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Matthew Stoll, PhD

Matthew Stoll, PhD
 
Associate Professor
Department of Pediatrics
Division of Pediatric Rheumatology
1601 4th Ave South
Birmingham, AL 35233
Phone: (205) 638-9438
E-mail: mstoll@peds.uab.edu
Full CV

Dr. Stoll is a pediatric rheumatologist who earned his MD and PhD at Upstate Medical University (Syracuse, NY) in 2001, followed by completion of residency in pediatrics at the Long Island Jewish Medical Center in 2004 and fellowship in pediatric rheumatology at the Childrens Hospital Boston in 2007. At the completion of his fellowship, he took a staff position at the University of Texas at Southwestern Medical Center (Dallas, TX), where he earned an MSCS degree. In 2011, he moved to the University of Alabama at Birmingham and was promoted to the level of Associate Professor in October of 2014. During his fellowship, Dr. Stoll developed an interest in the clinical epidemiology of spondyloarthritis, publishing on age-based subgroups of juvenile psoriatic arthritis as well as risk factors for sacroiliitis in patients with pediatric spondyloarthritis. He subsequently turned his attention to the links between spondyloarthritis and inflammatory bowel disease and reported on use of fecal calprotectin as well as intestinal MRI to identify sub-clinical intestinal inflammation in children with spondyloarthritis. His current work focuses on the role of the intestinal microbiota in the pathogenesis of spondyloarthritis, as well as on therapeutic dietary manipulations. He is currently studying the ability of dietary manipulation to impact the microbiota and disease severity in a mouse model of arthritis.

Education:

  • 1994 - B.A. (Molec. Biology & Biochem.) Wesleyan University (Middletown, CT)
  • 2001 - M.D., Ph.D. (Immunology) SUNY Upstate Medical University (Syracuse, NY)
  • 2011 - M.S.C.S. UT Southwestern Medical Center (Dallas, TX)

Publications:

  1. Stoll M, Gavalchin J. Systemic lupus erythematosus—messages from experimental models. Rheumatology 2000; 39:18-27.
  2. Price K, Knupp CJ, Tatum AH, Jiang F, Stoll ML, Gavalchin J. Molecular identification of pathogenic IdLNF1 autoantibody idiotypes derived from the (NZB x SWR)F1 model for systemic lupus erythematosus. Journal of Autoimmunity 2002; 19: 87-101.
  3. Stoll ML, Listman JA. Nephrolithiasis in a neonate with transient renal wasting of calcium and magnesium. Pediatric Nephrology 2002; 17: 386-389.
  4. Brown K, Ratner M, Stoll M. Pheochromocytoma unmasked by imipramine in an 8-year old girl. Pediatric Emergency Care 2003; 19: 174-177.
  5. Stoll ML, Gauthier BG, Vergara M, Ramek J, Frank R, Trachtman H. Efficacy of losartan in the treatment of erythrocytosis in a young adult with CRF. Pediatric Nephrology 2004; 19: 120-121.
  6. Stoll ML, Rubin LG. Incidence of occult bacteremia among highly febrile young children presenting to a children’s hospital emergency department or urgent care center in the era of the pneumococcal conjugate vaccine. Archives of Pediatric and Adolescent Medicine 2004; 158: 671-675.
  7. Stoll ML, Zurakowski D, Nigrovic LE, Nichols DP, Sundel RP, Nigrovic PA. Patients with juvenile psoriatic arthritis comprise two distinct populations. Arthritis and Rheumatism 2006; 54: 3564-3572.
  8. Stoll ML, Nigrovic PA. Subpopulations within juvenile psoriatic arthritis: a review of the literature. Clinical and Developmental Immunology 2006; 13): 377-380.
  9. Stoll ML, Price KD, Silvin CJ, Jiang F, Gavalchin J. Immunization with peptides derived from the idiotypic region of lupus-associated autoantibodies delays the development of lupus nephritis in the (SWR x NZB)F1 murine model. Journal of Autoimmunity 2007; 29: 30-37.
  10. Stoll ML, Gotte AC. Biological therapies for the treatment of juvenile idiopathic arthritis: lessons from adult and pediatric experiences. Biologics: Targets and Therapies 2008; 2: 229-252.
