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Michael S. Saag, MD

Michael S. Saag, MD
Division of Infectious Diseases
BBRB 256
1720 2nd Ave S
Birmingham, AL 35294-2170
Phone: (205) 934-7349 or (205) 934-1917

Professional training

Medical School: University of Louisville
Residency: Internal Medicine, UAB
Fellowship: Infectious Diseases, UAB

Research interests

Dr. Saag focuses on studies of HIV and HCV clinical, translational, and outcomes research. He has published over 300 articles in peer reviewed journals, including the genetic evolution of HIV in vivo (Nature, 1988), the first description of the use of viral load in clinical practice (Science, 1993), the first description of the rapid dynamics of viral replication (Nature, 1995), the first guidelines for use of viral load in practice (Nature Medicine, 1996), the first proof of concept of fusion inhibition as a therapeutic option (Nature Medicine, 1998), and directed the ‘first-in- patient’ studies of 7 of the 25 antiretroviral drugs currently on the market (including indinavir, efavirenz, abacavir, and enfuvirtide). During his Fellowship at UAB, Dr. Saag conceived the concept of a comprehensive HIV outpatient (1917) clinic dedicated to the provision of comprehensive patient care in conjunction with the conduct of high quality clinic trials, basic science, and clinical outcomes research. Within the clinic structure, he established a clinical trials unit, a data management center, and a Clinical Specimen Repository designed to support the activities of the newly established Center for AIDS Research at UAB. In essence, the clinic became a “hub” for the clinical, basic science, and behavioral science investigators within the Center by creating a dynamic interface between the patients and the investigators. He is the Principal Investigator of the CFAR Network of Integrated Clinical Systems (CNICS), a national resource of merged clinical data and specimens from 8 CFARs in the US (

Dr. Saag is Co-Editor of the textbook AIDS Therapy (Churchill Livingston, now in its 3rd edition) and currently serves as an Editor of the Sanford Guide for Antimicrobial Agents and the Sanford HIV Guide. He recently served on the Board of Directors of the American Board of Internal Medicine (and as Chair of the Infectious Disease Subspecialty Board) and has served recently on the NIH Office of AIDS Research Advisory Council. Dr. Saag currently serves on the International AIDS Society-USA Board of Directors and is a member of the HHS Guidelines Panel on Antiretroviral Therapy. In December 2010, he was awarded the President’s Medal of UAB, the highest honor given at this institution.