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Jennifer S. Pollock, Ph.D.

Jennifer S. Pollock, Ph.D.
School of Medicine, Division of Nephrology
KAUL 802A, zip 0006
Phone: (205) 975-7525
Full CV

Research Interests

Our laboratory is generally focused on the role of nitric oxide in vascular and renal function. Specifically, we have sought to determine the mechanisms of endothelial dysfunction in hypertension and diabetes as well as determining the role of nitric oxide synthase isoforms in control of renal sodium excretion and blood pressure. We have a strong effort in determining mechanisms of early life stress in adult vascular and renal dysfunction.


1975-79 B.S. Biology major, Chemistry minor, University of Evansville, Evansville, IN
1981-83 M.S. Dept of Chemistry, University of Cincinnati, Cincinnati, OH
1983-87 Ph.D. Dept of Chemistry, Biological Division, University of North Carolina at Chapel Hill, NC


  • 2014
  • 2013
  • 2012
  • 2011
  • 2010
  • pre 2010
  1. Osmond DA, Zhang S, Pollock JS, Yamamoto T, De Miguel C, Inscho EW. Clopidogrel preserves whole kidney autoregulatory behavior in ANG II-induced hypertension. Am J Physiol Renal Physiol. 306(6):F619-28, 2014.
  2. Guan Z, Singletary ST, Cook AK, Hobbs JL, Pollock JS, Inscho EW. Sphingosine-1- Phosphate Evokes Unique Segment-Specific Vasoconstriction of the Renal Microvasculature. J Am Soc Nephrol. 25: 1774-85, 2014.
  3. Jin C, O'Boyle S, Kleven DT, Pollock JS, Pollock DM, White JJ. Anti-hypertensive and anti-inflammatory actions of combined azilsartan and chlorthalidone in Dahl saltsensitive rats on a high-fat, high-salt diet. Clin Exp Pharmacol Physiol. 41: 579-88. 2014.
  4. Su S, Wang X, Kapuku GK, Treiber FA, Pollock DM, Harshfield GA, McCall WV, Pollock JS. Adverse Childhood Experiences Are Associated With Detrimental Hemodynamics and Elevated Circulating Endothelin-1 in Adolescents and Young Adults. Hypertension 64: 201-7, 2014.
  5. Loria AS, Ho DH, Pollock JS. A mechanistic look at the effects of adversity early in life on cardiovascular disease risk during adulthood. Acta Physiol (Oxf). 2014, in press.
  6. Hyndman KA, Ho DH, Sega MF, Pollock JS. Histone deacetylase 1 reduces NO production in endothelial cells via lysine deacetylation of NO synthase 3. Am J Physiol Heart Circ Physiol. 307: H803-9, 2014.
  7. Pollock JS, Ryan MJ, Samson WK, Brooks D. Water and electrolyte homeostasis brings balance to physiology. Am J Physiol: Reg Integr Comp Physiol. 307: R481-3, 2014.
  8. Heimlich JB, Speed JS, Bloom CJ, O’Connor PM, Pollock JS, Pollock DM. ET-1 increases reactive oxygen species following hypoxia and high salt diet in the mouse glomerulus. Acta Physiol 2014, in press.
  9. Jin C, Jeon Y, Kleven DT, Pollock JS, White JJ, Pollock DM. Combined endothelin A blockade and chlorthalidone treatment in a rat model of metabolic syndrome. J Pharmacol Exp Ther 2014 351: 467-4773.
  10. Xu X, Su S, Wang X, Barnes V, De Miguel C, Ownby D, Pollock JS, Snieder H, Chen W, Wang X. Obesity is Associated with more activated neutrophils in African American Male Youth. International Journal of Obesity, in press, 2014.
  1. Hyndman KA, Pollock JS. NO and the A and B of Endothelin of Sodium Homeostasis. Current Opinion in Nephrology and Hypertension, 22: 26-31, 2013.
  2. Spradley FT, Kang K-T, Pollock JS. Short-term hyper-caloric diet induces blunted aortic vasoconstriction and enhanced vasorelaxation via increased NOS3 activity and expression in Dahl salt-sensitive rats. Acta Physiologica, 207: 358-368, 2013.
  3. Loria AS, Yamamoto T, Pollock DM, Pollock JS. Early life stress induces renal dysfunction in adult male but not female rats. Am J Physiol: Regulatory, Integrative, Comparative, 304(2):R121-9, 2013.
  4. Guan Z, Giddens MI, Osmond DA, Cook AK, Hobbs JL, Zhang S, Yamamoto T, Pollock JS, Pollock DM, Inscho EW. Immunosuppression preserves renal autoregulatory function and microvascular P2X1 receptor reactivity in AngII hypertensive rats. Am J Physiol: Renal Physiol, 304: F801-7, 2013.
  5. Hyndman KA, Xue J, MacDonell, AH, Speed JS, Jin C, Pollock JS. Distinct regulation of inner medullary collecting duct NO production from mice and rats. Clinical Experimental Physiology and Pharmacology, 40: 233-9, 2013.
  6. Hyndman KA, Boesen EI, Elmarakby A, Brands MW, Huang P, Kohan DE, Pollock DM, Pollock JS. Renal collecting duct NOS1 maintains fluid-electrolyte homeostasis and blood pressure. Hypertension 62: 91-8, 2013. Cover photo highlighted this work.
  7. Loria AS, Brands MW, Pollock DM, Pollock JS. Early life stress sensitizes the renal and systemic sympathetic system in rats. Am J Physiol Renal Physiol. 305: F390-5, 2013.
  8. De Miguel C, Foster JM, Carmines PK, Pollock JS. Interaction between NO synthase and NADPH oxidase in control of sodium transport by the renal thick ascending limb during diabetes. Acta Physiol (Oxford) 209: 148-55, 2013.
  9. De Miguel C, Pollock JS. Does endoplasmic reticulum stress mediate endothelin-1- induced renal inflammation? Am J Physiol: Reg, Integ, Comp Physiol 305: R107-9, 2013.
  10. Maric-Bilkan C, Pollock JS. Data diuresis: research “to go” from the Water and Electrolyte Homeostasis Section. Am J Physiol: Reg, Integ, Comp Physiol 305: R87-8, 2013.
  1. Spradley FT, Kang K-T, Pollock DM, Pollock JS. Changing standard chow diet promotes vascular NOS dysfunction in Dahl S rats. Am J Physiol Regu Integr Compar Physiol, 302(1):R150-8, 2012.