  11. Stoll ML, Lio P, Sundel RP, Nigrovic PA. Comparison of Vancouver and International League of Associations for Rheumatology classification criteria for juvenile psoriatic arthritis. Arthritis Care and Research 2008; 59: 51-58.
  12. Stoll ML, Solomon DH, Batra KL, Simard JF, Karlson EW, Dellaripa PF, Weinblatt ME, Glass R, Shadick NA. TNFα inhibitors may improve asthma symptoms: a case series of 12 patients with rheumatoid arthritis and asthma. Journal of Clinical Rheumatology 2009; 15: 198-200.
  13. Simard JF, Stoll ML, Shadick NA, Karlson EW, Solomon DH. Validity of self-report of infections in a longitudinal cohort of patients with rheumatoid arthritis differs by source of report and infection severity. Journal of Clinical Epidemiology 2010; 63: 1358-1362.
  14. Stoll ML, Bhore R, Dempsey-Robertson M, Punaro M. Spondyloarthritis in a pediatric population: risk factors for sacroiliitis. Journal of Rheumatology 2010; 37: 2402-2408.
  15. Stoll ML, Nigrovic PA, Gotte AC, Punaro M. Clinical comparison of early-onset psoriatic and non-psoriatic oligoarticular juvenile idiopathic arthritis. Clinical and Experimental Rheumatology 2011; 29: 582-588.
  16. Stoll ML. Interactions of the innate and adaptive arms of the immune system in the pathogenesis of spondyloarthritis. Clinical and Experimental Rheumatology 2011; 29: 322-330.
  17. Stoll ML, Li Q, Zhou J, Punaro M, Olsen N. Elevated IgG autoantibody production in oligoarticular juvenile idiopathic arthritis may predict a refractory course. Clinical and Experimental Rheumatology 2011; 29: 736-742.
  18. Stoll ML, Patel AS, Punaro M. Fecal calprotectin in children with the enthesitis-related arthritis subtype of juvenile idiopathic arthritis. Journal of Rheumatology 2011; 38: 2274-2275.
  19. Stoll ML, Punaro M. Psoriatic juvenile idiopathic arthritis: a tale of two subgroups. Current Opinion in Rheumatology 2011; 23: 437-443.
  20. Stoll ML, Patel AS, Punaro M, Dempsey-Robertson M. MR enterography to evaluate sub-clinical intestinal inflammation in children with spondyloarthritis. Pediatric Rheumatology 2012; 10: 6.
  21. Feng F, Silvin C, Fiore N, Stoll M, Shanley P, Silverstone AE, and Gavalchin J. 17β-Estradiol (E-2) administration to male (NZB x SWR)F1 mice results in increased IdLNF1-reactive memory T-lymphocytes and accelerated glomerulonephritis. Lupus, 2012; 21: 288-301.
  22. Stoll ML, Patel AS, Christadoss ML, Punaro M, Olsen NJ. IgA transglutaminase levels in children with juvenile idiopathic arthritis. Annals of Paediatric Rheumatology 2012; 1: 31-35.
  23. DeWitt EM, Kimura Y, Beukelman T, Nigrovic PA, Onel K, Prahalad S, Schneider, R, Stoll ML, Angeles-Han S, Milojevic D, Schikler KN, Vehe R, Weiss J, Weiss P, Ilowite N, Wallace C. Consensus treatment plans for new-onset systemic juvenile idiopathic arthritis. Arthritis Care and Research 2012; 64: 1001-1010.
  24. Stoll ML, Good J, Sharpe T, Beukelman T, Young D, Waite PW, Cron RQ. Intraarticular corticosteroid injections to the temporomandibular joints are safe and appear to be effective therapy in children with juvenile idiopathic arthritis. Journal of Oral and Maxillofacial Surgery 2012; 70: 1802-1807.
  25. Stoll ML, Sharpe T, Beukelman T, Good J, Young D, Cron RQ. Risk factors for temporomandibular joint arthritis in children with juvenile idiopathic arthritis. Journal of Rheumatology 2012; 39: 1880-1887.
  26. Nyland JF, Stoll ML, Jiang F, Feng F, Gavalchin J. Mechanisms involved in the p62-73 idiopeptide-modulated delay of lupus nephritis in SNF(1) mice. Lupus 2012; 21:1552-1564.
