inhibitor of apoptosis 1 gene protects vertebrate cells from bluetongue virus-induced apoptosis. Insect Mol Biol 16:93-105
  37. Shacka J, Lu J, Xie Z, Uchiyama Y, Roth K, Zhang J (2007) Kainic acid induces early and transient autophagic stress in mouse hippocampus. Neurosci lett 414:57-60. PMCID: PMC1839881
  38. Zhou Y, Adomako-Mensah J, Yuferov V, Ho A, Zhang J, Xu M, Kreek MJ (2007) Effects of acute "binge" cocaine on mRNA levels of mu opioid receptor and neuropeptides in dopamine D1 or D3 receptor knockout mice. Synapse 61:50-9
  39. Pritchard L, Newman AH, McNamara RK, Logue AD, Taylor B, Welge JA, Xu M, Zhang J, Richtand NM (2007) The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion. Pharm Biochem Beh 86:718-26
  40. Dong M, Fan Y, Toepfer NJ, Zhang J (2007) Deficiency of DNA fragmentation factor 45 results in reduced oocyte apoptosis in response to doxorubicin. Cell Res 17:735-6
  41. Jiao H, Gao F, Lou D, Zhang J, Xu M (2007) Dopamine D1 and D3 receptors oppositely regulate NMDA- and cocaine-induced MAPK signaling via NMDA receptor phosphorylation. J Neurochem 102:840-848 
  42. Caine SB, Thomsen M, Gabriel KI, Berkowitz JS, Gold LH, Koob GF, Tonegawa S, Zhang J, Xu M (2007) Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice. J Neurosci 27:13140-13150 PMCID:PMC2747091
  43. Ness J, Harvey C, W Jason, Roth K, Carroll S, Zhang J (2008) Differential activation of c-Fos and caspase-3 in hippocampal neuron subpopulations following neonatal hypoxia-ischemia. J Neuroscience Res 86:1115-24
  44. Qiao L, Hamamichi S, Caldwell KA, Caldwell GA, Yacoubian TA, Wilson S, Xie ZL, Speake LD, Parks R, Crabtree D, Liang Q, Crimmins S, Schneider L, Uchiyama Y, Iwatsubo T, Zhou Y, Peng L, Lu YM, Standaert DG. Walls KC, Shacka JJ, Roth KA, Zhang J (2008) Lysosomal enzyme cathepsin D protects against α-synuclein aggregation and toxicity. Molecular Brain 1:17. PMCID:PMC2600785
  45. Hu XT, Nasif FJ, Zhang J, Xu M (2008) Fos regulates neuronal activity in the nucleus accumbens. Neurosci Lett 448:157-60
  46. Shacka J, Roth K, Zhang J (2008) The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy.  Frontiers in Bioscience 13:718-36
  47. Qiao L, Zhang J (2009) Inhibition of lysosomal functions reduces proteasomal activity. Neurosci Lett 456:15-19
  48. Schneider L, Zhang J (2010) Lysosomal function in macromolecular homeostasis and bioenergetics in Parkinson's disease.  Molecular Neurodegeneration 5:14.  PMCID: PMC2867960
  49. Walls KC, Ghosh AP, Franklin AL, Klocke BJ, Ballestas M, Shacka JJ, Zhang J, Roth KA (2010) Lysosome dysfunction triggers Atg7-dependent neural apoptosis. J Biol Chem 285:10497-507.  PMCID:PMC2856257
  50. Jegga A, Schneider L, Ouyang X,Zhang J (2011) Systems biology of the autophagy-lysosomal pathway.  Autophagy 7:5, 1-13.  PMCID:PMC3127210
  51. Liang Q, Ouyang X, Schneider L, Zhang J (2011) Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons.  Molecular Neurodegeneration 6:37. PMCID:PMC3164227
  52. Dranka BP, Benavides GA, Diers AR, Giordano S, Zelickson BR, Reily C, Zou L, Chatham J, Hill BG, Zhang J, Landar A, and Darley-Usmar VM (2011) Assessing bioenergetic function in response to oxidative stress by metabolic profiling.  Free Radical Biology and Medicine 51:1622-1635 PMCID:PMC3548422
  53. Schneider L, Giordano S, Zelickson BR, Johnson MA, Benavides GA, Ouyang X, Fineberg N, Darley-Usmar VM, Zhang J (2011) Differentiation of SH-SY5Y cells to a neuronal phenotype changes cellular bioenergetics and the response to oxidative stress. Free Radical Biology and Medicine 51:2007-2017. PMCID:PMC3208787