  2. Yang J, Pollock JS, Carmines PK. NADPH oxidase and PKC contribute to increased Na transport by the thick ascending limb during type 1 diabetes. Hypertension. 2012 Feb;59(2):431-6.
  3. Kittikulsuth W, Pollock JS, Pollock DM. Loss of renal medullary endothelin B receptor function during salt deprivation is regulated by angiotensin II. Am J Physiol Renal Physiol. 303(5):F659-66, 2012.
  4. Hyndman KA, MacDonell AH, Pollock JS. Extracellular signal-regulated kinases ½ signaling pathways are not involved in endothelin regulation of mouse inner medullary collecting duct nitric oxide production. Life Sciences 91: 578-582, 2012.
  1. Saleh MA, Boesen EI, Pollock JS, Savin VJ, Pollock DM. Endothelin receptor A-specific stimulation of glomerular inflammation and injury in a streptozotocin-induced rat model of diabetes. Diabetologia, 54(4):979-88, 2011.
  2. Kang, K-T., J.C. Sullivan, F.T. Spradley, L. d’Uscio, Z. Katusic, J.S. Pollock. Antihypertensive therapy increases BH4 levels and NO/cGMP signaling in small arteries of angiotensin II-infused hypertensive rats. Am J Physiol Heart Circ Physiol., 300(3):H718- 24, 2011. Published report highlighted with an editorial commentary and podcast.
  3. Lyon-Roberts B, Strait KA, van Peursem E, Kittikulsuth W, Pollock JS, Pollock DM, Kohan DE. Flow regulation of collecting duct endothelin-1 production. Am J Physiol Renal Physiol., 300(3):F650-6, 2011.
  4. Boesen, E.I., Krishnan, K., J.S. Pollock, D.M. Pollock. ETA receptor contributes to increased T-cells and cell proliferation in the renal cortex in angiotensin II-dependent hypertension, J. Am Soc Nephrol, 22(12):2187-92, 2011.
  5. Hyndman, K.A., J. B. Musall, J. Xue, J.S. Pollock. Dynamin interacts with NOS1 in the renal collecting duct and activates NO production, Am J Physiol: Renal Physiol., 301(1):F118-24, 2011.
  6. Guan Z, Fuller BS, Yamamoto T, Cook AK, Pollock JS, Inscho EW. Pentosan Polysulfate Treatment Preserves Renal Autoregulation in Ang II-Infused Hypertensive Rats via Normalization of P2X1 Receptor Activation. Am J Physiol Renal Physiol., 298(5):F1276-84, 2011.
  7. Kittikulsuth W, Pollock JS, Pollock DM. Endothelin B receptor dependent natriuresis is impaired in angiotensin II dependent hypertension. Hypertension, 58(2):212-8, 2011.
  8. Loria AS, Kang K-T, Pollock DM, Pollock JS. Early life stress enhances angiotensin IImediated vasoconstriction by reduced endothelial NO buffering. Hypertension, 58(4):619-26, 2011.
  9. Saleh MA, Pollock JS, Pollock DM. Distinct actions of ETA selective versus combined ETA/ETB receptor antagonists in early diabetic kidney disease. J Pharmacol Exptl Therap, 338(1):263-70, 2011.
  10. Pollock JS, Pollock DM. Endothelin, nitric oxide, and reactive oxygen species in diabetic kidney disease. Contrib Nephrol.:172:149-59, 2011. 
  1. Loria, A.S., D.M. Pollock, J.S. Pollock. Early life stress sensitizes rats to angiotensin IIinduced hypertension and vascular inflammation in adult life. Hypertension, 55: 494-9, 2010.
  2. Yang, J., P.H. Lane, J.S. Pollock, P.K. Carmines. Protein kinase C-dependent NAD(P)H oxidase activation induced by type 1 diabetes in renal medullary thick ascending limb. Hypertension, 55: 468-73, 2010.
  3. Sullivan, J.C., J.L. Pardieck, K.A. Hyndman, J.S. Pollock. Renal NOS activity, expression, and localization in male and female spontaneously hypertensive rats. Am J Physiol: Reg, Integr Comp Physiol, 298: R61-9, 2010.
  4. Schneider, M.P., J.C. Sullivan, P.F. Wach, E.I. Boesen, T. Fukai, D.G. Harrison, D.M. Pollock, J.S. Pollock. Protective role of extracellular superoxide dismutase in renal ischemia/reperfusion injury. Kidney International, 78(4):374-81, 2010.
  5. Schneider, M.P., P.F. Wach, M. Durley, J.S. Pollock, D.M. Pollock. Sex differences in acute angiotensin II-mediated vasoconstriction in mice. Am J Physiol: Reg, Integr Comp Physiol, 299(3):R899-906, 2010.
  6. D’Angelo, G., A.S. Loria, D.M. Pollock, J.S. Pollock. Endothelin activation of reactive oxygen species mediates stress-induced pressor response in Dahl-salt sensitive prehypertensive rats. Hypertension, 56(2):282-9, 2010. Published report highlighted with editorial commentary.
  7. Guan, Z, Fuller, BS, Yamamoto T, Cook AK, Pollock JS, Inscho EW. Pentosan Polysulfate treatment preserves renal autoregulation in Ang II-infused hypertensive rats via normalization of P2X1 receptor activation. Am J Physiol Renal Physiol, in press, 2010.
  8. Loria, A.S., D’Angelo, G., D.M. Pollock, J.S. Pollock. Early life stress down-regulates endothelin receptor expression and enhances acute stress-mediated blood pressure responses in adult rats. Am J Physiol: Reg, Comp, Integ Physiol, 299: R185-91, 2010.
  9. Saleh MA, Boesen EI, Pollock JS, Savin VJ, Pollock DM. Endothelin-1 increases glomerular permeability and inflammation independent of blood pressure in the rat. Hypertension. 2010 Nov;56(5):942-9.
  10. Boesen EI, Pollock JS, Pollock DM. Contrasting effects of intervention with ETA and ETB receptor antagonists in hypertension induced by angiotensin II and high-salt diet. Can J Physiol Pharmacol. 2010 Aug;88(8):802-7.
  11. Boesen EI, Williams DL, Pollock JS, Pollock DM. Immunosuppression with mycophenolate mofetil attenuates the development of hypertension and albuminuria in deoxycorticosterone acetate-salt hypertensive rats. Clin Exp Pharmacol Physiol. 2010 Oct;37(10):1016-22.