  27. Stoll ML, Morlandt A, Teerawattanapong S, Young D, Waite PD, Cron RQ. Safety and efficacy of intra-articular infliximab therapy for treatment resistant temporomandibular joint arthritis in children: a retrospective study. Rheumatology 2013; 52: 554-559.
  28. Henderson LA, Loring SL, Gill RR, Liao KP, Ishizawar R, Kim S, Perlmutter-Goldenson R, Rothman D, Son MB, Stoll ML, Zemel LS, Sandborg C, Dellaripa PF, Nigrovic PA. Shrinking lung syndrome as a manifestation of pleuritis: a new model based on pulmonary physiological studies. Journal of Rheumatology 2013; 40: 273-281.
  29. Tambralli A, Beukelman T, Weiser P, Atkinson TP, Cron RQ, Stoll ML. High doses of infliximab in the management of juvenile idiopathic arthritis. Journal of Rheumatology 2013; 40: 1749-1755.
  30. Stoll ML, Cron RQ. Treatment of juvenile idiopathic arthritis in the biologic age. Rheumatic Disease Clinics of North America 2013; 39: 751-766.
  31. Vaid YN, Dunnavant DF, Royal SA, Beukelman T, Stoll ML, Cron RQ. Imaging of the temporomandibular joint in juvenile idiopathic arthritis. Arthritis Care and Research 2014; 66: 47-54.
  32. Stoll ML, Cron RQ. Treatment of juvenile idiopathic arthritis: a revolution in care. Pediatric Rheumatology 2014; 12:13.
  33. Kimura Y, Morgan Dewitt E, Beukelman T, Stoll ML, Nigrovic PA, Onel K, Prahalad S, et al. Adding canakinumab to the childhood arthritis and rheumatology research alliance consensus treatment plans for systemic juvenile idiopathic arthritis. Arthritis Care and Research 2014; 66: 1430-1431.
  34. Stoll ML, Kumar R, Morrow CD, Lefkowitz EJ, Cui X, Genin A, Cron RQ, Elson CO. Altered microbiota associated with abnormal humoral immune responses to commensal organisms in enthesitis-related arthritis. Arthritis Research and Therapy 2014; 16:486.
  35. Tambralli A, Beukelman T, Cron RQ, and Stoll ML. Safety and efficacy of rituximab in childhood-onset lupus and other rheumatic diseases. Journal of Rheumatology 2015;42:541-546.
  36. Ringold S, Hendrickson A, Abramson L, Beukelman T, Blier PR, Bohnsack J, Chalom EC, Gewanter HL, Gottlieb B, Hollister R, Hsu J, Hudgins A, Ilowite NT, Klein-Gitelman M, Lindsley C, Lopez Benitez J, Lovell DJ, Mason T, Milojevic D, Moorthy LN, Nanda K, Onel K, Prahalad S, Rabinovich CE, Ray L, Rouster-Stevens K, Ruth N, Shishov M, Spalding S, Syed R, Stoll M, Vehe RK, Weiss JE, White AJ, Wallace CA, Sobel RE. Novel method to collect medication adverse events in juvenile arthritis: Results from the Childhood Arthritis and Rheumatology Research Alliance Enhanced Drug Safety Surveillance Project. Arthritis Care and Research 2015; 67: 529-537.
  37. Stoll ML, Cron RQ, and Saurenmann RT. Systemic and intra-articular anti-inflammatory therapy of temporomandibular joint arthritis in children with juvenile idiopathic arthritis. Seminars in Orthodontics, 2015; 21:125-133.
  38. Stoll ML. Gut microbes, immunity, and spondyloarthritis. Clinical Immunology, 2015;159:134-142.
  39. Stoll ML, Vaid Y, Gurash S, Beukelman T, Waite PD, Cron RQ. Magnetic resonance imaging findings following intra-articular infliximab therapy for refractory temporomandibular joint arthritis among children with juvenile idiopathic arthritis. Journal of Rheumatology 2015; 42:2155 - 2159.