  54. Jaber N, Dou Z, Chen JS, Catanzaro J, Jiang YP, Ballou LM, Selinger E, Ouyang X, Lin R, Zhang J, Zong WX (2012) The Class III PI3K Vps34 plays an essential role in autophagy and in the heart and liver function. Proc Nat Acad Sci USA 109:2003-2008. Co-corresponding author. PMCID: PMC3277541
  55. Jaber N, Dou Z, Lin RZ, Zhang J, Zong WX (2012) Mammalian PIK3C3/VPS34: The key to autophagic processing in liver and heart. Autophagy 8:4, 707-708
  56. Higdon AN, Benavides GA, Chacko B, Ouyang X, Johnson MS, Landar A, Zhang J, Darley-Usmar VM (2012) Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy. American Journal of Physiology 302(7):H1394-409. PMCID:PMC3330785
  57. Klionsky et al (Zhang J as one of 1270 co-authors) (2012) Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy in Higher Eukaryotes. Autophagy 8:4, 445-544. PMCID:PMC3404883
  58. Giordano S, Lee J, Darley-Usmar VM, Zhang J (2012) Distinct effects of rotenone, 1-methyl-4-phenylpyridinium and 6-hydroxydopamine on cellular bioenergetics and cell death. PlosOne 7(9):e44610. PMCID:PMC3435291
  59. Cummins TD, Higdon AN, Kramer PA, Chacko B, Riggs DW, Salabei JK, Dell’Italia LJ, Zhang J, Darley-Usmar VM, Hill BG (2012) Utilization of fluorescent probes to identify subcellular proteomes and processes regulated by lipid peroxidation products. Free Radical Biology and Medicine 59:56-68. PMCID:PMC3522791
  60. Crabtree D, Zhang J (2012) Genetically engineered mouse models for Parkinson’s diseases.  Brain Research Bulletin 88:13-32. PMCID:PMC3244549
  61. Lee J, Giordano S, Zhang J (2012) Autophagy, mitochondrial and oxidative stress: cross-talk and redox signaling.  Biochemical Journal 441:523-540. PMCID:PMC3258656
  62. Hill B, Benavides G, Lancaster J, Ballinger S, Dell’Italia L, Zhang J, Darley-Usmar VM (2012) Integration of cellular bioenergetics with mitochondrial quality control and autophagy.  Biological Chemistry 393:1485-1512. PMCID:PMC3594552
  63. Mitchell T, Chacko B, Ballinger SW, Bailey SM, Zhang J, Darley-Usmar VM (2013) Convergent mechanisms for mitochondrial dysfunction in metabolic disease; insights from mitochondrial therapeutics.Biochemical Society Transactions 41:127-133 PMCID:PMC3582193
  64. Zhang J (2013) Autophagy and mitophagy in cellular damage control.  Redox Biology 1:19-23. PMCID:PMC3740586
  65. Dodson M, Darley-Usmar V, Zhang J (2013) Cellular metabolic and autophagic pathways: traffic control by redox signaling.  Free Radical Biology and Medicine 63:207-221 PMCID:PMC3729625
  66. Giordano S, Darley-Usmar V, Zhang J (2013) Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease.  Redox Biology 2:82–90. PMCID:PMC3909266
  67. Errami Y, Naura AS, Kim H, Ju J, Suzuki Y, El-Bahrawy, AH, Ghonim MA, Hemeida RA, Mansy MS, Zhang J, Xu M, Boulares AH (2013) Apoptotic DNA fragmentation may be a cooperative activity between caspase-activated DNase and the PARP-regulated DNas1L3, an ER-localized endonuclease that translocates to the nucleus during apoptosis. J Biol Chem 288(5):3460-8 PMCID:PMC3561564
  68. Errami Y, Brim H Oumouna-Benachour K, Oumouna M, Naura AS, Kim H, Ju J, Kim JG, Ashktorab H, Fallon K, Xu M, Zhang J, Del Valle L, Boulares AH (2013) ICAD deficiency in human colon cancer and predisposition to colon tumorigenesis: linkage to apoptosis resistance and genomic instability. PlosOne 8:e57871 PMCID:PMC3579889
  69. Crabtree D, Boyer-Guittaut M, Ouyang X, Fineberg N, Zhang J (2013) Dopamine and its metabolites in cathepsin D heterozygous mice before and after MPTP administration. Neuroscience Letters 538: 3-8 PMCID: PMC3645893