  1. Sullivan, J.C., J.L. Pardieck, D. Doran, Y. Zhang, J.X. She, J.S. Pollock. Greater fractalkine expression in mesenteric arteries of female spontaneously hypertensive rats compared with males. Am J Physiol: Heart Circ Physiol, 296: H1080-1088, 2009.
  2. Sullivan, J.C., Wang, B., Boesen, E.I., D'Angelo, G., Pollock, J.S., Pollock, D.M. Novel use of ultrasound to examine regional blood flow in the mouse kidney. Am J Physiol: Renal Physiol, 297: F228-235, 2009.
  3. Foster, J.A., P. K. Carmines, J.S. Pollock. PP2B-dependent NO production in the medullary thick ascending limb during diabetes. Am J Physiol: Renal Physiol 297: F471- 80, 2009.
  4. Guan, Z., J.S. Pollock, A.K. Cook, J.L. Hobbs, E.W. Inscho. Effect of epithelial sodium channel (ENaC) blockade on the myogenic response of rat juxtamedullary afferent arterioles. Hypertension 54: 1062-1069, 2009.
  5. Yang, J., P.H. Lane, J.S. Pollock, P.K. Carmines. PKC-dependent superoxide production by the renal medullary thick ascending limb from diabetic rats. Am J Physiol: Renal Physiol 297: F1220-8, 2009.
  6. Beatty, J.S., P.F. Wach, W.D. Paulson, T.D. Merchen, D.M. Pollock, J.S. Pollock, J.J. White. Complications impair the usefulness and validity of the rat tail arteriovenous fistula model. Kidney Int. 76: 916, 2009.


  1. Sullivan, J.C., T.T. Goodchild, Z. Cai, D.M. Pollock, J.S. Pollock. ETA and ETB receptor mediated regulation of NOS1 and NOS3 isoforms in the renal inner medulla. Acta Physiol (Oxf). 191(4):329-36, 2008.
  2. Sullivan, J.C., E.J. Smart, D.M. Pollock, J.S. Pollock. Influence of salt on subcellular localization of NOS activity and expression in the renal inner medulla. Clinical Experimental Pharmacology and Physiology, 35(2):120-5, 2008.
  3. Hanevold, C., J.S. Pollock, G.A. Harshfield. Racial Differences in Microalbumin excretion in healthy adolescents. Hypertension, 51:334-8, 2008.
  4. Elmarakby, A.A., J.E. Quigley, J.D. Imig, Pollock, J.S., and Pollock, D.M. TNF-alpha inhibition reduces renal injury in DOCA-salt hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 294(1):R76-83, 2008.
  5. Pollock, J.S. and D.M. Pollock. ET and NOS1/NO signaling and regulation of sodium homeostasis. Curr Opinion in Nephrol and Hypertension, 17(1):70-5, 2008.
  6. Schneider, M.P., Ge, Y., Pollock, D.M., Pollock, J.S., and Kohan, D.E. Collecting ductderived endothelin regulates arterial pressure and Na excretion via nitric oxide. Hypertension 51:1605-10, 2008.
  7. Nakano, D., Pollock, J.S., and Pollock, D.M. Renal medullary ETB receptors produce diuresis and natriuresis via NOS1. Am J Physiol Renal Physiol. 294(5):F1205-11, 2008.
  8. Pollock, J.S. and P.K. Carmines. Editorial Commentary. Diabetic nephropathy: nitric oxide and renal medullary hypoxia. Am J Physiol Renal Physiol 294(1):F28-9, 2008.
  9. Boesen, E., Sasser, J.M., Saleh, M.A., Potter, W., Woods, M., Warner, T.D, Pollock, J.S., and Pollock, D.M. Interleukin-1{beta} but not interleukin-6 enhances renal and systemic endothelin production in vivo. Am J Physiol Renal Physiol., 295: F446-F453, 2008.


  1. Elmarakby, A., J.M. Williams, J.S. Pollock, D.M. Pollock. Synergistic actions of enalapril and tempol during chronic angiotensin II induced hypertension. Vascular Pharmacol. 46: 144-151, 2007.
  2. Sasser, J.M., J.C. Sullivan, J.L. Hobbs, T. Yamamoto, D.M. Pollock, P.K. Carmines, J.S. Pollock. Endothelin A receptor blockade reduces diabetic renal injury via an antiinflammatory mechanism. J. Am. Soc. Nephrology 18: 143-154, 2007.
  3. Kang, K-T., J.C. Sullivan, J.M. Sasser, J.D. Imig, J.S. Pollock. Novel Nitric oxide synthase dependent mechanism of vasorelaxation in small arteries from hypertensive rats. Hypertension 49: 893-901, 2007.
  4. Sullivan, J.C., J.M. Sasser, J.S. Pollock. Sexual Dimorphism in Oxidant status in spontaneously hypertensive rats. Am. J. Physiology Renal Physiol 292: R764-R768, 2007.
  5. Sullivan, J.C., L. Semprun-Prieto, E.I. Boesen, D.M. Pollock, J.S. Pollock. Sex and sex hormones influence the development of renal injury in spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 293(4):R1573-9, 2007.


