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Shawn Robert Gilbert, M. D.

Department of Surgery
Division of Orthopaedic Surgery
ACC Suite 316
1600 7th Avenue South
Birmingham, AL 35233
Phone: (205) 975-7499
Full CV

My basic science research focuses on translational research to improve healing of bone and growth plate injuries, and investigations on the role of vasculature in skeletal development and regeneration. Clinical research interests include children's fractures, scoliosis, clubfoot, and limb deformity. Research into the impact of childhood obesity on musculoskeletal health spans basic science and clinical research.


  • University of North Carolina School of Medicine
    M.D. with Honors, 1996
  • University of North Carolina at Chapel Hill
    B.S. Biology with distinction and Highest Honors, 1992


  • 2014
  • 2013
  • 2012
  • 2011
  • Pre 2011
  1. 1. Angular Deformities of the Lower Extremity in Children, Gilbert, SR, Woiczik MR, invited submission Orthopaedic Knowledge Online Journal. 2014;12(6): Accessed May 27, 2014.
  2. Altered lower extremity fracture characteristics in obese pediatric trauma patients. Gilbert SR, Maclennan PA, Backstrom I, Creek A, Sawyer J. J Orthop Trauma. 2014 Apr 15. [Epub ahead of print] [PMID: 24740109]
  1. Obesity in Pediatric Orthopaedics. Gilbert SR. Curr Orthop Practice. 2013 Nov/Dec, 24(6):576-80.
  2. SPECT and micro-CT imaging of and extremity leg-injury rat model. McKay J, Zelickson A, George M, Samuel S, Zinn K, Gilbert S. Journal of Nuclear Medicine; 54(2):1204-2013
  3. High-fidelity simulations for orthopaedic residents: medical complications andsystems challenges. Lee White M, Gilbert SR, Youngblood AQ, Zinkan JL, Martin R, Tofil NM. J Bone Joint Surg Am. 2013 May 15;95(10):e701-4. [PMID: 23677371]
  4. Weight Gain During External Fixation, Culotta BA, Gilbert SR, Sawyer JR, Ruch A, Sellers T. Journal of Children's Orthopaedics, J Child Orthop. 2013 Mar;7(2):147-50. [PMID:24432073] [PMCID:PMC3593013]
  1. Pediatric Obesity and Traumatic Lower Extremity Long Bone Fracture Outcomes.  Backstrom I, Rue L, McClendon P, Sawyer J, Gilbert SR.  J Trauma Acute Care Surg. 2012 Oct; 73(4):966-71. [PMID: 22902734]
  2. Discovery of a new molecular probe ML228: An activator of the hypoxia inducible factor (HIF) pathway. Theriault JR, Felts AS, Bates BS, Perez JR, Palmer M, Gilbert SR, Dawson ES, Engers JL, Lindsley CW, Emmitte KA. Bioorg & Med Chem Let 22(1):76-81, 2012. [PMID 22172704]
  3. An Evaluation of Carrier Agents for Desferoxamine, an Up-Regulator of Vascular Endothelial Growth Factor. Hertzberg BP, Graff RD, Gilbert SR, Joshua B. Holt JB, Dahners LE. J Biomaterials Applications 2012 Jan 19. [Epub ahead of print] [PMID 22262572]
  1. Biphasic Peptide Amphiphile Nanomatrix Embedded with Hydroxyapatite Nanoparticles for Stimulated Osteoinductive Response. Anderson JM, Patterson JL, Vines JB, Javed A, Gilbert SR, Jun HW. ACS Nano 2011 Nov 17. [Epub ahead of print]. [PMID: 22077993]