  70. Parekh VV, Wu L, Boyd KL, Williams, JA, Gaddy JA, Olivares-Villagomez D, Cover TL, Zong WX, Zhang J, Van Kaer L (2013) Impaired autophagy, defective T cell homeostasis and a wasting syndrome in mice with a T cell-specific deletion of Vps34. Journal of Immunity 190(10):5086-101. PMCID:PMC3646937
  71. Le Grand JN, Bon K, Fraichard A, Zhang J, Jouvenot M, Risold P-Y, Boyer-Guittaut M, Delage-Mourroux R (2013) Specific distribution of the autophagic protein GABARAPL1/GEC1 in the developing and adult mouse brain and identification of neuronal populations expressing GABARAPL1/GEC1. PlosOne 8(5):e63133 PMCID:PMC3655077
  72. Mitchell T, Johnson MS, Ouyang X, Chacko BK, Mitra K, Lei X, Gai Y, Moore DR, Barnes S, Zhang J, Koizumi A, Ramanadham S, Darley-Usmar VM (2013) Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived β-cells.  American J of Physiology 305(5):E585-99. PMCID:PMC3761167
  73. Liang Q, Benavides G, Vasilopoulos A, Gius D, Darley-Usmar V, Zhang J (2013) Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts. Biochemical Journal 454:249-257 PMCID:PMC3927421
  74. Benavides GA, Liang Q, Dodson M, Darley-Usmar V, Zhang J (2013) Inhibition of autophagy and glycolysis by nitric oxide during hypoxia-reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons. Free Radical Biology and Medicine 65:1215-1228 PMCID:PMC3859859
  75. Dodson M, Liang Q, Johnson M, Redmann M, Fineberg N, Darley-Usmar V, Zhang J (2013) Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cells. Autophagy 9:1996-2008. PMCID:PMC4028343
  76. Crabtree D, Dodson M, Ouyang X, Boyer-Guittaut M, Liang Q, Ballestas M, Fineberg N, Zhang J (2014) Overexpression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cells. J Neurochem 128:950-61.  PMCID:PMC3951679
  77. Boyer-Guittaut M, Poillet L, Liang Q, Bôle-Richard E, Ouyang X, Benavides GA, Chakrama F-Z, Fraichard A, Darley-Usmar VM, Despouy G, Jouvenot M, Delage-Mourroux R, Zhang J (2014) The role of GABARAPL1 (GEC1) in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells.  Autophagy 10:6,986-1003 PMCID:PMC4091181
  78. Chacko B, Kramer P, Ravi S, Benavides G, Mitchell T, Dranka BP, Ferrick D, Singal A, Ballinger S, Bailey SM, Hardy R, Zhang J, Zhi D, Darley-Usmar VM (2014) The Bioenergetic Health Index: A new concept in translational research.  Clinical Science 127:367-373 PMCID:PMC4202728
  79. Giordano S, Dodson M, Ravi S, Ouyang X, Redmann M, Darley-Usmar V, Zhang J (2014) Bioenergetic adaptation in response to autophagy regulators during rotenone exposure.  J Neurochem 131:625-33 PMCID:PMC4454361
  80. Sheshadri N, Catanzaro J, Bott A, Sun Y, Ullman E, Chen E, Pan J-A, Wu S, Crawford H, Zhang J, Zong WX (2014) SCCA1/SerpinB3 promotes epithelial-mesenchymal transition and oncogenic transformation via unfolded protein response and IL-6 signaling. Cancer Research 74:6318-29 PMCID:PMC4216755
  81. Levonen AL, Hill BG, Kansanen E, Zhang J, Darley-Usmar VM (2014) Redox regulation of antioxidants, autophagy and the response to stress; implications for electrophile therapeutics. Free Radical Biology and Medicine 71:196–207. PMCID:PMC4042208
  82. Redmann M, Dodson M, Boyer-Guittaut M, Darley-Usmar VM, Zhang J (2014) Mitophagy mechanisms and role in human diseases. International Journal of Biochemistry and Cell biology 53C:127-133. PMCID:PMC4111979
  83. Allison D, Antoine L, Ballinger S, Bamman M, Biga P, Darley-Usmar V, Fisher G, Gohlke J, Halade G, Hartman J, Hunter G, Messina J, Nagy T, Plaisance E, Roth K, Sandel M, Schwartz T, Smith D, Sweatt JD, Tollefsbol T, Watts S, Yang Y, Zhang J, Austad S (2014) Aging and Energetics’ ‘Top 40’ Future Research Opportunities 2010-2013.  F1000Research 12;3:219 PMCID:PMC4197746