  1. Jin, L., R.A. Beswick, T. Yamamoto, T. Palmer, T.A. Taylor, J.S. Pollock, D.M. Pollock, M.W. Brands, R.C. Webb. Increased reactive oxygen species contributes to kidney injury in mineralocorticoid hypertension. J. Physiol Pharmacol 57: 343-357, 2006.
  2. D’Angelo, G., J.S. Pollock, D.M. Pollock. In vivo evidence for endothelin-1-mediated attenuation of alpha-1 adrenergic stimulation. Am. J. Physiology: Heart, Circ Physiol, 290: H1251-H1258, 2006.
  3. Lee, DL, Sturgis, LC, Labazi, H, Osborne, JB, Fleming, C, Pollock, JS, Manhiani, M, Imig, JD, Brands, MW. Angiotensin II hypertension is attenuated in interleukin-6 knockout mice. Am J Physiol: Heart, Circ Physiol, 290: H935-H940, 2006.
  4. Sullivan, JC, Pollock, JS, Pollock, DM. Superoxide-Dependent Hypertension in Male and Female ETB Receptor Deficient Rats. Experimental Biology and Medicine, 231: 818-823, 2006.
  5. Pollock, JS and Carmines, PK. Editorial Commentary. NOS3 Regulation: Renal tubular epithelial cells are not simply large endothelial cells. Hypertension 47: 19-21, 2006.
  6. Sullivan, JC and Pollock, JS. Editorial Commentary. Coupled and Uncoupled NOS: Separate But Equal? Uncoupled NOS in endothelial cells is a critical pathway for intracellular signaling. Circulation Research 98: 717-719, 2006.


  1. Zhao, X., Dey A., Romanko O.P., Stepp D.W., Wang M.H., Zhou Y., Jin L., Pollock J.S., Webb R.C., Imig J.D. Decreased epoxygenase and increased epoxide hydrolase expression in the mesenteric artery of obese Zucker rats. Am. J. Physiol.: Regulatory 288: R188-R196, 2005.
  2. Lee, D.L., J.M. Sasser, J. Hobbs, A. Boriskie, D. M. Pollock, P.K. Carmines, and J. S. Pollock. Post-translational regulation of NO synthase activity in the renal medulla of diabetic rats. Am. J. Physiology: Renal 288: F82-F90, 2005.
  3. D’Angelo, G., J.S. Pollock, D.M. Pollock. Endogenous endothelin attenuates the pressor response to acute environmental stress via ETA receptors. Am. J. Physiology: Heart, 288: H1829-35, 2005.
  4. Elmarakby, A.A., E.D. Loomis, J.S. Pollock, D.M. Pollock. NADPH oxidase inhibition attenuates oxidative stress but not hypertension produced by chronic ET-1. Hypertension, 45: 283-287, 2005.
  5. Sullivan, J.C., Sasser, J.M., D.M. Pollock, J.S. Pollock. Sexual dimorphism in renal production of prostanoids in spontaneously hypertensive rats. Hypertension, 45: 406- 411, 2005.
  6. Zhao, X, Cook, AK, Field, M, Edwards, B, Zhang, S, Zhang, Z, Pollock, JS, Imig, JD, Inscho, EW. Imparied Ca2+ signaling attenuates P2X receptor-mediated vasoconstriction of afferent arterioles in angiotensin II hypertension. Hypertension 46: 562-568, 2005.
  7. Pollock, DM and Pollock, JS. Endothelin and oxidative stress in the vascular system. Curr Vasc pharmacol 3: 365-367, 2005.
  8. Loomis, E.D., J.C. Sullivan, D. Osmond, D. M. Pollock, J.S. Pollock. Endothelin mediates superoxide production and vasoconstriction through activation of NADPH oxidase and uncoupled nitric oxide synthase in the rat aorta. J. Pharmacol Exp Ther., 315: 1058-1064, 2005.


  1. Sasser, J.M., J.C. Sullivan, A. Elmarakby, B.E. Kemp, D. M. Pollock, J.S. Pollock. Reduced NOS3 phosphorylation mediates reduced NO/cGMP signaling in mesenteric arteries of DOCA-salt hypertensive rats. Hypertension 43: 1080-1085, 2004.
  2. Zhao, X., T. Yamamoto, J.W. Newman, I.H. Kim, T. Watanabe, B.D. Hammock, J. Stewart, J.S. Pollock, D.M. Pollock, J.D. Imig. Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage. J. Am. Soc. Nephrol. 15: 1244-1253, 2004.
  3. Lee, D.L., R. Leite, C. Fleming, J.S. Pollock, R.C. Webb, M.W. Brands. Hypertensive response to acute stress is attenuated in interleukin-6 knockout mice. Hypertension 44: 259-263, 2004.
  4. Sullivan, J.C., E.D. Loomis, M. Collins, J.D. Imig, E.W. Inscho, and J. S. Pollock. Agerelated alterations in NOS and oxidative stress in mesenteric arteries from male and female rats. J. Applied Physiology, 97: 1268-1274, 2004.
  5. Malhotra, S., F.A. Treiber, J. Poole, J.S. Pollock, D. Ludwig, and H. Snieder. Interactive effects of NOS3 Glu298Asp polymorphism and obesity upon hemodynamic and nitric oxide reactivity to behavioral stress. Hypertension 44: 866-871, 2004.
  6. Williams, J.M., J.S. Pollock, D.M. Pollock. Arteriolar pressure response to antioxidant, tempol, and ETB receptor blockade in rats on a high salt diet. Hypertension 44: 770- 775, 2004.
  7. Dey A., Maric C., Kaesemeyer W.H., Zaharis C.Z., Stewart J., Pollock J.S., Imig, J.D. Rofecoxib decreases renal injury in obese Zucker rats. Clin Sci 107: 561-570, 2004.
  8. Elmarakby, A.A., E.D. Loomis, J.S. Pollock, D.M. Pollock. ETA receptor blockade attenuates hypertension and decreases reactive oxygen species in ETB receptordeficient rats. J. Cardiovas. Pharm. 44: S7-S10, 2004.