  40. Stoll ML and Cron RQ. Temporomandibular Joint Arthritis in Juvenile Idiopathic Arthritis: The Last Frontier. International Journal of Clinical Rheumatology 2015; 10:273-286.
  41. Arvonen M, Berntson L, Pokka T, Karttunen TJ, Vähäsalo P, Stoll ML. Gut Microbiota-Host Interactions and Juvenile Idiopathic Arthritis. Pediatric Rheumatology 2016; 14:44.
  42. Mannion M, McAllister L, Cron RQ, Stoll ML. Ustekinumab as a therapeutic option for children with refractory enthesitis-related arthritis. Journal Clinical Rheumatology 2016; 22:282.
  43. Stoll ML, Cron RQ. The microbiota in pediatric rheumatic disease: epiphenomenon or therapeutic target? Current Opinion in Rheumatology 2016; 28:537.
  44. Stoll ML, Kumar R, Lefkowitz EJ, Cron RQ, Morrow CD, Barnes S.  Fecal metabolomics in pediatric spondyloarthritis implicate decreased metabolic diversity and altered tryptophan metabolism as pathogenic factors. Genes and Immunity 2016; 17:400 – 405. PMID 27786174
  45. Spencer CH, Rouster-Stevens K, Gewanter H, Syverson G, Modica R, Schmidt K, Emery H, Wallace C, Grevich S, Nanda K, Zhao YD, Shenoi S, Tarvin S, Hong S, Lindsley C, Weiss JE, Passo M, Ede K, Brown A, Ardalan K, Bernal W, Stoll ML, Lang B, Carrasco R, Agaiar C, Feller L, Bukulmez H, Vehe R, Kim H, Schmeling H, Gerstbacher D, Hoeltzel M, Eberhard B, Sundel R, Kim S, Huber AM, Patwardhan A and Pediatric Rheumatology Collaborators.  Biologic therapies for refractory juvenile dermatomyositis: five years of experience of the Childhood Arthritis and Rheumatology Research Alliance in North America. Pediatric Rheumatology 2017; 15:50. PMID 28610606
  46. Zisman D, Gladman DD, Stoll ML, Stand V, Lavi I, Hsu JJ, Mellins ED. The juvenile psoriatic cohort in the CARRA registry: clinical characteristics, classification, and outcomes. Journal of Rheumatology 2017;44:342-50. PMID 28148698
  47. Stoll ML, Grubbs JA, Beukelman T, Mannion ML, Jester JW, Cron RQ, Crain MJ. Risk of Tuberculosis among pediatric subjects taking tumor necrosis factor inhibitors in Alabama. Pediatric Rheumatology 2017;15:79. PMID 29121953
  48. Hugle B, Spiegel L, Hotte J, Wiens S, Herlin T, Cron RQ, Stoll ML, Vinod S, Stoustrup P, Pedersen TK, Twilt M. Isolated Arthritis of the Temporomandibular Joint as the Initial Manifestation of Juvenile Idiopathic Arthritis. In press, Journal of Rheumatology. PMID 28864647
  49. Paul B, Royston K, Yuanyuan L, Stoll ML, Skibola C,, Barnes S, Morrow CD,  Tollefsbol TO. Impact of genistein on the gut microbiome of humanized mice and its role in breast tumor inhibition. PLOS ONE 2017; 12(12):e0189756. PMID 29267377
  50. Stoll ML, Guleria S, Young DW, Mannion ML, Young DW, Royal SA, Cron RQ, and Vaid YN. Defining the normal appearance of the temporomandibular joints by magnetic resonance imaging with contrast: a prospective study in non-inflamed children. Pediatric Rheumatology 2018;16:18. PMID 29368603
  51. Stoll ML, Weiss PF, Weiss JE, Peter A Nigrovic, Edelheit B, Spencer C, Punaro M,  Schikler K, Reiff A, Kumar R, Cron RQ, Morrow CD, Lefkowitz EF. Age and Fecal Microbial Strain Specific Differences in Patients with Spondyloarthritis. Arthritis Research and Therapy 2018;20:14. PMID 29382366
  52. Vinod SS, Reed AB, Maxwell J, Cron RQ, and Stoll ML. Pediatric Rheumatology Infusion Center:  Report on Therapeutic Protocols and Infusions Given Over 4 Years with Focus on Adverse Events Over 1 Year. Pediatric Rheumatology 2018;16:16. PMID 29523211
  53. Samad A, Stoll ML, Lavi I, Hsu JJ, Strand V, Robinson TN, Mellins ED, Zisman D. Adiposity in children with juvenile psoriatic arthritis. Journal of Rheumatology 2018;45:411. PMID 29247150
  54. Stoll ML, Waite PD, and Cron RQ. TMJ Arthritis in JIA, Now What? Pediatric Rheumatology, 2018;16:32. PMID 29695255
  55. Zisman D, Stoll ML, Aviel YB, Mellins ED. Juvenile Psoriatic Arthritis: A Report from the GRAPPA 2017 Annual Meeting. Journal of Rheumatology Suppl 2018;94:11. PMID 29858347
  56. Stoll ML, Amin D, Poholek CH, Harvey RJ, Young D, Cron RQ, and Waite PD. Risk factors for heterotopic bone of the temporomandibular joint in children with chronic arthritis treated with intraarticular therapy. Journal of Rheumatology 2018; 45:1301. PMID 29764966.