  84. Wani W, Boyer-Guittaut M, Dodson M, Chatham J, Darley-Usmar V, Zhang J (2015) Regulation of autophagy by protein post-translational modification.  Laboratory Investigation 95:14-25. PMCID:PMC4454381
  85. Zhang J (2015) Teaching the basics of autophagy and mitophagy to redox biologists—mechanisms and experimental approaches. Redox Biology 4:242-259 PMCID:PMC4803799
  86. Dodson M, Redmann M, Rajasekaran, NS, Darley-Usmar V, Zhang J (2015) KEAP1-NRF2 signaling and autophagy in protection against oxidative and reductive proteotoxicity. Biochem Journal 469:347-355. PMCID:PMC5514546
  87. Jurkuvenaite A, Benavides GA, Komarova S, Doaran SF, Johnson M, Aggarwal S, Zhang J, Darley-Usmar VM, Matalon S (2015) Upregulation of autophagy decreases chlorine gas induced mitochondrial injury and lung inflammation. Free Radical Biology and Medicine 85:83-94 PMCID:PMC4508227
  88. Rangarajan S, Kurundkar A, Kurundkar D, Bernard K, Sanders Y, Ding Q, Antony VB, Zhang J, Zmijewski J, Thannickal VJ (2016) Novel mechanisms for the anti-fibrotic action of Nintedanib. American Journal of Respiratory Cell and Molecular Biology (AJRCMB) 54:51-59 PMCID: PMC4742925
  89. Klionsky et al (Zhang J as one of ~2000 co-authors) (2016) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.  Autophagy 12:1, 1-222 PMCID:PMC4835977
  90. Radhakrishnan RK, Narasimhan M, Shanmugam G, Devarajan A, Palaniappan S, Zhang J, Halade G, Darley-Usmar VM, Hoidal JR, Rajasekaran NS (2016) Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-Intensity exercise stress. Journal of Translational Medicine 14:86 PMCID:PMC4822244
  91. Redmann M, Darley-Usmar V, Zhang J (2016) The role of autophagy, mitophagy and lysosomal functions in modulating cellular bioenergetics and survival in the context of redox and proteotoxic damage: implications for age dependent neurodegenerative diseases. Aging and Disease 7:150-162 PMCID:PMC4809607
  92. Hjelmeland A, Zhang J (2016) Metabolic, autophagic and mitophagic activities in cancer initiation and progression. Biomedical Journal 39:98-106 PMCID:PMC5514543
  93. Wende AR, Young M, Chatham J, Zhang J, Rajasekaran NS, Darley-Usmar VM (2016) Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism. Free Radical Biology and Medicine 100:94-107PMCID:PMC5124549
  94. Aggarwal S, Mannam P, Zhang J (2016) Autophagy and mitophagy in pulmonary diseases. Am J of Physiol Lung Cell Mol Physiol 311:L433-L452. PMCID:PMC5504426
  95. Wani W, Chatham J, Darley-Usmar V, McMahon L, Zhang J (2017) O-GlcNAcylation and neurodegeneration.  Brain Res Bulletin 133:80-87 PMCID:PMC5292095
  96. Redmann M, Benavides GA, Berryhill TF, Wani WY, Ouyang X, Johnson MS, Ravi S, Barnes S, Darley-Usmar VM, Zhang J (2017) Inhibition of autophagy with bafilomycin and chloroquine decreases mitochondrial quality and bioenergetic function in primary neurons. Redox Biology 11:73-81 PMCID:PMC5124357
  97. Redmann M, Wani W, Volpicelli-Daley L, Darley-Usmar V, Zhang J (2017) Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils.  Redox Biology 11:429-437 PMCID:PMC5220183
  98. Bernard K, Logsdon NJ, Herranz VM, Benavides GA, Zhang J, Darley-Usmar VM, Thannickal VJ (2017) NADPH Oxidase 4 (Nox4) Suppresses Mitochondrial Biogenesis in Lung Fibroblasts via a Nuclear Factor Erythroid- Derived 2-like 2 (Nrf2)-Dependent Pathway. J Biol Chem 292:3029-3038 PMCID:PMC5314196
  99. Cheng S, Wani WY, Hottman DA, Jeong A, Cao D, LeBlanc KJ, Saftig P, Zhang J*, Li L* (2017) Haplodeficiency of Cathepsin Ddoes not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice.  J Neurochem 142(2):297-304 *Co-corresponding author PMCID:PMC5499660