  1. Taylor, T.A., J.S. Pollock, and D.M. Pollock. Down-regulation of soluble guanylyl cyclase in the inner medulla of DOCA-salt hypertensive rats. Vascular Pharmacology 40: 155-160, 2003.
  2. Taylor, T.A., C. E. Gariepy, D. M. Pollock, J.S. Pollock. Unique endothelin receptor binding in kidneys of ETB receptor deficient rats. Am. J. Physiol. 284: R674-R681, 2003.
  3. Taylor, T.A., C.E. Gariepy, D. M. Pollock, J.S. Pollock. Gender differences in ET and NOS systems in ETB receptor deficient rats: Effect of a high salt diet. Hypertension 41: 657-662, 2003.
  4. Sullivan, J.C. and J. S. Pollock. NOS 3 subcellular localization in the regulation of nitric oxide production. Acta Physiol Scand 179: 115-122, 2003.
  5. Elmarakby, A.A., Morsing, P., Pollock, J.S., and Pollock, D.M. Omapatrilat increases renal endothelin in deoxycorticosterone acetate-salt hypertensive rats. Vascular Pharmacology 40: 253-259, 2003.
  6. Treiber, F.A., P. Barbeau, G. Harshfield, H-S Kang, D. M. Pollock, J. S. Pollock, and H. Snieder. The Endothelin-1 gene lys198asn polymorphism and blood pressure reactivity. Hypertension 42: 494-499, 2003.


  1. Snieder, H., G.A. Harshfield, P. Barbeau, D.M. Pollock, J.S. Pollock, and F.A. Treiber. Dissecting the genetic architecture of the cardiovascular and renal stress response. Biological Psychology, 61:73-95, 2002.
  2. Arrigoni, F.I., Hislop, A.A., Pollock, J.S., Haworth, S.G., and Mitchell, J.A. Birth upregulates nitric oxide synthase activity in the porcine lung. Life Sciences 70: 1609- 1620, 2002.
  3. Sullivan, J.C., Pollock, D.M., and Pollock, J.S. Altered NOS 3 distribution in mesenteric arteries of hypertensive rats. Hypertension, 39: 597-602, 2002.
  4. Giulumian, A.D., M.M. Molero, V.B. Reddy, J.S. Pollock, D.M. Pollock, and L.S. Fuchs. Role of endothelin receptor binding and [Ca2+]I in contraction of coronary arteries from DOCA-salt hypertensive rats. Am. J. Physiol. Heart Circ. Physiol. 282: H1944-H1949, 2002.
  5. Sasser, J.M., J.S. Pollock, and D.M. Pollock. Renal endothelin in chronic angiotensin II hypertension. Am. J. Physiol. Integ. & Comp. Physiol. 283:R243-R248, 2002.
  6. Molero, M.M., A.D. Giulumian, V.B. Reddy, L.M. Ludwig, J.S. Pollock, D.M. Pollock, N.J. Rusch, and L.C. Fuchs. Decreased endothelin binding and [Ca2+]I signaling in microvessels of DOCA-salt hypertensive rats. J. Hypertension 20: 1799-1805, 2002.
  7. Sullivan, J.C., A.D. Giulumian, D.M.Pollock, L.C. Fuchs, and J.S. Pollock. Functional NOS 1 in rat mesenteric arterial bed. Am. J. Physiol. Heart & Circ. Physiol. 283:H658- H663, 2002.
  8. Treiber, F., G.K. Kapuku, H. Davis, J.S. Pollock, and D.M. Pollock. Plasma endothelin- 1 release during acute stress: role of ethnicity and sex. Psychosomatic Medicine 64: 707-713, 2002.
  9. Brophy, C.M., Woodrum, D.A., Pollock, J., Dickinson, M., Komalavilas, P., Cornwell, T.L., and Lincoln, T. cGMP-dependent protein kinase expression restores contractile function in cultured vascular smooth muscle cells. J. Vasc. Res. 39: 95-103, 2002.


  1. Pollock, J.S., Webb, W., Callaway, D., Sathyanarayana, O’Brien, W., and Howdieshell, T.R. Nitric oxide synthase isoform expression in a porcine model of granulation tissue formation. Surgery, 129: 341-350, 2001.
  2. Katakam, P.V.G., Pollock, J.S., Pollock, D.M., Ujhelyi, M., and Miller, A. Enhanced endothelin-1 response in small mesenteric arteries of insulin resistant rats is due to receptor over expression. Am. J. Physiol. 280: H522-H527, 2001.
  3. Laughlin, M.H., Pollock, J.S., Amann, J.F., Hollis, M.L., Woodman, C.R., and E.M. Price. Training induced increases in ecNOS expression are distributed heterogenously in the coronary arterial tree. J. Applied Physiology, 90: 501-510, 2001.
  4. Barbeau, P., Woods, K.F., Ramsey, L.T. , Litaker, M. , Pollock, D.M., Pollock, J.S. , Callahan, L.A., Kutlar, A., Mensah, G.A., and Gutin, B. Consecutive daily bouts of exercise in sickle cell anemia: effect on vasoactive mediators and inflammatory markers. Endothelium, 8: 147-155, 2001.
  5. Ishii, N., Patel, K.P., Lane, P., Taylor, T., Bian, K., Murad, F., Pollock, J.S., and Carmines, P.K. Nitric oxide synthesis and degradation in the renal cortex of rats with diabetes mellitus. J. Am. Soc. of Nephrology, 12: 1630-1639, 2001.
  6. Pollock, D.M., Derebail, V.K., Yamamoto, T., and Pollock, J.S. Combined effects of AT1 and ETA receptor antagonists, candesartan and A-127722, in DOCA-salt hypertensive rats. Gen. Pharmacology, 34: 337-342, 2000.
  7. Pollock, D.M. and Pollock, J.S. High salt intake increases the hypertension produced by chronic ETB receptor blockade in Sprague-Dawley rats. Am. J. Physiol., 281: F144- F150, 2001.
  8. Jackson, R.W., Treiber, F.A., Harshfield, G.A., Waller, J.L., Pollock, J.S., and Pollock, D.M. Urinary excretion of vasoactive factors are correlated to sodium excretion. Am. J.
    Hypertension, 14: 1003-1006, 2001.
  9. Perry, M.B., M.M. Molero, A.D. Giulumian, P.V. Katakam, J.S. Pollock, D.M. Pollock, and L.C. Fuchs. ETB receptor deficient rats exhibit reduced contraction to ET-1 despite an increase in ETA receptors. Am. J. Physiol. Heart Circ. Physiol. 281: H2680-H2686, 2001.
  10. Howdieshell, T.R., Callaway, D., Webb, W.L., Gaines, M.D., Procter, C.D., Sathyanarayana, Pollock, J.S., Brock, T., and McNeil, P.L. Antibody neutralization of vascular endothelial growth factor inhibits wound granulation tissue formation. J. Surgical Research 96: 173-182, 2001.


