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Steven N Austad, PhD

Steven Austad, PhD
 
Distinguished Professor/Chair
Department of Biology
CH 464
Phone: (205) 934-8302
Email: austad@uab.edu
Full CV

I am originally from Southern California, but my family moved a lot, so I lived in every part of the United States before heading to college. After gaining an English Literature degree, I had a variety of jobs — newspaper reporter, taxi driver, wild animal trainer.... Training lions for the movie business awakened my interest in biology, so I went back to school, eventually getting my Ph.D. in biology.

My early research was field-based. I have done field research in several parts of the United States, Venezuela, East Africa, Micronesia, and Papua New Guinea. Once I became interested in the biology of aging, my research became more laboratory oriented. Perhaps because of my background in English, I have always been eager to communicate the excitement of science to the public at large. In that capacity I have written popular books, planned museum exhibits, and produced a regular newspaper column on science.

Research Interests

One of the more intriguing problems in biology is why animals age. No law of nature dictates that this should be so. Why can’t nature, which is so successful at producing healthy adults from single fertilized eggs, do the seemingly much simpler task of keeping that adult healthy through time? Moreover, why do some animals like mice age quickly, while others like bats, birds, whales, and people age slowly. It is these question that focus and guide my research.

Aging is not just an abstract and intriguing biological problem. It is the number one cause of death and disability in today’s world, vastly more significant than Alzheimer’s disease, cancer, or heart disease, because aging is the major risk for all of them plus a host of other health problems.

The long-term goal of my research is to develop treatments to slow the aging process, thus keeping people fit and healthy longer. My laboratory works with different animal species, especially those which are more successful at aging than humans. We work on exotic species, like clams that live more than 500 years, and hydra that don’t age at all, in order to discover such treatments. We also develop measures of laboratory animal health, so that we can assess whether a treatment that makes a mouse live longer also improves the quality of its life. Finally, it has been discovered in recent years that the sexes often respond very differently to treatments than extend life and health. Something that dramatically slows aging in one sex may have no effect on the other sex. We have recently begun exploring why this is so.

News

Select Recent Publications

  1. Austad SN. 2018. The comparative biology of mitochondrial function and the rate of aging. Integrative and Comparative Biology. Jun 22. doi: 10.1093/icb/icy068. [Epub ahead of print]
  2. Hoffman JM, O’Neill DG, Creevy KE, Austad SN. 2018. Do female dogs age differently than male dogs? Journals of Gerontology: Biological Science and Medical Sciences 73(2), 150-156. DOI: 10.1093/gerona/glx061. PMC5861885.
  3. Ross CN, Austad S, Brasky K, Brown CJ, Forney LJ, Gelfond JA, Lanford R, Richardson A, Tardif SD. 2017. The development of a specific pathogen free (SPF) barrier colony of marmosets (Callithrix jacchus) for aging research. Aging (Albany, NY) 9(12), 2544-2558. DOI: 10.18632/aging. 101340. PMC5764392.
  4. Austad SN (2017). Sex differences in health and longevity. In Hazzard’s Geriatric Medicine and Gerontology, 7th Edition. J Halter, J Ouslander, S Studenski, K High, S Asthana, C Ritchie, and M Supiano (Eds.) McGraw-Hill: New York. Chapter 8 (pp 133-147). ISBN-13: 978-0-07-183345-5.
  5. Schenkelaars Q, Tomczyk S, Wenger Y, Edundayo K, Girard V, Buzgariu W, Austad S, Galliot B. (2017). Hydra, a model system for deciphering the mechanisms of aging and resistance to aging. Handbook of Models for Human Aging, 2nd Ed., PM Conn (ed.). Academic Press: Cambridge, MA.
  6. Fischer KE, Hoffman JM, Sloane LB, Gelfond JAL, Soto VY, Richardson AG, Austad SN. (2016). A cross-sectional study of male and female C57BL/6Nia mice suggests lifespan and healthspan are not necessarily correlated. Aging. 8(10):2370-2391. doi: 10.18632/aging.101059. PMC5115894.
  7. Huffman DM Justice JN, Stout MB, Kirkland JL, Barzilai N, Austad SN. (2016) Evaluating Health Span in Preclinical Models of Aging and Disease: Guidelines, Challenges, and Opportunities for Geroscience. Journals of Gerontology A: Biological Sciences and Medical Sciences. 71(11),1395-1406. doi:10.1093/gerona/glw106. PMC5055649.



Let's Reimagine the Normal Trajectory of Life
Steven Austad | TEDxBirmingham
Published on Apr 4, 2016