  100. Parakh VV, Pabbisetty SK, Wu L, Sebzda E, Martinez J, Zhang J, Van Kaer L (2017) The autophagy-related protein Vps34 controls the homeostasis and function of antigen cross-presenting CD8α+ dendritic cells. Proc Nat Acad Sci USA 114(31):E6371-E6380. PMCID:PMC5547642
  101. Wani WY, Ouyang X, Benavides GA, Redmann M, Cofield JS, Shacka JJ, Darley-Usmar V, Chatham JC, Zhang J (2017) O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson's disease. Molecular Brain 10:32 PMCID:PMC5517830
  102. McGinnis GR, Tang Y, Brewer R, Brahma M, Stanley HL, Shanmugam G, Rajasekaran NS, Row GC, Frank SJ, Wende AR, Abel ED, Taegtmeyer H, Litovsky S, Darley-Usmar V, Zhang J, Chatham JC, Young ME (2017) Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart. Journal of Molecular and Cellular Cardiology 110:80-95 PMCID:PMC5586500
  103. Wu P, Yuan X, Li F, Zhang J, Zhu W, Wei M, Li J, Wang X (2017) Myocardial upregulation of cathepsin D by ischemic heart disease promotes autophagic flux and protects against cardiac remodeling and heart failure. Circ Heart Fail 10:e004044 PMCID:PMC5535800
  104. Dodson M, Benavides G, Johnson M, Redmann M, Wani WY, Ouyang X, Cofield SS, Mitra K, Darley-Usmar V, Zhang J (2017) Regulation of autophagy, mitochondrial dynamics and cellular bioenergetics by 4-hydroxynonenal in primary neurons. Autophagy 13(11):1828-1840 PMCID:PMC5788494
  105. Nelson M, Boutin M, Tse T, Lu H, Haley EM, Ouyang X, Zhang J, Auray-Blais C, Shacka JJ (2017) The lysosomal enzyme alpha-Galactosidase A is deficient in Parkinson’s disease brain in association with the pathologic accumulation of alpha-synuclein. Neurobiology of Disease 110:68-81 PMCID:PMC5747987
  106. Bernard K, Logsdon NJ, Benavides GA, Sanders Y, Zhang J, Darley-Usmar VM, Thannickal VJ (2018) Glutaminolysis is required for TGF-β1-induced myofibroblast differentiation and activation. J Biol Chem 293(4):1218-1228 PMCID:PMC5787800 (IF4)
  107. Brewer RA, Collins HE, Berry RD, Brahma MK, Tirado B, Stanley HL, Wende AR, Taegtmeyer H, Rajasekaran NS, Darley-Usmar V, Zhang J, Frank SJ, Chatham JC, Young ME (2018) Temporal partitioning of adaptive responses of the murine heart to fasting: a guide for experimental design. Life Sciences 197:30-39 PMCID:PMC5837814 (IF3.2)
  108. *Zhang J, Culp ML, Craver JG, Darley-Usmar V (2018) Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson’s disease. *corresponding author. J Neurochem 144(6):691-709, PMCID:PMC5897151 (IF4.6)
  109. Redmann M, Benavides BA, Wani WY, Berryhill TF, Ouyang X, Johnson MS, Ravi R, Mitra K, Barnes S, Darley-Usmar VM, Zhang J (2018) Methods for assessing mitochondrial quality control mechanisms and cellular consequences in cell culture. Redox Biology 17, 59-69 PMCID:PMC6006680 (IF7.2)
  110. Hough KP, Trevor JL, Strenkowski JG, Wang Y, Chacko BK, Tousif S, Chanda D, Steele C, Antony VB, Dokeland T, Ouyang X, Zhang J, Duncan SR, Thannickal VK, Darley-Usmar VM, Deshane JS (2018) Exosomal Transfer of Mitochondria from Airway Myeloid-Derived Regulatory Cells to T cells. Redox Biology 18:54-64 PMCID:PMC6031096 (IF7.2)
  111. Libby CJ, Zhang S, Benavides GA, Scott SE, Li Y, Redmann M, Tran AN, Otamias A, Darley-Usmar V, Napieralo M, Zhang J, Augelli-Szafran CE, Zhang W, Hjelmeland A (2018) Identification of Compounds That Decrease Glioblastoma Growth and Glucose Uptake in Vitro. ACS Chemical Biology 13 (8), pp 2048–2057 PMCID:PMC6425477 (IF4.6)
  112. Wright JN, Benavides GA, Johnson MS, Wani W, Ouyang X, Zou L, Collins H, Zhang J, Darley-Usmar V, Chatham JC (2019) The effect of short durations of increased cellular O-GlcNAc levels on mitochondrial function. AJP-Cell Phys (IF3.5)