  1. Brophy, C.M., Knoepp, L., Xin, J., and Pollock, J.S. Functional expression of NOS 1 in vascular smooth muscle. Am. J. Physiol., 278: H991-H997, 2000.
  2. Treiber, F.A., Jackson, R.W., Davis, H., Pollock, J.S., Kapuku, G., Mensah, G.A., and Pollock, D.M. Racial differences in endothelin-1 at rest and in response to acute stress in adolescent males. Hypertension, 35: 722-725, 2000.
  3. Cai,Z., Xin, J., Pollock, D.M., and Pollock, J.S. Shear stress-mediated nitric oxide production in inner medullary collecting duct cells. Am. J. Physiol. 279: F270, 2000.
  4. Pollock, D.M., Allcock, G.H., Krishnan, A., Dayton, D.B., and Pollock, J.S. Upregulation of endothelin B receptors in kidneys of DOCA-salt hypertensive rats. Am. J. Physiol., 278: F279-F286, 2000.


  1. Allcock, G.H., Hukkanen, M., Polak, J.M., Pollock, J.S., and Pollock, D.M. Increased nitric oxide synthase 3 expression in kidneys of DOCA-salt hypertensive rats. J. Am. Soc. of Nephrol., 10: 2283-2289, 1999.


  1. Pollock, D.M., J.S. Polakowski, T.J. Opgenorth, and J.S. Pollock. Role of ETA receptors in the hypertension produced by 4-day L-NAME and cyclosporine treatment. Eur. J. Pharm., 346: 43-50, 1998.
  2. Mason, N., Springall, D., Burke, M., Pollock, J.S., Mikhail, M., Yacoub, M., and Polak, J.M. High expression of endothelial nitric oxide synthase in plexiform lesions of pulmonary hypertension. J. Pathology 185: 313-318, 1998.


  1. Wallerath, T., Gath, I., Aulitzky, W.E., Pollock, J.S., Kleinert, H., and Förstermann, U. Identification of the NO synthase isoforms expressed in human neutrophil granulocytes, megakaryocytes, and platelets. Thrombosis and Haemostasis 77: 163-167, 1997.
  2. Gosepath, K., Gath, I., Maurer, J., Pollock, J.S., Amedee, R., Förstermann, U., and Mann, W. Characterization of nitric oxide synthase isoforms expressed in different structures of the guinea pig cochlea. Brain Research 747: 26-33, 1997.
  3. Hislop, A.A., Springall, D.R., Oliveira, H., Pollock, J.S., Polak, J.M., Haworth, S.G. Endothelial nitric oxide synthase in hypoxic newborn porcine pulmonary vessels. Archives of Diseases in Childhood Fetal Neonatal Ed 77: F16-22, 1997.
  4. Helfrich, M.H., Evans, D.E., Grabowski, P.S., Pollock, J.S., Ohshima, H., and Ralston, S.H. Expression of nitric oxide synthase isoforms in bone and bone cell cultures. J. Bone and Mineral Research 12: 1108-15, 1997.
  5. Wilcox, J.N., Subramanian, R.R., Sundell, C.L., Pollock, J.S., Harrison, D.G., and Marsden, P.A. Expression of nitric oxide synthase in normal and atherosclerotic vessels. Atherosclerosis, Thrombosis, and Vascular Biology 17: 2479-2488, 1997.


  1. Hulkower, K.I., Pollock, J.S., Walsh, R.E., Otis, E.R., Brooks, C.D.W., and Bell, R.E. Leukotrienes do not regulate nitric oxide production in RAW 264.7 macrophages. Prostaglandins, Leukotrienes, and Essential Fatty Acids 55: 145-149, 1996.
  2. Myers, P.R., Webel, R., Thondapu, V., Xu, X., Amann, J., Tanner, M., Jenkins, J., Pollock, J.S., Laughlin, M. Restenosis is associated with decreased coronary artery nitric oxide synthase. International J. Cardiology 55: 183-191, 1996.
  3. Torihashi, S., Horowitz, B., Pollock, J.S., Ward, S., Xue, C., Kobayashi, S., and Sanders, K.M. Expression of nitric oxide synthase in mucosal coils of the canine colon. Histochemistry and Cell Biology 105: 33-41, 1996.


