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Lufang Zhou, PhD

Lufang Zhou, PhD
Assistant Professor
Department of Medicine
Division of Cardiovascular Disease
Zeigler Building, Room 306
1530 3rd Avenue South
Birmingham, Alabama 35294-0006
Phone: 205-975-3764

Research/Clinical Interest

  • Pathogenesis of calcium overload mediated cardiac arrhythmias
  • Interactions between mitochondrial energetics and calcium handling in normal and diseased heart
  • Mitochondrial dysfunction, oxidative stress and heart failure
  • Multiscale modeling of cardiac disease
  • High resolution live cell imaging

Selected Publications

  1. Zhou L and O’Rourke B. "Cardiac mitochondrial network excitability: insights from computational
    analysis". Am J Physiol Heart Circ Physiol 302: H2178-89, 2012.
    PMID: 22427517
  2. Aon MA, Cortassa S, Akar FG, Brown DA, Zhou L and O’Rourke B. “From mitochondrial dynamics to arrhythmias.” Int J Biochem Cell Biol. 41(10): 1940-1948, 2009. PMID: 18603526
  3. Zhou L, Cortassa S, Wei AC, Aon MA, Winslow R and O’Rourke B. “Modeling cardiac action potential shortening driven by ROS-Induced mitochondrial oscillations in guinea pig cardiomyocyte.” Biophysical J, 97(7):1843-1853, 2009. PMID: 19804714 
  4. Zhou L, Aon M, Tabish A, Cortassa S, Winslow R and O’Rourke B. “A reaction-diffusion model of ROS-induced ROS release in a mitochondrial network.” PLoS Comput Biol 6(1): e1000657. doi:10.1371/journal.pcbi.1000657, 2010. PMID: 20126535
  5. Zhou L, Aon MA, Ting Liu, and O’Rourke B. “Dynamic modulation of Ca2+ sparks by mitochondrial oscillations in isolated guinea pig cardiomyocytes under oxidative stress.” J Mol Cell Cardiol. 2011 Nov;51(5):632-9 (Highlighted Article). PMID: 21645518
  6. Zhou L, Cabrera ME, Huang H, Yuan CL, Monika DK, Sharma N, Bian F, and Stanley WC. “Parallel activation of mitochondrial oxidative metabolism with increased cardiac energy expenditure is not dependent on fatty acid oxidation.” J Physiol (Lond), 579, 811-21, 2007. PMID: 17185335
  7. Zhou L, Huang H, McElfresh TA, Prosdocimo T, and Stanley WC. “Impact of anaerobic glycolysis and oxidative substrate selection on contractile function and mechanical efficiency during moderate severity ischemia.” Am J Physiol Heart Circ Physiol, 295(3):H939-45, 2008 PMID: 18660443