  113. Hill BG, Shiva S, Ballinger B, Zhang J, Darley-Usmar V (2019) Bioenergetics and translational metabolism: Implications for physiology and precision medicine. Biol Chem (IF3)
  114. Zhang J, Chatham JC, Young M (2019) Circadian regulation of cardiac biology: rhythms that keep the heart beating.   Annual Review of Physiology (IF14) 


  1. Zhang J (2015) Autophagy Virtual collection Vol 1 Redox Biology
  2. Zhang J, Darley-Usmar V (2017) Autophagy and the redox connection: Virtual collection Vol 2 Redox Biology 11:620-621
  3. Zhang J, Van Remmen (2017) Redox biology in neurodegenerative disease – Virtual collection. Redox Biology
  4. Zhang J, Butterfield DA (2017) Oxidative stress and neurodegeneration. Brain Research Bulletin. 133:1-3

Bools and Book Chapters:

  1. Zhang J, Walsh R, Xu M (2000) Probing the role of the dopamine D1 receptor in psychostimulant addiction.  Annals of New York Academy of Sciences, SF Ali and Y Takahashi, eds. (New York: The New York Academy of Sciences) 914:13-21
  2. Zhang J, Zhang D, Xu M (2002) Identification of target genes regulated by repeated cocaine exposure through the DA D1 receptor using cDNA microarrays.  Annals of New York Academy of Sciences, SF Ali and Y Takahashi, eds. (New York: The New York Academy of Sciences). 965:1-9
  3. Xu M, Zhang J (2003) DNA fragmentation in apoptosis and tissue homeostasis.  Molecular Mechanisms of Programmed Cell Death, Y Shi, eds. (Kluwer Academic) pp 171-184
  4. Zhang J, Xu M (2003). Generating gene knockout mice for studying mechanisms underlying drug addiction.  Methods in Molecular Medicine J Wang, eds. (Humana Press) 79:351-363
  5. Gulbahar H. Beckett and Jianhua Zhang (2006) Moderation, Modesty, Creativity, and Criticalness: A Chinese-American Medical Professor Speaks. "Strangers" of the Academy Asian Women Scholars in Higher Education,G Li  and GH Beckett, eds. (Stylus Publishing, LLC) pp 233-248
  6. Jegga AG, Kong S, Zhang J, Moseley A, Gupta A, Williams SS, Genter MB, Aronow BJ (2006) Comparative genomics of tissue specific gene expression. Gene Expression and Regulation, A Current Scientific Frontiers Book, J Ma, eds. (Higher Education Press and Springer, USA) pp 393-408
  7. Zhang J, Zong W-X (2006) Cell death and transcription.  Gene Expression and Regulation, A Current Scientific Frontiers Book, J Ma, eds. (Higher Education Press and Springer, USA) pp 421-432
  8. Zhang J, Xu M (2006) Opposite regulation of cocaine-induced intracellular signaling and gene expression by dopamine D1 and D3 receptors. Annals of New York Academy of Sciences, SF Ali and Y Takahashi, eds. (New York: The New York Academy of Sciences) 1074:1-12
  9. Liang Q, Zhang J (2009) Apoptosis in neurodegenerative diseases. “Essential of Apoptosis”, 2nd edition,  XM Yin and Z Dong, eds. pp 489-504
  10. Zhang J, Darley-Usmar VM (2012) Mitochondrial dysfunction in neurodegenerative disease; protein aggregation, autophagy and oxidative stress. Mitochondrial Dysfunction in Neurodegenerative Disorders, AJ Reeve, KJ Krishnan, MR Duchen, DM Turnbull, eds. (Springer) pp95-112
  11. Zelickson BR, Ballinger S, Dell’Italia L, Zhang J, Darley-Usmar VM (2013) Reactive Oxygen and Nitrogen Species; Interactions with Mitochondria and Pathophysiology. The Encyclopedia of Biological Chemistry, WJ Lennarz, MD Lane, (eds.) Vol. 4, pp. 167-171. Waltham, MA: Academic Press.
  12. Hervouet E, Zhang J, Boyer-Guittaut (2015) ROS and epigenetics. Reactive oxygen species, pp519-533, Ahmad S (eds.) Taylor and Francis.