  1. Eis, A.L., Brockman, D.E., Pollock, J.S., and Myatt, L. Immunohistochemical localization of endothelial nitric oxide synthase in human villous and extravillous trophoblast populations and expression during syncytiotrophoblast formation in vitro. Placenta 16: 113-126, 1995.
  2. Pollock, J.S., Förstermann, U., Tracey, W.R., and Nakane, M. Nitric oxide synthase isoform antibodies. Histochemical Journal, 27: 738-744, 1995.
  3. Xu, X-P., Pollock, J.S., Tanner, M.A., and Myers, P.R. Hypoxia activates nitric oxide synthase and stimulates nitric oxide production in porcine coronary resistance arteriolar endothelial cells. Cardiovascular Research 30: 841-847, 1995.
  4. Ghabour, M.S., Eis, A.L.W., Brockman, D.E., Pollock, J.S., and Myatt, L. Immunohistochemical characterization of placental nitric oxide synthase expression in preeclampsia. Am. J. Ob. & Gyn. 173: 687-694, 1995.
  5. Hislop, A.A., Buttery, L.K.D., Springall, D.R., Pollock, J.S., Polak, J.M., and Haworth, S.G. Abundance of endothelial nitric oxide synthase in newborn intrapulmonary arteries. Arch. Dis. Childhood Fetal & Neonatal Ed 73: F17-21, 1995.
  6. Sessa, W.C., Garcia-Cardena, G., Liu, J., Keh, A., Pollock, J.S., Bradley, J., Thiru, S., Braverman, I.M., and Desai, K.M. The golgi association of endothelial nitric oxide synthase is necessary for the efficient synthesis of nitric oxide. J. Biol. Chem. 270: 17641-17644, 1995.
  7. Nakane, M., Pollock, J.S., Klinghofer, V., Marsden, P.A., Hokari, A., Ogura, T., Esumi, H., and Carter, G.W. Expression of three isoforms of human nitric oxide synthase in baculovirus-insect cells. Biochem. Biophys. Res. Comm. 206: 511-517, 1995.
  8. Nakane, M., Klinghofer, V., Kuk, J.E., Donnelly, J.L., Budzik, G.P., Pollock, J.S., Basha, F., and Carter, G.W. Novel potent and selective inhibitors for inducible nitric oxide synthase. Mol. Pharm. 47: 831-834, 1995.
  9. Kasuya, H., Weir, B.K., Nakane, M., Pollock, J.S., Johns, L., Marton, L.S., and Stefansson, K. Nitric oxide synthase and guanylate cyclase levels in canine basilar artery after subarachnoid hemorrhage. J. Neurosurgery 82: 250-255, 1995.


  1. Tracey, W.R., Pollock, J.S., Murad, F., Nakane, M., and Förstermann, U. Identification of a type III (endothelial-like) particulate nitric oxide synthase in LLC-PK1 kidney tubular epithelial cells. Am. J. Physiol. 266 (Cell Physiology 35): C22-C28, 1994.
  2. Halbower, A.C., Tudor, R.M., Pollock, J.S., Förstermann, U., and Abman, S.H. Maturation-related changes in endothelial nitric oxide synthase immunolocalization in the developing ovine pulmonary circulation. Am. J. Physiol., 267 (Lung Cell. Mol. Physiol. 11): L585-L591, 1994.
  3. Tracey, W.R., Xue, C., Klinghofer, V., Barlow, J., Pollock, J.S., Förstermann, U., and Johns, R.A. Immunochemical detection of inducible NO synthase in human lung. Am. J. Physiol. 266 (Lung Cell. Mol. Physiol. 10): L722-L727, 1994.
  4. Dorheim, M-A., Tracey, W.R., b., and Grammas, P. Nitric oxide is elevated in alzheimer's brain microvessels. Biochem. Biophys. Res. Comm. 205: 659-665, 1994.
  5. Förstermann, U., Closs, E.I., Pollock, J.S., Nakane, M., Schwarz, P., Gath, I., and Kleinert, H. Nitric Oxide Synthase Isozymes: Characterization, purification, molecular cloning, and functions. Hypertension 23: 1121-1131, 1994.
  6. Monaco, L., Pellegatta, F., Tagliabue, R., Lu, Yan, Benatti, L., Isacchi, A., Pollock. J.S., Chierchia, S.L., Soria, M.R., and Vidal, M.J. Endothelioma cells express and secrete endothelin-1 and inhibit platelet aggregation through nitric oxide formation. Endothelium 2: 125-137, 1994.
  7. Zhang, Z.G., Chopp, M., Gautam, S., Zaloga, C., Zhang, R.L., Schmidt, H.H.H.W., Pollock, J.S., and Forstermann, U. Upregulation of neuronal nitric oxide synthase and mRNA, and selective sparing of nitric oxide synthase-containing neurons after focal cerebral ischemia in rat. Brain Research 654: 85-95, 1994.


  1. Nakane, M., Schmidt, H.H.H.W., Pollock, J.S., Förstermann, U., and Murad, F. Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle. FEBS Lett. 316: 175-180, 1993.
  2. Förstermann, U., Pollock, J.S., and Nakane, M. Nitric oxide synthases in the cardiovascular system. Trends in Cardiovascular Medicine 3: 104-110, 1993.
  3. Matsumoto, T., Pollock, J.S., Nakane, M., and Förstermann, U. Developmental changes of cytosolic and particulate nitric oxide synthase in the rat brain. Developmental Brain Res. 73: 199-203, 1993.
  4. Sessa, W.C., Harrison, J.K., Luthin, D.R., Pollock, J.S., and Lynch, K.R. Genomic analysis and tissue expression reveal distinct genes encoding endothelial and brain nitric oxide synthases. Hypertension 21: 934-938, 1993.
  5. Matsumoto, T., Nakane, M., Pollock, J.S., Kuk, J.E., and Förstermann, U. A correlation between soluble brain nitric oxide synthase and NADPH-diaphorase activity is only seen after exposure of the tissue to fixative. Neuroscience Lett. 155: 61-64, 1993.
  6. Tracey, W.R., Nakane, M., Pollock, J.S., and Förstermann, U. Nitric oxide synthases in neuronal cells, macrophages, and endothelium are NADPH diaphorases, but represent only a fraction of total cellular NADPH diaphorase activity. Biochem. Biophys. Res. Comm. 195: 1035-1040, 1993.
  7. Myatt, L., Brockman, D.E., Langdon, G., and Pollock, J.S. Constitutive calciumdependent isoform of nitric oxide synthase in the placental villous vascular tree. Placenta 14: 373-383, 1993.
  8. Pollock, J.S., Nakane, M., Buttery, L.D., Springall, D.S., Polak, J.M., Förstermann, U., and Murad, F. Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies. Am. J. Physiol. 265 (Cell Physiology 34): C1379- C1387, 1993.
  9. Myatt, L., Brockman, D.E., Eis, A.L.W., and Pollock, J.S. Immunohistochemical localization of nitric oxide synthase in the human placenta. Placenta 14: 487-495, 1993.
  10. Pollock, J.S., Werner, E.R., Mitchell, J.A., and Förstermann, U. Particulate endothelial nitric oxide synthase: Requirement and content of tetrahydrobiopterin, FAD, and FMN. Endothelium 1: 147-152, 1993.
  11. Zhang, Z.G., Chopp, M., Zaloga, C., Pollock, J.S., and Förstermann, U. Cerebral endothelial nitric oxide synthase expression after focal cerebral ischemia in rats. Stroke 2016-2021, 1993.