  57. Bevans SL, Theos AJ, Fowler PG, Pavlidakey PG, Stoll M, Sami N. Pediatric ocular lichen planus and lichen planopilaris: One new case and a review of the literature. Pediatric Dermatology 2018; 35:859. PMID 30168195
  58. Crayne CB, Eloseily EM, Mannion ML, Azert SP, Weiser P, Beukelman T, Stoll ML, Feig DI, Atkinson TP, and Cron RQ. Rituximab treatment for chronic steroid-dependent Henoch-Schonlein purpura: 8 cases and a review of the literature. Pediatr. Rheumatol. Online J. 2018; 16:71.
  59. Stoll ML, Pierce MK, Watkins JA, Zhang M, Weiss PF, Weiss JE, Elson CO, Cron RQ, Kumar R, Morrow CD, Schoeb TR. Akkermansia muciniphila is permissive to arthritis in the K/BxN mouse model of arthritis. Genes and Immunity 2019;20:158-166.
  60. Ringold S, Angeles-Han S, Beukelman T, Lovell D, Cuello CA, Becker M, Colbert RA, Feldman B, Ferguson P, Gewanter H, Gray T, Guzman J, Horonjeff J,  Nigrovic P, Ombrello M, Passo M, Stoll ML, Rabinovich E, Schneider R, Halyabar O,  Hays K, Shah AA, Sullivan N, Szymanski AM, Turgunbaev M, Miller AS, Reston J. 2018 ACR/AF Guideline for the Treatment of JIA: Therapeutic Approaches for Non-Systemic Polyarthritis, Sacroiliitis, and Enthesitis. Arthritis and Rheumatol 2019;71:846-863.
  61. Angeles-Han S, Ringold S, Beukelman T, Lovell D, Cuello Garcia CA, Becker M, Colbert R, Feldman B, Holland G,  Ferguson P, Gewanter H, Gray T, Guzman J, Horonjeff J,  Nigrovic P, Ombrello M, Passo M, Stoll ML, Rabinovich E, Sen N, Schneider R, Halyabar O,  Hays K, Shah AA, Sullivan N, Szymanski AM, Turgunbaev M, Miller AS, Reston J. 2018 ACR/AF Guideline for the Screening, Monitoring and Treatment of Juvenile Idiopathic Arthritis-Associated Uveitis. Arthritis and Rheumatol 2019;71:864-877.
  62. Stoustrup P, Resnick CM, Pedersen TK, Abramowicz S, Michelotti A, Kuseler A, Verna C, Kellenberger JC, Nordal EB, Caserta G, Jankovska I, Halbig J, Kristensen KD, Arvidsson LZ, Spiegel L, Stoll ML, Lerman M,  Glerup M, Defabianis P, Frid P,  Alstergren P, Cron RQ, Ringold R, Nørholt SE, Peltomäki T, Herlin T, Peacock Z,   Twilt M. Standardizing Terminology and Assessment for Orofacial Conditions in Juvenile Idiopathic Arthritis: International, Multidisciplinary Consensus-based Recommendations. Journal of Rheumatology 2019;46:518-522.