  2. Increasing Vascularity to Improve healing of a Segmental Defect of the Rat Femur. Stewart R, Goldstein J, Eberhardt A, Gabriel Chu GT, Gilbert S. J Orthop Trauma 25(8):472-6, 2011. [PMID: 21738061]
  1. Role of HIF-1alpha in skeletal development. Wan C, Shao J, Gilbert SR, Riddle RC, Long F, Johnson RS, Schipani E, Clemens TL. Ann N Y Acad Sci. 1192(1):322, 2010.  [PMID: 20392254]  [PMCID: 3047468]
  2. Prolyl Hydroxylase Inhibitors Increase Neoangiogenesis and Callus Formation Following Femur Fracture in Mice. Shen X, Wan C, Ramaswamy G, Mavalli M, Wang Y, Duvall CL, Deng LF, Guldberg RE, Eberhart A, Clemens TL, Gilbert SRJ Orth Res. 27:1298, 2009.  [PMID: 19338032]
  3. Hypoxia and HIF-1α Expression in the Epiphyseal Cartilage Following Ischemic Injury to the Immature Femoral Head. Kim HK, Bian H, Aya-ay J, Garces A, Morgan EF, Gilbert SR, Bone 45(2):280, 2009.  [PMID: 19345751]
  4. Role of hypoxia inducible factor-1alpha pathway in bone regeneration. Wan C, Gilbert SR, Wang Y, Cao XM, Shen X, Ramaswamy G, Jacobsen KA, Alaql ZS, Gerstenfeld LC, Einhorn TA, Eberhardt AW, Deng L, Guldberg RE, Clemens TL. J Musculoskelet Neuronal Interact 8:323, 2008.  [PMID: 19147958]
  5. Bone Formation during Distraction Osteogenesis is Dependent on Both VEGFR1 and VEGFR2 Signaling.  Jacobsen KA, SW, Zainab SA, Wan C, Fitch JL, Mason ZD, Cole RM, Gilbert SR, Clemens TL, Morgan EF, Einhorn TA, Gerstenfeld LC.  J Bone Min Res.  23(5):596, 2008.  [PMID: 18433297]  [PMC2674537]
  6. Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration. *Gilbert SR, *Wan C, Wang Y, Cao X, Shen X, Ramaswamy G, Jacobsen KA, Alaql ZS, Eberhardt AW, Gerstenfeld LC, Einhorn TA, Deng L, Clemens TL.    Proc Natl Acad Sci 105(2):686, 2008. (*co-first authors)  [PMID: 18184809] [PMC2206597]
  7. Oxygen sensing and osteogenesis. Wang Y, Wan C, Gilbert SR, and Clemens TL.  Ann NY Acad Sci. 1117:1, 2007.  [PMID: 18056033
  8. Presentation of Distal Humerus Physeal Separations.  Gilbert SR, Conklin, MJ. Ped Emerg Care, 23(11):816, 2007.  [PMID: 18007213]
  9. The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. Wang Y, Wan C, Deng L, Liu X, Gilbert SR, Bouxsein ML, Faugere MC, Guldberg RE, Gerstenfeld LC, Haase VH, Johnson RS, Schipani E, Clemens TL.  J Clin Invest. 117:1616, 2007[PMID: 17549257] [PMC: 1878533]
  10. Neuropathic arthropathy of the elbow in a pediatric patient with myelomeningocele. Zimmermann A, Law C, Blount J, Gilbert S. Dev Neurorehabil. 2007 Jul-Sep;10(3):261-4. [PMID: 17564866]
  11. Altered Skeletal Maturation in Moderate to Severe Cerebral Palsy. Henderson RC, Gilbert SR, et al. Dev Med Child Neur 47:229, 2005.  [PMID: 15832545]
  12. Skeletal maturation in children with quadriplegic cerebral palsy.  Gilbert SR, Gilbert AC, Henderson RC. J Pediatr Orthop 24:292, 2004.  [PMID: 15105725]
  13. Primary synovial osteochondromatosis of the hip: report of two cases with long-term follow-up after synovectomy and a review of the literature. Gilbert SR, Lachiewicz PF. Am J Orthopedics 26(8):555, 1997.  [PMID: 9267556]