  1. Murad, F., Förstermann, U., Nakane, M., Schmidt, H., Pollock, J., Sheng, H., Matsumoto, T., Warner, T., Mitchell, J., Tracey, R., and Buechler, W. The nitric oxidecyclic GMP signal transduction pathway in vascular smooth muscle preparations and other tissues. Japanese J. Pharmacol. 58 (Suppl. 2): 150P-157P, 1992.
  2. Mitchell, J.A., Kohlhaas, K.L., Matsumoto, T., Pollock, J.S., Förstermann, U., Warner, T.D., Schmidt, H.H.W. and Murad, F. Induction of NADPH-dependent diaphorase and nitirc oxide synthase activity in aortic smooth muscle and cultured macrophages. Mol. Pharmacol. 41: 1163-1168, 1992.
  3. Sheng, H., Schmidt, H.H.H.W., Nakane, M., Mitchell, J.A., Pollock, J.S., Förstermann, U. and Murad, F. Characterization and localization of nitric oxide synthase in nonadrenergic non-cholinergic nerves from bovine retactor penis muscle Br. J. Pharmacol. 106: 768-773, 1992.
  4. Schmidt, H.H.H.W., Gagne, G.D., Nakane, M., Pollock, J.S., Miller, M.F., and Murad, F. Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions for nitrinergic signal transduction. Jour. Histochem. and Cytochem. 40: 1439- 1456, 1992.
  5. Mitchell, J.A., Kohlhaas, K.L., Matsumoto, T., Warner, T.D., Pollock, J.S., Förstermann, U., Schmidt, H.H.H.W., and Murad, F. NO synthase activity in the lung is speciesdependent. Br. J. Pharmacol. 107 (Suppl.): 84P, 1992.
  6. Pollock, J.S., Klinghofer, V., Förstermann, U., and Murad, F. Endothelial nitric oxide synthase is myristylated. FEBS Lett. 309: 402-404, 1992.
  7. Pollock, J.S., Nakane, M., Förstermann, U. and Murad, F. Particulate and soluble bovine endothelial nitric oxide synthases are structurally similar proteins yet different from soluble brain nitirc oxide synthase. J. Cardiovascular Pharm. 20 (Suppl. 12): S50- S53, 1992.


  1. Förstermann, U., Schmidt, H.H.H.W., Pollock, J.S., Sheng, H., Mitchell, J.A., Warner, T.D., Nakane, M., and Murad, F. Isoforms of nitric oxide synthase. Characterization and purification from different cell types. Biochem. Pharmacol. 42: 1849-1857, 1991.
  2. Schmidt, H.H.H.W., Pollock, J.S., Nakane, M., Gorsky, L.D., Förstermann, U., and Murad, F. Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase. Proc. Natl. Acad. Sci. USA 88: 365-369, 1991.
  3. Förstermann, U., Pollock, J.S., Schmidt, H.H.H.W., Heller, M., and Murad, F. Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells. Proc. Natl. Acad. Sci. USA 88: 1788-1792, 1991.
  4. Mitchell, J.A., Förstermann, U., Warner, T.D., Pollock, J.S., Schmidt, H.H.H.W., Heller, M., and Murad, F. Endothelial cells have a particulate enzyme system responsible for EDRF formation: Measurement by vascular relaxation. Biochem. Biophys. Res. Comm. 176: 1417-1423, 1991.
  5. Förstermann, U., Schmidt, H.H.H.W., Pollock, J.S., Heller, M., and Murad, F. Enzymes synthesizing guanylate cyclase-activating factors in endothelial cells, neuroblastoma cells, and rat brain. J. Cardiovas. Pharmacol. 17(Suppl 3): S57-S64, 1991.
  6. Pollock, J.S., Förstermann, U., Mitchell, J.A., Warner, T.D., Schmidt, H.H.H.W., Nakane, M., and Murad, F. Purification and characterization of particulate endotheliumderived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proc. Natl. Acad. Sci. USA 88: 10480-10484, 1991.


  1. Förstermann, U., Gorsky, L.D., Pollock, J.S., Schmidt, H.H.H.W., Heller, M., and Murad, F. Regional distribution of EDRF/NO-synthesizing enzyme(s) in rat brain. Biochem. Biophys. Res. Comm. 168: 727-732, 1990.
  2. Förstermann, U., Gorsky, L.D., Pollock, J.S., Ishii, K., Schmidt, H.H.H.W., Heller, M., and Murad, F. Hormone-induced biosynthesis of endothelium-derived relaxing factor/nitric oxide-like material in N1E-115 neuroblastoma cells requires calcium and calmodulin. Mol. Pharmacol. 38: 7-13, 1990.


  1. Pollock, J.S., Shepard, A.J., Weber, D.J., Olson, D.L., Pedersen, L.G., Klapper, D.G., and Hiskey, R.G. Phospholipid binding characteristics of the prothrombin Gla domain, residues 1-45. J. Biol. Chem. 263: 14216-14223, 1988.
  2. Weber, D.J., Pollock, J.S., Pedersen, L.G., and Hiskey, R.G. The determination of a calcium-dependent binding constant of the bovine prothrombin Gla domain (amino acids 1-45) to phospholipid vesicles. Biochem. Biophys. Res. Comm. 155: 230-235, 1988.
  3. Zapata, G.A., Berkowitz, P., Noyes, C.M., Pollock, J.S., Deerfield, D.W., Pedersen, L.G., and Hiskey, R.G. Chemical modification of bovine prothrombin fragment 1 in the presence of Tb3+ ions. Sequence studies on 3-MGlu F-1. J. Biol. Chem. 263: 8150- 8156, 1988.